推荐产品
检测方案
≥98% (HPLC)
质量水平
形式
powder
溶解性
H2O: 5 mg/mL
抗生素抗菌谱
Gram-negative bacteria
Gram-positive bacteria
作用机制
DNA synthesis | interferes
enzyme | inhibits
储存温度
room temp
SMILES字符串
Cl.CN1CCN(CC1)c2cc3N(C=C(C(O)=O)C(=O)c3cc2F)c4ccc(F)cc4
InChI
1S/C21H19F2N3O3.ClH/c1-24-6-8-25(9-7-24)19-11-18-15(10-17(19)23)20(27)16(21(28)29)12-26(18)14-4-2-13(22)3-5-14;/h2-5,10-12H,6-9H2,1H3,(H,28,29);1H
InChI key
JFMGBGLSDVIOHL-UHFFFAOYSA-N
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一般描述
Chemical structure: fluoroquinolone
应用
Difloxacin is a fluoroquinolone antibiotic commonly used in veterinary medicine. It is a potential treatment for Chlamydia trachomatis infections and chronic Q fever in humans. It has been used to study how potential supplementation (magnesium) may reduce quinolone-induced damage in the horse and dog models.
生化/生理作用
Difloxacin inhibits bacterial DNA gyrase and the topoisomerase II enzyme, which inhibits DNA replication and transcription
Fluoroquinolone antibacterial compound.
其他说明
Keep container tightly closed in a dry and well-ventilated place.
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
Eyeshields, Gloves, type N95 (US)
J Segreti et al.
Antimicrobial agents and chemotherapy, 33(1), 118-119 (1989-01-01)
The in vitro activity of temafloxacin (A-62254), a new quinolone antibiotic, against 13 strains of Chlamydia trachomatis was determined and compared with those of doxycycline, norfloxacin, ciprofloxacin, and difloxacin. Temafloxacin and difloxacin were the most active quinolones tested, with bactericidal
In Vitro Evidence for Effects of Magnesium Supplementation on Quinolone-treated Horse and Dog Chondrocytes
M. Egerbacher, B. Wolfesberger, et al.
Veterinary Pathology, 29, 230-238 (2001)
S V Gollapudi et al.
Antimicrobial agents and chemotherapy, 30(3), 390-394 (1986-09-01)
Aryl-fluoroquinolone derivatives A-56619 (difloxacin) and A-56620 were found to inhibit human peripheral blood mononuclear cell (MNC) proliferation (measured by [3H]thymidine uptake) that was induced by concanavalin A or monoclonal antibody OKT3. These antimicrobial agents exert their maximum suppressive effect when
M R Yeaman et al.
Antimicrobial agents and chemotherapy, 33(7), 1052-1057 (1989-07-01)
Antibiotic susceptibility testing of two isolates of the Q-fever agent, Coxiella burnetii, was performed with recently and persistently infected L929 fibroblast cells. The two genetically distinct isolates, Nine Mile and Priscilla, are implicated in two different clinical disease syndromes, acute
D Moema et al.
Analytica chimica acta, 730, 80-86 (2012-05-29)
A simple and cost effective sample pre-treatment method, dispersive liquid-liquid microextraction (DLLME), has been developed for the extraction of six fluoroquinolones (FQs) from chicken liver samples. Clean DLLME extracts were analyzed for fluoroquinolones using liquid chromatography with diode array detection
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