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质量水平
检测方案
≥98% (HPLC)
形式
powder
颜色
white to off-white
溶解性
H2O: >30 mg/mL
运输
wet ice
储存温度
−20°C
SMILES字符串
COC(=O)CNC(=O)C(=O)OC
InChI
1S/C6H9NO5/c1-11-4(8)3-7-5(9)6(10)12-2/h3H2,1-2H3,(H,7,9)
InChI key
BNJOZDZCRHCODO-UHFFFAOYSA-N
应用
DMOG用于：
- 缺氧诱导因子（HIF）活性测定
- 研究其对HIF-1α降解和肾脏再生的影响
- 脂肪组织DMOG预处理
- CD34+细胞原代液体培养的媒介对照
- 刺激内皮细胞
二甲基草酰甘氨酸（DMOG）用作TET3蛋白抑制剂。
生化/生理作用
DMGO是一种细胞渗透脯氨酸-4-羟化酶抑制剂，上调HIF（缺氧诱导因子）。HIF蛋白质水平-1α 后转录亚基被脯氨酰和天冬酰胺羟化酶调节（PAH）。PAH活性抑制增强了内源性HIF-1α水平。DMGO是一种细胞透过性、含蛋白脯氨酰羟化酶结构域的竞争性抑制剂（PHDs和HIF-PHs）。已经发现DMOG通过葡萄糖代谢保存对于NFG缺乏细胞培养有神经元保护效果。DMOG在兔子缺血再灌注模型中也可以减轻心肌损伤。DMOG比以前的抑制剂4-苯基-吡啶-2,5-二羧酸更有效（R395889；Sigma-Aldrich稀有化学文库）。IC50 is 5.18 μM.
特点和优势
该化合物是基因调控研究的特色产品。点击此处以了解更多的基因调控特色产品。可访问sigma.com/discover-bsm了解更多关于用于其他研究领域生物活性小分子。
警示用语：
Warning
危险声明
危险分类
Acute Tox. 4 Oral
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
Metabolic reprogramming by HIF-1 activation enhances survivability of human adipose-derived stem cells in ischaemic microenvironments
Chen C, et al.
Cell Proliferation, 50(5), e12363-e12363 (2017)
L Gómez-Maldonado et al.
Oncogene, 34(20), 2609-2620 (2014-07-16)
The presence of hypoxic regions in solid tumors is an adverse prognostic factor for patient outcome. Here, we show that hypoxia induces the expression of Ephrin-A3 through a novel hypoxia-inducible factor (HIF)-mediated mechanism. In response to hypoxia, the coding EFNA3
Jianping Peng et al.
PloS one, 12(5), e0178147-e0178147 (2017-05-26)
Acute kidney injury (AKI) leads to a worse prognosis in diabetic patients compared with prognoses in non-diabetic patients, but whether and how diabetes affects kidney repair after AKI remains unknown. Here, we used scratch-wound healing and transwell migration models to
Yaling Yu et al.
Biomaterials, 165, 48-55 (2018-03-05)
Although mammalian kidney regeneration has been reported to occur throughout life, mature kidneys in mammals are not thought to regenerate sufficiently, particularly glomeruli. In our previous work, we found that renal regeneration could be enhanced by decellularized renal scaffolds after
Targeting the aryl hydrocarbon receptor nuclear translocator complex with DMOG and Stemregenin 1 improves primitive hematopoietic stem cell expansion
Jackson CS, et al.
Stem Cell Research, 21, 124-131 (2017)
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