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主要文件

安全信息

D3196

Sigma-Aldrich

二肽基肽酶VIII 人

recombinant, expressed in Sf9 cells

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About This Item

UNSPSC代码:
12352204
NACRES:
NA.54

质量水平

200

重组

expressed in Sf9 cells

表单

solution

比活

≥20 units/μg protein

分子量

100 kDa

浓度

≥0.08 mg/mL

运输

dry ice

储存温度

−70°C

相关类别

应用

人二肽基肽酶VIII已用于将ERGIC-53鉴定为α1-抗胰蛋白酶的细胞内转运受体的研究中。人二肽基肽酶VIII也已用于研究ERGIC-53/MCFD2转运受体复合物的货物选择性。

生化/生理作用

二肽基肽酶VIII（DPP8）是在细胞质中表达的100 kDa单体蛋白。它是一种后脯氨酸二肽基氨肽酶，与DPPIV和成纤维细胞活化蛋白（FAP）同源。它水解Ala-Pro、Arg-Pro和Gly-Pro。DPP8具有最佳的中性pH值。它可能参与T细胞活化和免疫功能，因为它与DPPIV相似。它在免疫激活过程中被上调。

物理属性

带有N端GST标签的全长序列

单位定义

一个单位为在pH 7.4，25℃下，每分钟水解1.0皮摩尔的Ala-Pro-AMC。

外形

以溶于40 mM Tris-HCL, pH 8.0, 110 mM NaCl, 2.2 mM KCl, 3 mM DTT 和 20%甘油的溶液形式提供。

储存分类代码

10 - Combustible liquids

WGK

WGK 1

法规信息

常规特殊物品

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number
SLCQ0880
SLCP2736
SLCJ0269
SLBP3118V
SLBN6181V

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  1. Which document(s) contains shelf-life or expiration date information for a given product?

    If available for a given product, the recommended re-test date or the expiration date can be found on the Certificate of Analysis.

  2. How do I get lot-specific information or a Certificate of Analysis?

    The lot specific COA document can be found by entering the lot number above under the "Documents" section.

  3. How do I find price and availability?

    There are several ways to find pricing and availability for our products. Once you log onto our website, you will find the price and availability displayed on the product detail page. You can contact any of our Customer Sales and Service offices to receive a quote.  USA customers:  1-800-325-3010 or view local office numbers.

  4. What is the Department of Transportation shipping information for this product?

    Transportation information can be found in Section 14 of the product's (M)SDS.To access the shipping information for this material, use the link on the product detail page for the product. 

  5. What is the molecular weight of Product D3196, Dipeptidyl Peptidase VIII human?

    The molecular weight of Product D3196, Dipeptidyl Peptidase VIII human with N-terminal GST tag, is 129.3 kDa.

  6. My question is not addressed here, how can I contact Technical Service for assistance?

    Ask a Scientist here.

Beat Nyfeler et al.
The Journal of cell biology, 180(4), 705-712 (2008-02-20)
Secretory proteins are exported from the endoplasmic reticulum (ER) by bulk flow and/or receptor-mediated transport. Our understanding of this process is limited because of the low number of identified transport receptors and cognate cargo proteins. In mammalian cells, the lectin
C A Abbott et al.
European journal of biochemistry, 267(20), 6140-6150 (2000-09-30)
Dipeptidyl peptidase (DPP) IV has roles in T-cell costimulation, chemokine biology, type-II diabetes and tumor biology. Fibroblast activation protein (FAP) has been implicated in tumor growth and cirrhosis. Here we describe DPP8, a novel human postproline dipeptidyl aminopeptidase that is
Beat Nyfeler et al.
Traffic (Copenhagen, Denmark), 7(11), 1473-1481 (2006-10-03)
Exit of soluble secretory proteins from the endoplasmic reticulum (ER) can occur by receptor-mediated export as exemplified by blood coagulation factors V and VIII. Their efficient secretion requires the membrane lectin ER Golgi intermediate compartment protein-53 (ERGIC-53) and its soluble

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