生物来源
synthetic (organic)
质量水平
检测方案
≥98%
形式
powder
杂质
inosine, essentially free
溶解性
1 M NH4OH: 50 mg/mL, clear, colorless
储存温度
−20°C
SMILES字符串
OC[C@H]1O[C@H](C[C@@H]1O)n2cnc3C(=O)NC=Nc23
InChI
1S/C10H12N4O4/c15-2-6-5(16)1-7(18-6)14-4-13-8-9(14)11-3-12-10(8)17/h3-7,15-16H,1-2H2,(H,11,12,17)/t5-,6+,7+/m0/s1
InChI key
VGONTNSXDCQUGY-RRKCRQDMSA-N
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应用
2′-脱氧肌苷已被用于通过液相色谱串联质谱（LC-MS/MS）对单个DNA样品中的核苷形式DNA损伤进行定量。它也被用作高效液相色谱分析的标准品。
生化/生理作用
2′-脱氧肌苷是一种由次黄嘌呤通过β-N9-糖苷键与2′-脱氧核糖连接而组成的核苷。DNA中的2′-脱氧肌苷可来自于腺苷的脱氨作用。2′-脱氧肌苷可作为模型化合物用于研究可能影响DNA结构的加合物形成和自由基化学。2′-脱氧肌苷可用于产生具有自我回避能力的杂交敏感型荧光DNA探针。
2′-脱氧肌苷是次黄嘌呤的一种核苷形式。它是由活性氮引起的DNA损害的一种DNA损伤产物。2′-脱氧肌苷是通过N2O3由亚硝化脱氨而形成的。
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
Eyeshields, Gloves, type N95 (US)
Quantification of DNA damage products resulting from deamination, oxidation and reaction with products of lipid peroxidation by liquid chromatography isotope dilution tandem mass spectrometry
Taghizadeh K, et al.
Nature Protocols, 3(8), 1287-1287 (2008)
Lipid peroxidation dominates the chemistry of DNA adduct formation in a mouse model of inflammation.
Bo Pang et al.
Carcinogenesis, 28(8), 1807-1813 (2007-03-10)
In an effort to define the prevalent DNA damage chemistry-associated chronic inflammation, we have quantified 12 DNA damage products in tissues from the SJL mouse model of nitric oxide (NO) overproduction. Using liquid chromatography-mass spectrometry/MS and immunoblot techniques, we analyzed
Shuji Ikeda et al.
Organic & biomolecular chemistry, 8(3), 546-551 (2010-01-22)
Hybridization-sensitive fluorescent probes have an inherent disadvantage: self-dimerization of the probe prevents the fluorescence quenching prior to hybridization with the target, resulting in a high background signal. To avoid self-dimerization of probes, we focused on a base pair formed by
Chia-Chia Lee et al.
DNA repair, 9(10), 1073-1079 (2010-08-11)
Deoxyinosine (dI) in DNA can arise from hydrolytic or nitrosative deamination of deoxyadenosine. It is excised in a repair pathway that is initiated by endonuclease V, the nfi gene product, in Escherichia coli. Repair was studied in vitro using M13mp18
Nobuyuki Horinouchi et al.
Applied microbiology and biotechnology, 71(5), 615-621 (2005-11-12)
2'-Deoxyribonucleosides are important as building blocks for the synthesis of antisense drugs, antiviral nucleosides, and 2'-deoxyribonucleotides for polymerase chain reaction. The microbial production of 2'-deoxyribonucleosides from simple materials, glucose, acetaldehyde, and a nucleobase, through the reverse reactions of 2'-deoxyribonucleoside degradation
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