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Merck
CN

D2915

Sigma-Aldrich

地塞米松-水溶性

suitable for cell culture, BioReagent

别名:

地塞米松-环糊精复合物

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About This Item

CAS号:
EC 号:
UNSPSC代码:
12352209
PubChem化学物质编号:
NACRES:
NA.77

生物来源

synthetic (organic)

质量水平

产品线

BioReagent

形式

solid

技术

cell culture | mammalian: suitable

溶解性

H2O: 25 mg/mL, clear to slightly hazy

运输

ambient

储存温度

room temp

SMILES字符串

C[C@@H]1CC2C3CCC4=CC(=O)C=C[C@]4(C)C3[C@@H](O)C[C@]2(C)[C@H]1C(=O)CO.OC[C@H]5O[C@@H]6O[C@H]7[C@H](O)[C@@H](O)[C@H](O[C@@H]7CO)O[C@H]8[C@H](O)[C@@H](O)[C@H](O[C@@H]8CO)O[C@H]9[C@H](O)[C@@H](O)[C@H](O[C@@H]9CO)O[C@H]%10[C@H](O)[C@@H](O)[C@H](O[C@@H]%10CO)O[C@H]%11[C@H](O)[C@@H](O)[C@H](O[C@@H]%11CO)O[C@H]%12[C@H](O)[C@@H](O)[C@H](O[C@@H]%12CO)O[C@H]5[C@H](O)[C@H]6O

InChI

1S/C42H70O35.C22H30O4/c43-1-8-29-15(50)22(57)36(64-8)72-30-9(2-44)66-38(24(59)17(30)52)74-32-11(4-46)68-40(26(61)19(32)54)76-34-13(6-48)70-42(28(63)21(34)56)77-35-14(7-49)69-41(27(62)20(35)55)75-33-12(5-47)67-39(25(60)18(33)53)73-31-10(3-45)65-37(71-29)23(58)16(31)51;1-12-8-16-15-5-4-13-9-14(24)6-7-21(13,2)20(15)17(25)10-22(16,3)19(12)18(26)11-23/h8-63H,1-7H2;6-7,9,12,15-17,19-20,23,25H,4-5,8,10-11H2,1-3H3/t8-,9-,10-,11-,12-,13-,14-,15-,16-,17-,18-,19-,20-,21-,22-,23-,24-,25-,26-,27-,28-,29-,30-,31-,32-,33-,34-,35-,36-,37-,38-,39-,40-,41-,42-;12-,15+,16?,17+,19-,20-,21+,22+/m11/s1

InChI key

XEJNDGTUKUMQNG-ARJMFYCQSA-N

相关类别

应用

水溶性地塞米松已被用作基于
  • Dulbeccos ′改良 Eagle 培养基的人间充质干细胞培养用成骨和脂肪形成培养基的成分
  • 用于肝脏、骨髓和脾脏组织生长的红系扩张培养基
  • 用于肝细胞培养的培养基 199 (M199)

生化/生理作用

地塞米松是一种抗炎糖皮质激素,也是一种用于治疗角膜炎症的合成皮质类固醇。它抑制 IL-1 β依赖性血管生成。地塞米松对细胞存活、细胞信号传导和基因表达具有一系列的影响。它促进软骨细胞的凋亡并损害骨骼的发育。地塞米松是一种潜在的治疗剂,因为它诱导多发性骨髓瘤 (MM) 细胞凋亡。它通过降低糖皮质激素受体 (GR) α水平并抑制结肠肿瘤进展来发挥其功能。

包装

包装规格取决于地塞米松

其他说明

每克含有约65 mg地塞米松;平衡甲基-β-环糊精。

象形图

Health hazard

警示用语:

Danger

危险声明

危险分类

Repr. 1B

储存分类代码

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

法规信息

监管及禁止进口产品

分析证书(COA)

输入产品批号来搜索 分析证书(COA) 。批号可以在产品标签上"批“ (Lot或Batch)字后找到。

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在文件库中查找您最近购买产品的文档。

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  1. What cell lines has Product D4902, Dexamethasone, been tested on?

    The cell lines on which this product is tested can vary from lot to lot. Some typically used cell lines are 3T3 fibroblasts, BHK, L929 and CHO.

  2. Are Products D4902 and D2915, sterile?

    No. This product is not sterile, but cell culture testing did not find the product to be toxic to cells.

