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About This Item
经验公式（希尔记法）:
C15H21NO6
CAS号:
分子量:
311.33
Beilstein:
46376
MDL编号:
UNSPSC代码:
12352202
PubChem化学物质编号:
NACRES:
NA.77
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方案
≥90% (HPLC)
表单
powder
储存温度
−20°C
SMILES字符串
OC([C@H](C)/C=C/C=C([C@@H]1[C@H](CC(O)=O)[C@@H](C(O)=O)NC1)/C)=O
InChI
1S/C15H21NO6/c1-8(4-3-5-9(2)14(19)20)11-7-16-13(15(21)22)10(11)6-12(17)18/h3-5,9-11,13,16H,6-7H2,1-2H3,(H,17,18)(H,19,20)(H,21,22)/b5-3+,8-4-/t9-,10+,11-,13+/m1/s1
InChI key
VZFRNCSOCOPNDB-AOKDLOFSSA-N
基因信息
human ... GRIK1(2897)
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一般描述
软骨藻酸是由各种海洋藻类合成的杂环氨基酸神经毒素，结构与红藻氨酸类似。
应用
软骨藻酸已用于：
- 作为兴奋性神经毒素研究大脑转录响应
- 研究其对于海洋贝类紫贻贝的细胞毒性、基因毒性和免疫毒性作用
- 研究其对小鼠胎儿的神经行为影响
生化/生理作用
强效谷氨酸受体和红藻氨酸受体激动剂。
软骨藻酸可用作驱虫药。它可结合和激活中枢神经系统的红藻氨酸型谷氨酸受体。
软骨藻酸是兴奋性氨基酸谷氨酸和红藻氨酸受体的强效激动剂，对AMPA/红藻氨酸受体的亲和性是所有红藻氨酸激动剂中最高的。它可引起神经元过度兴奋，导致储能耗竭。
特点和优势
该化合物是受体分类及信号转导手册上谷氨酸受体（离子通道家族）页面上的特色化合物。想要浏览手册的其他页面， 请单击此处。
这种化合物是神经科学研究的特色产品。点击此处发现更多特色神经科学产品。在sigma.com/discover-bsm可了解更多关于生物活性小分子的其他研究领域。
警示用语：
Danger
危险声明
危险分类
Acute Tox. 4 Oral - STOT SE 1
靶器官
Central nervous system
储存分类代码
6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
WGK
WGK 3
个人防护装备
dust mask type N95 (US), Eyeshields, Gloves
Seafood Neurotoxins I: Shellfish Poisoning and the Nervous System
Clinical Neurotoxicology, 441-447 (2009)
Neurobehavioral assessment of mice following repeated oral exposures to domoic acid during prenatal development
Shiotani M, et al.
Neurotoxicology and Teratology, 64, 8-19 (2017)
Yu He et al.
Journal of agricultural and food chemistry, 58(22), 11525-11533 (2010-10-23)
Domoic acid (DA), a neurotoxic amino acid produced by some strains of phytoplankton, is responsible for the human toxic syndrome amnesic shellfish poisoning. This exocitotoxin results in neuronal degeneration and necrosis in specific regions of the hippocampus. Because DA accumulates
M Andjelkovic et al.
Environment international, 49, 115-119 (2012-09-27)
A main known culprit causing amnesic shellfish poisoning in humans is domoic acid (DA). The toxin appearance in sea waters (by counting the toxin producing algae) and consequently in shellfish is closely monitored to prevent acute intoxications with gastrointestinal symptoms
Terry F McGrath et al.
Biosensors & bioelectronics, 41, 96-102 (2012-09-04)
A prototype fluorescent based biosensor has been developed for the antibody based detection of food related contaminants. Its performance was characterised and showed a typical antibody binding signal of 200-2000 mV, a short term noise of 9.1 mV, and baseline
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DISCOVER Bioactive Small Molecules for Neuroscience
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