InChI key
KBAUFVUYFNWQFM-UHFFFAOYSA-N
InChI
1S/C17H22N2O.C4H6O4/c1-17(20-14-13-19(2)3,15-9-5-4-6-10-15)16-11-7-8-12-18-16;5-3(6)1-2-4(7)8/h4-12H,13-14H2,1-3H3;1-2H2,(H,5,6)(H,7,8)
SMILES string
OC(=O)CCC(O)=O.CN(C)CCOC(C)(c1ccccc1)c2ccccn2
form
powder
originator
Sanofi Aventis
Quality Level
Gene Information
human ... HRH1(3269)
General description
多西拉敏属于乙醇胺类抗组胺药，经肝脏代谢为 N -去甲基多西拉敏和 N , N -二去甲基多西拉敏。 它通常是一种非处方药 (OTC)，用于治疗过敏和感冒症状。
Application
琥珀酸多西拉敏盐已被用作检查发育毒性的治疗药物。
琥珀酸多西拉敏已被用于研究在CS培养基低视黄酸浓度的情况下，非致畸性暴露（non-teratogenic exposures ）对人胚胎干细胞聚集体（HESCA）-CSR的形态和基因表达的影响。
Biochem/physiol Actions
H 1 组胺受体拮抗剂；催眠药。
多西拉敏抑制组胺 H1 受体。它与失眠的短期管理和普通感冒症状的暂时缓解有关。另一方面，多西拉敏中毒与横纹肌溶解和继发性急性肾功能衰竭有关。
对小鼠的研究显示，多西拉敏诱导肝微粒体细胞色素 P450 和其它与甲状腺素 (T4) 代谢有关的酶。本药与盐酸吡哆醇合用，可治疗晨吐。
多西拉敏抑制组胺 H1 受体。它与失眠的短期管理和普通感冒症状的暂时缓解有关。另一方面，多西拉敏中毒与横纹肌溶解和继发性急性肾功能衰竭有关。
对小鼠的研究显示，多西拉敏诱导肝微粒体细胞色素 P450 和其它与甲状腺素 (T4) 代谢有关的酶。本药与盐酸吡哆醇合用，可治疗晨吐。
signalword
Warning
hcodes
Hazard Classifications
Acute Tox. 4 Dermal - Acute Tox. 4 Inhalation - Acute Tox. 4 Oral - STOT SE 3
target_organs
Respiratory system
存储类别
11 - Combustible Solids
wgk
WGK 2
ppe
dust mask type N95 (US), Eyeshields, Faceshields, Gloves
L J Brandes et al.
Journal of the National Cancer Institute, 86(10), 770-775 (1994-05-18)
Present studies of drug-induced tumor growth promotion have evolved from earlier investigations into the mechanism of action of N,N-diethyl-2-[4-(phenylmethyl)phenoxy[ethanamine.HCl, a tamoxifen derivative which potently inhibits lymphocyte mitogenesis in vitro and stimulates tumor growth in vivo. It is thought that potency
D V Gauvin et al.
European journal of pharmacology, 294(1), 281-288 (1995-12-27)
Rats were trained to discriminate between 10 mg/kg cocaine and saline injections under a fixed ratio 10 schedule of food-motivated lever press responding. Once stimulus control was achieved, reinforced test sessions were conducted to assess the degree of generalization of
Husnain Syed et al.
BMJ case reports, 2009, doi:10-doi:10 (2009-01-01)
The present report highlights the possible adverse effects of doxylamine, a common over the counter sleep aid. Doxylamine is an antihistamine that at toxic doses can cause anticholinergic effects, including seizures, rhabdomyolysis and death. The following case describes a patient
J O Lay et al.
Biomedical & environmental mass spectrometry, 13(11), 627-632 (1986-11-01)
Three glucuronide metabolites of doxylamine succinate were collected in a single fraction using high-performance liquid chromatography (HPLC) from the urine of dosed male Fischer 344 rats. The metabolites were then separated using an additional HPLC step into fractions containing predominantly
L F Soto et al.
Postgraduate medicine, 93(8), 227-229 (1993-06-01)
Clinicians should be aware of the complications of rhabdomyolysis in patients who ingest doxylamine succinate and other over-the-counter antihistamines. The easy availability of these substances increases the potential not only for intentional overdose by adults but also for inadvertent ingestion
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