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![2-脱氧-2-[（7-硝基-2,1,3-苯并恶二唑-4-基）氨基]-D-葡萄糖 ≥97% (HPLC)](/deepweb/assets/sigmaaldrich/product/structures/104/527/40bd5a41-ebc4-484e-a10e-891fecfaea79/640/40bd5a41-ebc4-484e-a10e-891fecfaea79.png)
方案
≥90% (TLC)
作用机制
DNA synthesis | interferes
储存温度
−20°C
SMILES字符串
Cl.Cn1cc(NC=O)cc1C(=O)Nc2cc(C(=O)Nc3cc(C(=O)NCCC(N)=N)n(C)c3)n(C)c2
生化/生理作用
Reported to specifically inhibit the initiation of RNA synthesis.
Terri G Edwards et al.
Antiviral research, 91(2), 177-186 (2011-06-15)
Human papillomavirus (HPV) causes cervical cancer and other hyperproliferative diseases. There currently are no approved antiviral drugs for HPV that directly decrease viral DNA load and that have low toxicity. We report the potent anti-HPV activity of two N-methylpyrrole-imidazole polyamides
Gaetano Marverti et al.
Amino acids, 42(2-3), 641-653 (2011-08-05)
Acquired resistance to cisplatin (cDDP) is a multifactorial process that represents one of the main problems in ovarian cancer therapy. Distamycin A is a minor groove DNA binder whose toxicity has limited its use and prompted the synthesis of derivatives
Vivian Chagas da Silveira et al.
Journal of inorganic biochemistry, 105(12), 1692-1703 (2011-11-22)
Previous studies on copper(II) complexes with oxindole-Schiff base ligands have shown their potential antitumor activity towards different cells, inducing apoptosis through a preferential attack to DNA and/or mitochondria. Herein, we better characterize the interactions between some of these copper(II) complexes
Mariko Asagi et al.
Biophysical chemistry, 149(1-2), 34-39 (2010-04-17)
Distamycin A (Dst) is an antibiotic which binds to the minor groove of double-stranded DNA at A/T-rich regions. We have examined the affinity and mode of Dst binding to DNA duplexes containing a conserved A/T core and variable terminal A/T
Austin E Smith et al.
Biochemistry, 50(38), 8107-8116 (2011-08-23)
The molecular mechanism for the displacement of HMGA1 proteins from DNA is integral to disrupting their cellular function, which is linked to many metastatic cancers. Chemical shift and NOESY NMR experiments provide structural evidence for the displacement of an AT
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