D5035
1,1-二甲双胍 盐酸盐
≥97%
别名:
盐酸二甲双胍
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线性分子式:
NH2C(=NH)NHC(=NH)N(CH3)2 · HCl
化学文摘社编号:
分子量:
165.62
UNSPSC Code:
12352100
PubChem Substance ID:
EC Number:
214-230-6
MDL number:
产品名称
1,1-二甲双胍 盐酸盐, ≥97%
InChI key
OETHQSJEHLVLGH-UHFFFAOYSA-N
InChI
1S/C4H11N5.ClH/c1-9(2)4(7)8-3(5)6;/h1-2H3,(H5,5,6,7,8);1H
SMILES string
Cl[H].CN(C)C(=N)NC(N)=N
assay
≥97%
mp
223-226 °C (lit.)
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Biochem/physiol Actions
二甲双胍是一种降糖药，可以降低血糖水平，提高胰岛素敏感性。 它的代谢作用，包括抑制肝脏糖异生，至少部分是通过激活LKB1-AMPK（AMP活化蛋白激酶）通路介导的。 这一通路的激活也参与了二甲双胍在癌细胞系中的抗增殖和促凋亡作用。
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Mhairi C Towler et al.
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A Isakovic et al.
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Mahvash Zakikhani et al.
Cancer research, 66(21), 10269-10273 (2006-10-26)
Recent population studies provide clues that the use of metformin may be associated with reduced incidence and improved prognosis of certain cancers. This drug is widely used in the treatment of type 2 diabetes, where it is often referred to
Reuben J Shaw et al.
Science (New York, N.Y.), 310(5754), 1642-1646 (2005-11-26)
The Peutz-Jegher syndrome tumor-suppressor gene encodes a protein-threonine kinase, LKB1, which phosphorylates and activates AMPK [adenosine monophosphate (AMP)-activated protein kinase]. The deletion of LKB1 in the liver of adult mice resulted in a nearly complete loss of AMPK activity. Loss
Nicolas Musi et al.
Diabetes, 51(7), 2074-2081 (2002-06-28)
Metformin is an effective hypoglycemic drug that lowers blood glucose concentrations by decreasing hepatic glucose production and increasing glucose disposal in skeletal muscle; however, the molecular site of metformin action is not well understood. AMP-activated protein kinase (AMPK) activity increases
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