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Merck
CN

D3768

Sigma-Aldrich

氯化异喹铵 水合物

≥95% (titration)

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别名:
1,1′-癸二双(4-氨基喹啉)二氯化物 水合物
经验公式(希尔记法):
C30H40Cl2N4 · xH2O
分子量:
527.57 (anhydrous basis)
EC 号:
MDL编号:
UNSPSC代码:
12352200
PubChem化学物质编号:

检测方案

≥95% (titration)

形式

powder

mp

≥300 °C (lit.)

SMILES字符串

O.[Cl-].[Cl-].Cc1cc(N)c2ccccc2[n+]1CCCCCCCCCC[n+]3c(C)cc(N)c4ccccc34

InChI

1S/C30H38N4.2ClH.H2O/c1-23-21-27(31)25-15-9-11-17-29(25)33(23)19-13-7-5-3-4-6-8-14-20-34-24(2)22-28(32)26-16-10-12-18-30(26)34;;;/h9-12,15-18,21-22,31-32H,3-8,13-14,19-20H2,1-2H3;2*1H;1H2

InChI key

CZCJAGQJOXJBST-UHFFFAOYSA-N

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生化/生理作用

氯异喹铵是蜂毒明肽-敏感型K+通道的一种选择性阻断剂和XIAP(凋亡蛋白的X连锁抑制剂)抑制剂。它已被证明可通过线粒体功能紊乱、氧化应激以及Raf/MEK/ERK和PI3K/Akt信号通路的下调来诱导人急性早幼粒细胞白血病NB4细胞的细胞毒性。

象形图

Exclamation mark

警示用语:

Warning

危险声明

危险分类

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

靶器官

Respiratory system

WGK

WGK 3

个人防护装备

dust mask type N95 (US), Eyeshields, Gloves


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