生物来源
synthetic (organic)
质量水平
检测方案
≥97%
形式
powder
溶解性
ethanol: 5 mg/mL
储存温度
room temp
SMILES字符串
Oc1ccc2C=CC(=O)Oc2c1O
InChI
1S/C9H6O4/c10-6-3-1-5-2-4-7(11)13-9(5)8(6)12/h1-4,10,12H
InChI key
ATEFPOUAMCWAQS-UHFFFAOYSA-N
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生化/生理作用
7,8-Dihydroxycoumarinan is an inhibitor of protein kinases. It is an active lactone present in plants such as Daphne Korean Nakai, and Thymelaeaceae Daphne. It serves as as analgesic, antiviral and antibacterial agent. 7,8-Dihydroxycoumarinan is found to induce tumor apoptosis via a number of signalling pathways. Thus, it is believed to exhibit antitumor effects. 7,8-Dihydroxycoumarinan might also be useful in treating lung carcinoma. It is also known to be used in treating coagulation disorders and rheumatoid arthritis. 7,8-Dihydroxycoumarinan is known to induce neurite growth and lengthen neuronal survival. It helps in clearing substances inducing necrosis, maintains water-electrolytes balance and energy metabolism. 7,8-Dihydroxycoumarinan is involved in the generation of neurotrophic factor and helps in restoring neuron function.
WGK
WGK 2
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
Eyeshields, Gloves, type N95 (US)
E B Yang et al.
Biochemical and biophysical research communications, 260(3), 682-685 (1999-07-15)
Protein kinases play key roles in the control of cell proliferation, differentiation and metabolism. In this work, we studied the effect of coumarin and its derivatives, including daphnetin, esculin, 2-OH-coumarin, 4-OH-coumarin and 7-OH-coumarin, on the activity of protein kinases. It
7, 8-Dihydroxycoumarin inhibits A549 human lung adenocarcinoma cell proliferation by inducing apoptosis via suppression of AktNF-kappaB signaling
Wang Y, et al.
Experimental and Therapeutic Medicine, 5(6), 1770-1774 (2013)
Neurotrophic effects of 7,8-dihydroxycoumarin in primary cultured rat
cortical neurons
Yan L, et al.
Experimental and Therapeutic Medicine, 28(5), 493?498-493?498 (2012)
Si-Cheng Liang et al.
Drug metabolism and disposition: the biological fate of chemicals, 38(6), 973-980 (2010-02-24)
Daphnetin has been developed as an oral medicine for treatment of coagulation disorders and rheumatoid arthritis in China, but its in vitro metabolism remains unknown. In the present study, the UDP-glucuronosyltransferase (UGT) conjugation pathways of daphnetin were characterized. Two metabolites
Rongfeng Yao et al.
European journal of pharmacology, 670(1), 286-294 (2011-09-15)
Daphnetin extracted from Daphne odora Var. marginata contains coumarin compounds, which possess properties of analgesic and anti-inflammatory effects. In this study, we investigated the therapeutic effect of daphnetin on anti-arthritis and its role on the balance of Tregs and Th17
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