D3669
3,3′-二硫代二丙酸二(N-羟基丁二酰亚胺酯)
powder
别名:
DTSP, Lomant’s试剂, 二(N-琥珀酰亚胺基)-3,3′-二硫代二丙酸酯, 二硫代双(琥珀酰亚胺丙酸酯）
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关于此项目
经验公式（希尔记法）:
C14H16N2O8S2
化学文摘社编号:
分子量:
404.42
UNSPSC Code:
12352106
NACRES:
NC.07
PubChem Substance ID:
EC Number:
260-931-5
Beilstein/REAXYS Number:
1518074
MDL number:
产品名称
3,3′-二硫代二丙酸二(N-羟基丁二酰亚胺酯), powder
InChI key
FXYPGCIGRDZWNR-UHFFFAOYSA-N
InChI
1S/C14H16N2O8S2/c17-9-1-2-10(18)15(9)23-13(21)5-7-25-26-8-6-14(22)24-16-11(19)3-4-12(16)20/h1-8H2
SMILES string
O=C(CCSSCCC(=O)ON1C(=O)CCC1=O)ON2C(=O)CCC2=O
form
powder
reaction suitability
reagent type: cross-linking reagent
solubility
chloroform: 50 mg/mL
DMF: soluble
acetone: soluble
storage temp.
−20°C
Quality Level
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Application
3,3'-二硫代二丙酸二（N-羟基琥珀酰亚胺酯）（DSP）已被用作蛋白质交联剂。
Disclaimer
在偶联反应过程中避免使用还原剂。
Features and Benefits
通过温和还原，可使二硫键裂解。
General description
3,3'-二硫代二丙酸二（N-羟基琥珀酰亚胺酯）（DSP）是一种含有可裂解二硫键的同双功能交联剂。它通常在pH 7.5（6.5-8.5）的缓冲液中与含有伯胺的分子通过酰胺键发生偶联。
signalword
Warning
hcodes
Hazard Classifications
Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
target_organs
Respiratory system
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
dust mask type N95 (US), Eyeshields, Gloves
Protein phosphatases 2C regulate the activation of the Snf1-related kinase OST1 by abscisic acid in Arabidopsis.
Vlad F
Plant Cell, 21, 3170-3170 (2009)
M Darder et al.
Analytical chemistry, 71(24), 5530-5537 (2000-01-07)
Exposure of gold surfaces to solutions of dithiobis N-succinimidyl propionate (DTSP) gives rise to the modification of the surface with N-succinimidyl-3-thiopropionate (NSTP) which can, in turn, react with amino groups allowing for the covalent immobilization of enzymes such as horseradish
Sunil K Arya et al.
Biosensors & bioelectronics, 25(10), 2296-2301 (2010-04-13)
Gold microelectrode arrays functionalized with dithiobis(succinimidyl propionate) self-assembled monolayer (SAM) have been used to fabricate an ultrasensitive, disposable, electrochemical cortisol immunosensor. Cortisol specific monoclonal antibody (C-Mab) was covalently immobilized on the surface of gold microelectrode array and the sensors were
Michael Neu et al.
Biomacromolecules, 7(12), 3428-3438 (2006-12-13)
Stabilized PEI/DNA polyplexes were generated by cross-linking PEI with biodegradable disulfide bonds. The reaction conversion of different PEIs with the amine reactive cross-linker dithiobis(succinimidyl propionate) (DSP) was investigated, and the molecular weight of the reaction products was identified. Light scattering
N S Green et al.
Protein science : a publication of the Protein Society, 10(7), 1293-1304 (2001-06-23)
Homobifunctional chemical cross-linking reagents are important tools for functional and structural characterization of proteins. Accurate measures of the lengths of these molecules currently are not available, despite their widespread use. Stochastic dynamics calculations now provide quantitative measures of the lengths
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