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表单
powder
质量水平
创始人
Sanofi Aventis
SMILES字符串
OC(=O)CCC(O)=O.CN(C)CCOC(C)(c1ccccc1)c2ccccn2
InChI
1S/C17H22N2O.C4H6O4/c1-17(20-14-13-19(2)3,15-9-5-4-6-10-15)16-11-7-8-12-18-16;5-3(6)1-2-4(7)8/h4-12H,13-14H2,1-3H3;1-2H2,(H,5,6)(H,7,8)
InChI key
KBAUFVUYFNWQFM-UHFFFAOYSA-N
基因信息
human ... HRH1(3269)
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一般描述
多西拉敏属于乙醇胺类抗组胺药，经肝脏代谢为 N -去甲基多西拉敏和 N , N -二去甲基多西拉敏。 它通常是一种非处方药 (OTC)，用于治疗过敏和感冒症状。
应用
琥珀酸多西拉敏已被用于研究在CS培养基低视黄酸浓度的情况下，非致畸性暴露（non-teratogenic exposures ）对人胚胎干细胞聚集体（HESCA）-CSR的形态和基因表达的影响。
琥珀酸多西拉敏盐已被用作检查发育毒性的治疗药物。
生化/生理作用
H 1 组胺受体拮抗剂；催眠药。
多西拉敏抑制组胺 H1 受体。它与失眠的短期管理和普通感冒症状的暂时缓解有关。另一方面，多西拉敏中毒与横纹肌溶解和继发性急性肾功能衰竭有关。
对小鼠的研究显示，多西拉敏诱导肝微粒体细胞色素 P450 和其它与甲状腺素 (T4) 代谢有关的酶。本药与盐酸吡哆醇合用，可治疗晨吐。
多西拉敏抑制组胺 H1 受体。它与失眠的短期管理和普通感冒症状的暂时缓解有关。另一方面，多西拉敏中毒与横纹肌溶解和继发性急性肾功能衰竭有关。
对小鼠的研究显示，多西拉敏诱导肝微粒体细胞色素 P450 和其它与甲状腺素 (T4) 代谢有关的酶。本药与盐酸吡哆醇合用，可治疗晨吐。
警示用语：
Warning
危险分类
Acute Tox. 4 Dermal - Acute Tox. 4 Inhalation - Acute Tox. 4 Oral - STOT SE 3
靶器官
Respiratory system
储存分类代码
11 - Combustible Solids
WGK
WGK 2
个人防护装备
dust mask type N95 (US), Eyeshields, Faceshields, Gloves
L J Brandes et al.
Journal of the National Cancer Institute, 86(10), 770-775 (1994-05-18)
Present studies of drug-induced tumor growth promotion have evolved from earlier investigations into the mechanism of action of N,N-diethyl-2-[4-(phenylmethyl)phenoxy[ethanamine.HCl, a tamoxifen derivative which potently inhibits lymphocyte mitogenesis in vitro and stimulates tumor growth in vivo. It is thought that potency
Development and validation of method for simultaneous estimation of pyridoxine hydrochloride and doxylamine succinate in tablet dosage form by first order derivative spectroscopy.
Nataraj KS
International Journal of Pharmacy and Pharmaceutical Sciences, 5 (2013)
D V Gauvin et al.
European journal of pharmacology, 294(1), 281-288 (1995-12-27)
Rats were trained to discriminate between 10 mg/kg cocaine and saline injections under a fixed ratio 10 schedule of food-motivated lever press responding. Once stimulus control was achieved, reinforced test sessions were conducted to assess the degree of generalization of
Husnain Syed et al.
BMJ case reports, 2009, doi:10-doi:10 (2009-01-01)
The present report highlights the possible adverse effects of doxylamine, a common over the counter sleep aid. Doxylamine is an antihistamine that at toxic doses can cause anticholinergic effects, including seizures, rhabdomyolysis and death. The following case describes a patient
Sebastián Videla et al.
Drugs in R&D, 12(4), 217-225 (2012-12-13)
Doxylamine succinate, an ethanolamine-based antihistamine, is used in the short-term management of insomnia because of its sedative effects. The data available on the pharmacokinetic profile of doxylamine in humans are limited, notwithstanding that this drug has been marketed in European
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