D3385
3′-去磷酸辅酶 A
≥90% (HPLC)
别名:
3′-脱磷酸辅酶 A, dpCoA
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关于此项目
经验公式（希尔记法）:
C21H35N7O13P2S
化学文摘社编号:
分子量:
687.55
NACRES:
NA.51
PubChem Substance ID:
UNSPSC Code:
41106305
MDL number:
Form:
powder
Assay:
≥90% (HPLC)
Solubility:
H2O: soluble-50 mg/mL, clear to slightly hazy, colorless to faintly yellow
Biological source:
synthetic (organic)
InChI key
KDTSHFARGAKYJN-UHFFFAOYSA-N
SMILES string
CC(C)(COP(O)(=O)OP(O)(=O)OCC1OC(C(O)C1O)n2cnc3c(N)ncnc23)C(O)C(=O)NCCC(=O)NCCS
InChI
1S/C21H35N7O13P2S/c1-21(2,16(32)19(33)24-4-3-12(29)23-5-6-44)8-39-43(36,37)41-42(34,35)38-7-11-14(30)15(31)20(40-11)28-10-27-13-17(22)25-9-26-18(13)28/h9-11,14-16,20,30-32,44H,3-8H2,1-2H3,(H,23,29)(H,24,33)(H,34,35)(H,36,37)(H2,22,25,26)
biological source
synthetic (organic)
assay
≥90% (HPLC)
form
powder
impurities
≤1% CoA
solubility
H2O: soluble-50 mg/mL, clear to slightly hazy, colorless to faintly yellow
storage temp.
−20°C
Quality Level
Application
3′-脱磷酸辅酶 A 已被用作启动转录的底物。
脱磷酸辅酶 A 是辅酶 A 的直接前体。通过双功能 CoA 合成酶（CoASy,4′-磷酸泛素腺苷基转移酶/去磷酸-CoA 激酶），其负责 γ-干扰素的转移-ATP 的磷酸盐转化为去磷酸辅酶 A。
Biochem/physiol Actions
3′-脱磷酸辅酶 A (DepCoA) , 也称为脱磷酸辅酶 A (dpCoA) , 是由 4-磷酸泛酰乙胺通过磷酸泛酰乙胺腺苷基转移酶合成。是辅酶 A 生物合成途径中的一种中间体。在去磷酸 CoA 激酶 (CoaE) 存在下，去磷酸辅酶 A 转化为辅酶 A。3′-脱磷酸辅酶与嘌呤类一样共享腺苷二磷酸亚结构，是一种非经典核苷酸，是转录起始的启动因子。在 体外 转录研究中常规用于启动 RNA 合成。
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
Efficient one-pot enzymatic synthesis of dephospho coenzyme A
Sapkota K and Huang F
Bioorganic Chemistry, 76, 23-27 (2018)
RNA capping by transcription initiation with non-canonical initiating nucleotides (NCINs): determination of relative efficiencies of transcription initiation with NCINs and NTPs
Bird JG, et al.
Bio-protocol, 7(12) (2017)
Ishac Nazi et al.
Analytical biochemistry, 324(1), 100-105 (2003-12-05)
A rapid and stoichiometric method for the synthesis of analogues of coenzyme A is described. The method links the enzymes pantothenate kinase, phosphopantotheine adenylyltransferase, and dephosphocoenzyme A kinase in vitro to generate a variety of CoA analogues from chemically synthesized
Thomas J Wubben et al.
Journal of molecular biology, 404(2), 202-219 (2010-09-21)
Phosphopantetheine adenylyltransferase (PPAT) catalyzes the penultimate step in the coenzyme A (CoA) biosynthetic pathway, reversibly transferring an adenylyl group from ATP to 4'-phosphopantetheine (PhP) to form dephosphocoenzyme A. This reaction sits at the branch point between the de novo pathway
S Hoenke et al.
Biochemistry, 39(43), 13223-13232 (2000-10-29)
Malonate decarboxylase from Klebsiella pneumoniae consists of four subunits MdcA, D, E, and C and catalyzes the cleavage of malonate to acetate and CO(2). The smallest subunit MdcC is an acyl carrier protein to which acetyl and malonyl thioester residues
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