  3. Which document(s) contains shelf-life or expiration date information for a given product?

    If available for a given product, the recommended re-test date or the expiration date can be found on the Certificate of Analysis.

  4. How do I get lot-specific information or a Certificate of Analysis?

    The lot specific COA document can be found by entering the lot number above under the "Documents" section.

  5. How long is Product D2915, Dexamethasone-Water Soluble, stable in solution?

    Dexamethasone solutions are stable for 6 months when aliquoted stored at -20 °C in a non-defrosting freezer and protected from light.  However, insufficient information is available to assess the shelf-life of solutions stored at 4°C.

  6. What is the molecular weight of Product D2915, Dexamethasone-Water Soluble?

    The molecular weight of dexamethasone alone is 392.5 g/mol. Be sure to take the weight of the carrier into account for any calculations involving molarity of solutions.

  7. How much Product D2915, Dexamethasone-Water Soluble, have I received?

    Each vial contains 100mg of Dexamethasone.  The milligrams of Dexamethasone per gram (Dexamethasone content) is listed on the Certificate of Analysis, which can be accessed through our Advanced Search Option.This information can be used to determine the conversion factor to make a solution of a given molarity.

  8. Can I use Product D2915, Dexamethasone-Water Soluble, to inject into mice?

    We do not perform animal studies with our products, but it can be used in cell culture.

  9. How should I reconstitute Product D2915, Dexamethasone-Water Soluble, for tissue culture use?

    The tissue culture grade product is tested in water at a concentration of 25 mg/mL forming a clear to slightly hazy colorless solution.

  10. Do you have references for the use of Product D2915, Dexamethason - Water Soluble?

    Here is one reference that describes using Product No. D2915: Chang, C.-J., et al., Coactivator TIF1? Interacts with Transcription Factor C/EBP? and Glucocorticoid Receptor To Induce ?1-Acid Glycoprotein Gene Expression. Mol. Cell. Biol., 18(10), 5880-5887 (1998).

  11. What is (2-Hydroxypropyl)-β-cyclodextrin contained in Product D2915?

    (2-Hydroxypropyl)-β-cyclodextrin is commonly used to get lipophilic drugs into aqueous solutions. This guest-host type complex is formed between the drug and the non-polar cavity in the HBC that results in enhanced solubility.

  12. Is the (2-Hydroxypropyl)-β-cyclodextrin contained in Product D2915, Dexammethasone - Water Soluble, toxic to cells?

    The carrier, (2-Hydroxypropyl)-β-cyclodextrin, has been found to be non-toxic to mice and rabbits.

  13. How do I find price and availability?

    There are several ways to find pricing and availability for our products. Once you log onto our website, you will find the price and availability displayed on the product detail page. You can contact any of our Customer Sales and Service offices to receive a quote.  USA customers:  1-800-325-3010 or view local office numbers.

  14. What is the Department of Transportation shipping information for this product?

    Transportation information can be found in Section 14 of the product's (M)SDS.To access the shipping information for this material, use the link on the product detail page for the product. 

  15. Can Product D2915, Dexamethasone - Water Soluble, be filter sterilized?

    This product can be filter sterilized through a 0.22 micron filter prior to use.

  16. My question is not addressed here, how can I contact Technical Service for assistance?

    Ask a Scientist here.

Immature erythroblasts with extensive ex vivo self-renewal capacity emerge from the early mammalian fetus
England SJ, et al.
Blood, 117(9), 2708-2717 (2011)
Dexamethasone-induced apoptotic mechanisms in myeloma cells investigated by analysis of mutant glucocorticoid receptors
Sharma S and Lichtenstein A
Blood, 112(4), 1338-1345 (2008)
Dexamethasone affects cell growthapoptosis chemosensitivity of colon cancer via glucocorticoid receptor alphaNF-kappaB
He J, et al.
Testing, 8(40), 67670-67670 (2017)
Plasma membrane phospholipase A2 controls hepatocellular fatty acid uptake and is responsive to pharmacological modulation: implications for nonalcoholic steatohepatitis
Stremmel W, et al.
Faseb Journal, 28(7), 3159-3170 (2014)
Mechanisms of dexamethasone-mediated inhibition of Toll-like receptor signaling induced by Neisseria meningitidis and Streptococcus pneumoniae
Mogensen TH, et al.
Infection and Immunity, 76(1), 189-197 (2008)

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