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Merck
CN

D6196

Dimebon dihydrochloride hydrate

≥98% (HPLC)

别名:

2,8-Dimethyl-5-[2-(6-methyl-3-pyridinyl)ethyl]-2,3,4,5-tetrahydro-1H-pyrido[4,3-b]indole dihydrochloride hydrate, Dimebolin dihydrochloride hydrate, Dimeboline dihydrochloride hydrate, Dimebone dihydrochloride hydrate

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关于此项目

经验公式（希尔记法）:
C21H25N3 · 2HCl · xH2O
化学文摘社编号:
97657-92-6
分子量:
392.37 (anhydrous basis)
NACRES:
NA.77
PubChem Substance ID:
329798824
UNSPSC Code:
12352200
MDL number:
MFCD17215933

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产品名称

Dimebon dihydrochloride hydrate, ≥98% (HPLC)

InChI key

QQHQMWVYYVVAOV-UHFFFAOYSA-N

SMILES string

O.Cl.Cl.CN1CCc2c(C1)c3cc(C)ccc3n2CCc4ccc(C)nc4

InChI

1S/C21H25N3.2ClH.H2O/c1-15-4-7-20-18(12-15)19-14-23(3)10-9-21(19)24(20)11-8-17-6-5-16(2)22-13-17;;;/h4-7,12-13H,8-11,14H2,1-3H3;2*1H;1H2

assay

≥98% (HPLC)

form

powder

color

white to off-white

solubility

H2O: ≥10 mg/mL

storage temp.

2-8°C

Quality Level

100

Biochem/physiol Actions

Mechanism of neuroprotection and cognition enhancement is not certain, but Dimebon blocks both cholinesterase and the NMDA receptor simultaneously and also appears to block the action of neurotoxic β-amyloid proteins and inhibit L-type calcium channels, and may exert a neuroprotective effect by blocking a novel target that involves mitochondrial pores.

Features and Benefits

This compound is featured on the Calcium Channels page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

pictograms

Exclamation mark
GHS07

signalword

Warning

Hazard Classifications

Acute Tox. 4 Oral - Eye Irrit. 2 - Skin Irrit. 2

存储类别

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

法规信息

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历史批次信息供参考:

分析证书(COA)

Lot/Batch Number
050M4626V
0000098325
0000098326
0000062747
0000062748

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Diana Duarte et al.
Biomolecules, 12(2) (2022-02-26)
Despite the progressive research and recent advances in drug therapy to treat solid tumours, the number of cases and deaths in patients with cancer is still a major health problem. Drug repurposing coupled to drug combination strategies has been gaining

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