所有图片(1)
About This Item
经验公式（希尔记法）:
C12H10O4
CAS号:
分子量:
218.21
MDL编号:
UNSPSC代码:
12352200
PubChem化学物质编号:
NACRES:
NA.77
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质量水平
方案
≥99%
表单
solid
储存温度
−20°C
SMILES字符串
COC1=C(OC)C(=O)c2ccccc2C1=O
InChI
1S/C12H10O4/c1-15-11-9(13)7-5-3-4-6-8(7)10(14)12(11)16-2/h3-6H,1-2H3
InChI key
ZEGDFCCYTFPECB-UHFFFAOYSA-N
应用
2,3-二甲氧基-1,4-萘醌已被用于研究乙醇对低氧和高氧条件下足细胞凋亡的影响。
用于研究ROS在细胞毒性、细胞凋亡和坏死中的作用。
生化/生理作用
2,3-二甲氧基-1,4-萘醌（DMNQ）具有通过氧化还原循环产生H2O2的能力，但无法与谷胱甘肽（GSH）结合。
警示用语：
Warning
危险声明
危险分类
Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
靶器官
Respiratory system
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
dust mask type N95 (US), Eyeshields, Gloves
历史批次信息供参考:
分析证书(COA)
Lot/Batch Number
Extracellular glutathione and gamma-glutamyl transpeptidase prevent H2O2-induced injury by 2, 3-dimethoxy-1, 4-naphthoquinone
Shi M, et al.
Free radical biology & medicine, 15(1), 57-67 (1993)
J M Dypbukt et al.
The Journal of biological chemistry, 269(48), 30553-30560 (1994-12-02)
Increasing concentrations (1-100 microM) of the redox cycling quinone, 2,3-dimethoxy-1,4-naphthoquinone (DMNQ), stimulated growth, triggered apoptosis, or caused necrosis of pancreatic RINm5F cells, depending on the dose and duration of the exposure. Following the exposure of RINm5F cells to 10 microM
Yasuhiro Ishihara et al.
Toxicology and applied pharmacology, 214(2), 109-117 (2006-01-25)
Two mechanisms have been proposed to explain quinone cytotoxicity: oxidative stress via the redox cycle and the arylation of intracellular nucleophiles. As the redox cycle is catalyzed by NADPH cytochrome P450 reductase, cytochrome P450 systems are expected to be related
Anda R Gliga et al.
Scientific reports, 7(1), 9284-9284 (2017-08-26)
Cerium oxide nanoparticles (nanoceria) display antioxidant properties and have shown cytoprotective effects both in vitro and in vivo. Here, we explored the effects of nanoceria on neural progenitor cells using the C17.2 murine cell line as a model. First, we
Koji Kawata et al.
Environmental science & technology, 41(10), 3769-3774 (2007-06-06)
Microarray technology is proving to be a useful tool to classify undefined environmental toxicants, to investigate underlying mechanisms of toxicity, and to identify candidate toxicant-specific genetic markers by examining global effects of putative toxicants on gene expression profiles. The aim
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