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Merck
CN

D6000

2′-脱氧腺苷 5′-二磷酸 钠盐

≥95% (HPLC), synthetic (organic), powder

别名:

dADP

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关于此项目

经验公式(希尔记法):
C10H15N5O9P2 · xNa+
化学文摘社编号:
分子量:
411.20 (free acid basis)
NACRES:
NA.51
PubChem Substance ID:
UNSPSC Code:
41106305
EC Number:
276-280-5
MDL number:
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产品名称

2′-脱氧腺苷 5′-二磷酸 钠盐,

InChI key

KZGAPWRJMWSNQO-UHFFFAOYSA-N

InChI

1S/C10H15N5O9P2.Na.H/c11-9-8-10(13-3-12-9)15(4-14-8)7-1-5(16)6(23-7)2-22-26(20,21)24-25(17,18)19;;/h3-7,16H,1-2H2,(H,20,21)(H2,11,12,13)(H2,17,18,19);;

SMILES string

[Na].Nc1ncnc2n(cnc12)C3CC(O)C(COP(O)(=O)OP(O)(O)=O)O3

biological source

synthetic (organic)

assay

≥95% (HPLC)

form

powder

storage temp.

−20°C

Quality Level

Application

2′-脱氧腺苷5′-二磷酸(dADP)可用于与诸如来自大肠埃希菌的多核苷酸磷酸化酶的酶合成脱氧腺苷酸寡核苷酸。dADP用作细菌聚(A)聚合酶的抑制剂。 脱氧ADP可以用作研究ATPase以及DNA和RNA聚合酶特异性的替代底物或抑制剂。

General description

2′-脱氧腺苷5′-二­磷­酸(dADP)是一种含有腺嘌呤作为核碱基的嘌呤。已知它体内嘌呤降解过程中次黄嘌呤氧化酶作用于次黄嘌呤的产物。

pictograms

Skull and crossbones

signalword

Danger

Hazard Classifications

Acute Tox. 3 Dermal - Acute Tox. 3 Inhalation - Acute Tox. 3 Oral - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

target_organs

Respiratory system

存储类别

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

wgk

WGK 3

ppe

Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges


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M P Deutscher
The Journal of biological chemistry, 253(16), 5579-5584 (1978-08-25)
Poly(A) synthesis and degradation have been examined in Escherichia coli cells made permeable to nucleotides by treatment with toluene. Although newly synthesized poly(A) is normally rapidly degraded in this system, extraction of the soluble portion of the cell effectively eliminates
Kevin N Kirouac et al.
Journal of molecular biology, 407(3), 382-390 (2011-02-08)
The ability of DNA polymerases to differentiate between ribonucleotides and deoxribonucleotides is fundamental to the accurate replication and maintenance of an organism's genome. The active sites of Y-family DNA polymerases are highly solvent accessible, yet these enzymes still maintain a
S Gillam et al.
Nucleic acids research, 2(5), 613-624 (1975-05-05)
Polynucleotide phosphorylase from Escherichia coli can be used to catalyse the addition of short tracts of deoxyadenylate residues to the 3'-termini of deoxyribooligonucleotides of the type pdAn-dN (where dN = dC, dT or dG) using dADP as donor. Similarly, the
Mahmoud Kandeel et al.
Journal of bioenergetics and biomembranes, 42(5), 361-369 (2010-08-17)
Nucleoside diphosphate kinases (NDKs) play a key role in maintaining the intracellular energy resources as well as the balance of nucleotide pools. Recently, attention has been directed to NDKs owing to its role in activating various chemotherapeutic agents. The binding

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