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![毛喉素，7-脱乙酰基-7-[O-（N-甲基哌嗪基）-γ-丁酰基]-二盐酸盐 Chemically-modified forskolin with greater stability and water solubility than the parent compound.](/deepweb/assets/sigmaaldrich/product/images/426/701/6836ea5a-750e-4c4d-8e6e-ecf6aed4c506/640/6836ea5a-750e-4c4d-8e6e-ecf6aed4c506.jpg)
质量水平
检测方案
≥97%
形式
solid
旋光性
[α]26/D +93.6°, c = 6.12 in chloroform(lit.)
颜色
white to off-white
溶解性
methanol: 28 mg/mL(lit.)
DMSO: 3 mg/mL(lit.)
chloroform: 50 mg/mL
ethanol: 6.6 mg/mL(lit.)
dilute aqueous acid and base: insoluble(lit.)
储存温度
−20°C
SMILES字符串
[H][C@@]12[C@H](O)[C@H](OC(C)=O)[C@@]3(C)O[C@](C)(CC(=O)C3[C@@]1(C)CCCC2(C)C)C=C
InChI
1S/C22H34O5/c1-8-20(5)12-14(24)16-21(6)11-9-10-19(3,4)17(21)15(25)18(26-13(2)23)22(16,7)27-20/h8,15-18,25H,1,9-12H2,2-7H3/t15-,16?,17-,18-,20-,21+,22-/m0/s1
InChI key
ZKZMDXUDDJYAIB-OJPJTMFRSA-N
应用
Useful as a negative control for forskolin.
生化/生理作用
Biologically inactive forskolin analog. Does not stimulate adenylyl cyclase.
特点和优势
This compound is a featured product for Cyclic Nucleotide research. Click here to discover more featured Cyclic Nucleotide products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.
This compound is featured on the Adenylyl cyclases page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
Eyeshields, Gloves, type N95 (US)
法规信息
新产品
V Brès et al.
British journal of pharmacology, 130(8), 1976-1982 (2000-08-22)
To characterize the volume-sensitive, osmolyte permeable anion channels responsible for the osmodependent release of taurine from supraoptic nucleus (SON) astrocytes, we investigated the pharmacological properties of the [(3)H]-taurine efflux from acutely isolated SON. Taurine release induced by hypotonic stimulus (250
F Espinosa et al.
Developmental genetics, 25(2), 103-114 (1999-08-10)
The direct electrophysiological characterization of sperm Ca(2+) channels has been precluded by their small size and flat shape. An alternative to study these channels is to use spermatogenic cells, the progenitors of sperm, which are larger and easier to patch-clamp.
M Morales-Mulia et al.
Biochimica et biophysica acta, 1496(2-3), 252-260 (2000-04-20)
The role of the phospholemman (PLM) on the efflux of taurine and chloride induced by swelling was studied in HEK293 cells overexpressing stable transfected PLM. PLM, a substrate for protein kinases C and A, is a protein that induces an
E X Albuquerque et al.
FEBS letters, 199(1), 113-120 (1986-04-07)
Forskolin, an activator of adenylate cyclase, and its analogs were studied on the nicotinic acetylcholine receptor-ion channel complex (AChR) of rat and frog skeletal muscles. At nanomolar concentrations, forskolin caused desensitization of the AChR located at the junctional region of
Jatinder Ahluwalia
Biochemical and biophysical research communications, 375(4), 596-601 (2008-08-30)
Effective functioning of neutrophils relies upon electron translocation through the NADPH oxidase (NOX). The electron current generated (I(e)) by the neutrophil NADPH oxidase is electrogenic and rapidly depolarises the membrane potential in activated human neutrophils. Swelling activated chloride channels have
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Cyclic nucleotides like cAMP modulate cell function via PKA activation and ion channels.
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