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About This Item
经验公式（希尔记法）:
C15H10O4 · xH2O
CAS号:
分子量:
254.24 (anhydrous basis)
EC 号:
MDL编号:
UNSPSC代码:
12352200
PubChem化学物质编号:
NACRES:
NA.77
应用
7,8-二羟基黄酮水合物已被用作小鼠中原肌球蛋白受体激酶（TrkB）激动剂，并用于抑制TrkB以监控诱发性兴奋性突触后电流 (eEPSC) 。
生化/生理作用
7,8-二羟基黄酮是一种选择性酪氨酸激酶受体B（TrkB）受体激动剂。它表现出了脑源性神经营养因子（BDNF）的所有治疗效果，如保护神经元免于凋亡、抑制红藻氨酸诱导的毒性、减少中风中的梗塞体积以及在帕金森病动物模型中的神经保护—没有BDNF限制了其治疗潜力的较差药代动力学特征。
7,8-二羟基黄酮（7,8-DHF），可用于帮助识别和区分由TrkB激活介导的生理效应和细胞信号传导通路，例如那些涉及的神经保护、记忆、血管舒张和高血压。7,8-二羟基黄酮会引发对东莨菪碱所致阿尔茨海默样病变的保护作用。
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
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Brain-derived neurotrophic factor (BDNF) signaling plays a major role in the regulation of hippocampal neurogenesis in the adult brain. While the majority of studies suggest that this is due to its effect on the survival and differentiation of newborn neurons
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