所有图片(1)
About This Item
经验公式（希尔记法）:
C32H22N4
CAS号:
分子量:
462.54
MDL编号:
UNSPSC代码:
12352200
PubChem化学物质编号:
NACRES:
NA.77
形式
powder
质量水平
SMILES字符串
c1ccc(cc1)-c2c3ccc(cc4ccc([nH]4)c(-c5ccccc5)c6ccc(cc7ccc2[nH]7)n6)n3
InChI
1S/C32H22N4/c1-3-7-21(8-4-1)31-27-15-11-23(33-27)19-25-13-17-29(35-25)32(22-9-5-2-6-10-22)30-18-14-26(36-30)20-24-12-16-28(31)34-24/h1-20,33,36H/b23-19-,24-20-,25-19-,26-20-,31-27-,31-28-,32-29-,32-30-
InChI key
FNNOEKVUXXVPAI-DUVOQLPESA-N
应用
5, 15-DPP已被用作信号传感器和转录激活因子3 (STAT3)抑制剂：
- 分析其对恶性周围神经鞘瘤(MPNST)存活和增殖的影响
- 研究其对胸腺基质淋巴生成素(TSLP)调节人滋养层细胞转移基因23-H1（NME1或nm23-H1）表达的影响
- 研究其对17β-雌二醇和2,3,7,8-四氯二苯并-对二恶英(TCDD)诱导的人巨噬细胞和子宫内膜间质细胞M2极化的影响
生化/生理作用
5,15-DPP是一种选择性STAT3抑制剂以及一种选择性STAT3-SH2拮抗剂
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
Ying Wang et al.
Clinical immunology (Orlando, Fla.), 143(1), 88-95 (2012-03-01)
Our previous study has demonstrated that TSLP induces the invasion of human trophoblasts and plays a role in embryo implantation. The present study is undertaken to explore the mechanism by which TSLP modulates trophoblast invasion. It was revealed that TSLP
Yun Wang et al.
PloS one, 10(5), e0125559-e0125559 (2015-05-08)
The goal of this study is to elucidate the effects of 17β-estradiol and TCDD (2,3,7,8-tetrachlorodibenzo-p-dioxin) on macrophage phenotypes in the endometriotic milieu. Co-culture of endometrial stromal cells (ESCs) and U937 cells (macrophage cell line) was performed to simulate the endometriotic
Jody Fromm Longo et al.
Cell communication and signaling : CCS, 17(1), 74-74 (2019-07-12)
We have found that erbB receptor tyrosine kinases drive Ras hyperactivation and growth in NF1-null malignant peripheral nerve sheath tumors (MPNSTs). However, MPNSTs variably express multiple erbB receptors with distinct functional characteristics and it is not clear which of these
Shaoxue Zeng et al.
Theranostics, 12(15), 6705-6722 (2022-10-04)
Rationale: Müller cells play an essential role in maintaining the health of retinal photoreceptors. Dysfunction of stressed Müller cells often results in photoreceptor degeneration. However, how these cells communicate under stress and the signalling pathways involved remain unclear. In this
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