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D4071

5, 15-DPP

Name: 5, 15-DPP
Brand: SIGMA
Price: 5896.35 CNY
Availability: InStock

别名:

5,15-二苯基-21H,23H-卟吩, 5,15-二苯基卟, 5,15-二苯基卟啉

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1 EA

¥5,896.35

国内现货，预计发货时间2025年4月14日详情

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1 EA

¥5,896.35

About This Item

经验公式（希尔记法）:

C₃₂H₂₂N₄

CAS号:

22112-89-6

分子量:

462.54

MDL编号:

MFCD08276335

UNSPSC代码:

12352200

PubChem化学物质编号:

329798793

NACRES:

NA.77

¥5,896.35

国内现货，预计发货时间2025年4月14日详情

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此商品	54849	57934	57935
58298 SUPELCOSIL^™ LC-18 HPLC Column	54849 SUPELCOSIL^™ LC-18 HPLC Column	57934 SUPELCOSIL^™ LC-18 HPLC Column	57935 SUPELCOSIL^™ LC-18 HPLC Column
separation technique reversed phase	separation technique reversed phase	separation technique reversed phase	separation technique reversed phase
matrix silica gel, spherical particle platform	matrix silica gel, spherical particle platform	matrix silica gel, spherical particle platform	matrix silica gel, spherical particle platform
particle size 5 μm	particle size 5 μm	particle size 5 μm	particle size 5 μm
technique(s) HPLC: suitable	technique(s) HPLC: suitable	technique(s) HPLC: suitable	technique(s) HPLC: suitable
agency suitable for USP L1	agency suitable for USP L1	agency suitable for USP L1	agency suitable for USP L1

应用

5, 15-DPP已被用作信号传感器和转录激活因子3 (STAT3)抑制剂：

分析其对恶性周围神经鞘瘤(MPNST)存活和增殖的影响[1]
研究其对胸腺基质淋巴生成素(TSLP)调节人滋养层细胞转移基因23-H1（NME1或nm23-H1）表达的影响[2]
研究其对17β-雌二醇和2,3,7,8-四氯二苯并-对二恶英(TCDD)诱导的人巨噬细胞和子宫内膜间质细胞M2极化的影响[3]

生化/生理作用

5,15-DPP是一种选择性STAT3抑制剂以及一种选择性STAT3-SH2拮抗剂

储存分类代码

11 - Combustible Solids

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

历史批次信息供参考:

分析证书(COA)

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Combined 17β-Estradiol with TCDD Promotes M2 Polarization of Macrophages in the Endometriotic Milieu with Aid of the Interaction between Endometrial Stromal Cells and Macrophages.

Yun Wang et al.

PloS one, 10(5), e0125559-e0125559 (2015-05-08)

The goal of this study is to elucidate the effects of 17β-estradiol and TCDD (2,3,7,8-tetrachlorodibenzo-p-dioxin) on macrophage phenotypes in the endometriotic milieu. Co-culture of endometrial stromal cells (ESCs) and U937 cells (macrophage cell line) was performed to simulate the endometriotic

Thymic stromal lymphopoietin downregulates NME1 expression and promotes invasion in human trophoblasts via the activation of STAT3 signaling pathway.

Ying Wang et al.

Clinical immunology (Orlando, Fla.), 143(1), 88-95 (2012-03-01)

Our previous study has demonstrated that TSLP induces the invasion of human trophoblasts and plays a role in embryo implantation. The present study is undertaken to explore the mechanism by which TSLP modulates trophoblast invasion. It was revealed that TSLP

ErbB4 promotes malignant peripheral nerve sheath tumor pathogenesis via Ras-independent mechanisms.

Jody Fromm Longo et al.

Cell communication and signaling : CCS, 17(1), 74-74 (2019-07-12)

We have found that erbB receptor tyrosine kinases drive Ras hyperactivation and growth in NF1-null malignant peripheral nerve sheath tumors (MPNSTs). However, MPNSTs variably express multiple erbB receptors with distinct functional characteristics and it is not clear which of these

Inhibiting the activation of MAPK (ERK1/2) in stressed Müller cells prevents photoreceptor degeneration.

Shaoxue Zeng et al.

Theranostics, 12(15), 6705-6722 (2022-10-04)

Rationale: Müller cells play an essential role in maintaining the health of retinal photoreceptors. Dysfunction of stressed Müller cells often results in photoreceptor degeneration. However, how these cells communicate under stress and the signalling pathways involved remain unclear. In this

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WGK

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