D6135
Distamycin A hydrochloride from Streptomyces distallicus
≥90% (TLC)
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关于此项目
经验公式（希尔记法）:
C22H27N9O4 · HCl
化学文摘社编号:
分子量:
517.97
UNSPSC Code:
12352200
PubChem Substance ID:
EC Number:
229-505-6
MDL number:
SMILES string
Cl.Cn1cc(NC=O)cc1C(=O)Nc2cc(C(=O)Nc3cc(C(=O)NCCC(N)=N)n(C)c3)n(C)c2
assay
≥90% (TLC)
mode of action
DNA synthesis | interferes
storage temp.
−20°C
Biochem/physiol Actions
Reported to specifically inhibit the initiation of RNA synthesis.
Studies on the effect of distamycin A on the DNA dependent RNA polymerase system.
B Puschendorf et al.
Biochemical and biophysical research communications, 43(3), 617-624 (1971-05-07)
Marisol Vieites et al.
Journal of inorganic biochemistry, 105(12), 1704-1711 (2011-12-07)
In the search for drugs with anti-trypanosome activity, we had previously synthesized two series of platinum and palladium analogous compounds of the formula [M(II)Cl(2)(HL)], where HL were bioactive 5-nitrofuryl or 5-nitroacroleine thiosemicarbazone derivatives. In this work, we thoroughly characterized [M(II)Cl(2)(HL)]
Shozeb M Haider et al.
Biochimie, 93(8), 1239-1251 (2011-06-04)
This focused review article discusses in detail, all available high-resolution small molecule ligand/G-quadruplex structural data derived from crystallographic and NMR based techniques, in an attempt to understand key factors in ligand binding and to highlight the biological importance of these
Danuta Drozdowska et al.
Molecules (Basel, Switzerland), 16(4), 3066-3076 (2011-04-13)
A novel and straightforward solid phase synthesis of distamycin analogues containing benzene units has been developed.
Parijat Majumder et al.
PloS one, 8(2), e57693-e57693 (2013-03-06)
The condensed structure of chromatin limits access of cellular machinery towards template DNA. This in turn represses essential processes like transcription, replication, repair and recombination. The repression is alleviated by a variety of energy dependent processes, collectively known as "chromatin
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