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D4297

Sigma-Aldrich

脱氧胆酸

BioXtra, ≥98% (HPLC)

别名:

3α,12α-二羟基-5β-胆甾烯酸, 7-脱氧胆酸, 脱氧胆酸

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About This Item

经验公式（希尔记法）:
C24H40O4
CAS号:
83-44-3
分子量:
392.57
Beilstein:
3219882
EC 号:
201-478-5
MDL编号:
MFCD00003673
UNSPSC代码:
12161900
PubChem化学物质编号:
24893857

生物来源

bovine bile (ex gall bladder)

描述

anionic

产品线

BioXtra

方案

≥98% (HPLC)

表单

powder

分子量

micellar avg mol wt 1200-5000

聚集数

3-12

杂质

≤0.005% Phosphorus (P)
≤0.1% Insoluble matter

灼烧残渣

≤0.1%

CMC

2-6

mp

171-174 °C (lit.)

痕量阳离子

Al: ≤0.001%
Ca: ≤0.01%
Cu: ≤0.0005%
Fe: ≤0.005%
K: ≤0.005%
Mg: ≤0.005%
NH4+: ≤0.05%
Na: ≤0.02%
Pb: ≤0.001%
Zn: ≤0.0005%

HLB

16

官能团

carboxylic acid

运输

ambient

储存温度

room temp

SMILES字符串

C[C@H](CCC(O)=O)[C@H]1CC[C@H]2[C@@H]3CC[C@@H]4C[C@H](O)CC[C@]4(C)[C@H]3C[C@H](O)[C@]12C

InChI

1S/C24H40O4/c1-14(4-9-22(27)28)18-7-8-19-17-6-5-15-12-16(25)10-11-23(15,2)20(17)13-21(26)24(18,19)3/h14-21,25-26H,4-13H2,1-3H3,(H,27,28)/t14-,15-,16-,17+,18-,19+,20+,21+,23+,24-/m1/s1

InChI key

KXGVEGMKQFWNSR-LLQZFEROSA-N

基因信息

human ... ATIC(471)

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一般描述

脱氧胆酸是可能影响细胞内信号转导和基因表达的一种胆汁酸。

应用

脱氧胆酸已被用于一项研究中，以评估熊去氧胆酸（UDCA）与脱氧胆酸（DCA）的生理浓度如何影响小鼠肠道组织的屏障功能。 它也已被用于一项研究中，以表征肝脏破坏细胞色素p450（CYP）氧化还原酶基因小鼠模型中的胆汁形成。

相关产品

产品编号
说明
价格

象形图

Exclamation mark
GHS07

警示用语：

Warning

危险分类

Acute Tox. 4 Oral - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

靶器官

Respiratory system

储存分类代码

11 - Combustible Solids

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

个人防护装备

dust mask type N95 (US), Eyeshields, Gloves

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number
062K16631V
062K16631
SLBK3902V
038K0144
127K01231

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Ying Kong et al.
The international journal of biochemistry & cell biology, 44(12), 2321-2332 (2012-08-21)
There is evidence indicating that bile acid is a promoter of colorectal cancer. Deoxycholic acid modifies apoptosis and proliferation by affecting intracellular signaling and gene expression. We are interested in revealing the relationship between deregulated miRNAs and deoxycholic acid in
Cindy Kunne et al.
Hepatology (Baltimore, Md.), 57(4), 1509-1517 (2012-11-28)
The difference in bile salt (BS) composition between rodents and humans is mainly caused by formation of muricholate in rodents as well as by efficient rehydroxylation of deoxycholic acid. The aim of this study was to characterize bile formation in
J Stadler et al.
Cancer letters, 38(3), 315-320 (1988-01-01)
Rectal biopsies and fecal collections were obtained from a consecutive series of 34 outpatients prior to colonoscopy at a gastroenterology clinic. Subsequently, 14 were found to have no colonic pathology, 13 had adenomatous polyps, (3 of those had a previous
Kunihiko Nishino et al.
Antimicrobial agents and chemotherapy, 54(5), 2239-2243 (2010-03-10)
NlpE, an outer membrane lipoprotein, functions during envelope stress responses in Gram-negative bacteria. In this study, we report that overproduction of NlpE increases multidrug and copper resistance through activation of the genes encoding the AcrD and MdtABC multidrug efflux pumps
Lotta K Stenman et al.
American journal of physiology. Gastrointestinal and liver physiology, 304(3), G227-G234 (2012-12-04)
Impairment of gut barrier is associated with a fat-rich diet, but mechanisms are unknown. We have earlier shown that dietary fat modifies fecal bile acids in mice, decreasing the proportion of ursodeoxycholic acid (UDCA) vs. deoxycholic acid (DCA). To clarify
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