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一般描述
二肽基肽酶IV(DPP IV)属于脯氨酰特异性蛋白酶家族成员。它是一种二聚体II型整合膜糖蛋白，广泛表达于上皮和非上皮组织中。主要表达于肾脏和结肠。
应用
二肽基肽酶IV抑制剂已用于体内急性研究，评估小鼠中血浆胰高血糖素样肽(GLP-1)对特定分泌剂的快速反应。
生化/生理作用
二肽基肽酶IV(DPP IV)是胰高血糖素样肽(GLP-1)、胰岛素刺激激素和葡萄糖依赖性胰岛素释放肽(GIP)的调节剂。它是治疗2型糖尿病(T2DM)的重要靶点。DPP-4抑制剂可延长GLP-1和GIP活性，对于维持血糖稳态十分重要。与早前口服降糖药物相比，这类抑制剂对血糖控制的增强作用持续时间更久。DPP-4也可作为结合蛋白，及胞外因子配体。
序列
Ile-Pro-Ile
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
Francisco Alejandro Lagunas-Rangel et al.
Biomedicines, 11(11) (2023-11-25)
Dipeptidyl peptidase 4 (DPP4) inhibitors, commonly known as gliptins, have been an integral part of the treatment of type 2 diabetes mellitus (T2DM) for several years. Despite their remarkable efficacy in lowering glucose levels and their compatibility with other hypoglycemic
Sebastiano Bruno Solerte et al.
Acta diabetologica, 57(7), 779-783 (2020-06-09)
SARS-CoV-2 causes severe respiratory syndrome (COVID-19) with high mortality due to a direct cytotoxic viral effect and a severe systemic inflammation. We are herein discussing a possible novel therapeutic tool for COVID-19. Virus binds to the cell surface receptor ACE2;
Rajesh Gupta et al.
Current drug targets, 10(1), 71-87 (2009-01-20)
Dipeptidyl peptidase IV (DPP IV) is a key regulator of insulin-stimulating hormones, glucagon-like peptide (GLP-1) and glucose-dependent insulinotropic polypeptide (GIP), thus it is a promising target for the treatment of Type 2 Diabetes mellitus (T2DM). Inhibition of plasma DPP IV
Brandon L Panaro et al.
Molecular metabolism, 37, 100990-100990 (2020-04-13)
Glucagon-like peptide-1 is a nutrient-sensitive hormone secreted from enteroendocrine L cells within the small and large bowel. Although GLP-1 levels rise rapidly in response to food ingestion, the greatest density of L cells is localized to the distal small bowel
Sourav De et al.
Mini reviews in medicinal chemistry, 19(2), 88-97 (2018-04-26)
Diabetes mellitus is an emerging predator and affecting around 422 million adults worldwide. Higher levels of circulating insulin and increased pressure on the pancreas to produce insulin have been inferred as possible etiology for diabetes leading to a higher risk
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