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About This Item
经验公式（希尔记法）:
C21H19F2N3O3 · HCl
CAS号:
分子量:
435.85
MDL编号:
UNSPSC代码:
41116107
PubChem化学物质编号:
推荐产品
方案
≥98% (HPLC)
质量水平
表单
powder
溶解性
H2O: 5 mg/mL
抗生素抗菌谱
Gram-negative bacteria
Gram-positive bacteria
作用机制
DNA synthesis | interferes
enzyme | inhibits
储存温度
room temp
SMILES字符串
Cl.CN1CCN(CC1)c2cc3N(C=C(C(O)=O)C(=O)c3cc2F)c4ccc(F)cc4
InChI
1S/C21H19F2N3O3.ClH/c1-24-6-8-25(9-7-24)19-11-18-15(10-17(19)23)20(27)16(21(28)29)12-26(18)14-4-2-13(22)3-5-14;/h2-5,10-12H,6-9H2,1H3,(H,28,29);1H
InChI key
JFMGBGLSDVIOHL-UHFFFAOYSA-N
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一般描述
Chemical structure: fluoroquinolone
应用
Difloxacin is a fluoroquinolone antibiotic commonly used in veterinary medicine. It is a potential treatment for Chlamydia trachomatis infections and chronic Q fever in humans. It has been used to study how potential supplementation (magnesium) may reduce quinolone-induced damage in the horse and dog models.
生化/生理作用
Difloxacin inhibits bacterial DNA gyrase and the topoisomerase II enzyme, which inhibits DNA replication and transcription
Fluoroquinolone antibacterial compound.
其他说明
Keep container tightly closed in a dry and well-ventilated place.
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
Eyeshields, Gloves, type N95 (US)
J Segreti et al.
Antimicrobial agents and chemotherapy, 33(1), 118-119 (1989-01-01)
The in vitro activity of temafloxacin (A-62254), a new quinolone antibiotic, against 13 strains of Chlamydia trachomatis was determined and compared with those of doxycycline, norfloxacin, ciprofloxacin, and difloxacin. Temafloxacin and difloxacin were the most active quinolones tested, with bactericidal
In Vitro Evidence for Effects of Magnesium Supplementation on Quinolone-treated Horse and Dog Chondrocytes
M. Egerbacher, B. Wolfesberger, et al.
Veterinary Pathology, 29, 230-238 (2001)
M R Yeaman et al.
Antimicrobial agents and chemotherapy, 33(7), 1052-1057 (1989-07-01)
Antibiotic susceptibility testing of two isolates of the Q-fever agent, Coxiella burnetii, was performed with recently and persistently infected L929 fibroblast cells. The two genetically distinct isolates, Nine Mile and Priscilla, are implicated in two different clinical disease syndromes, acute
S V Gollapudi et al.
Antimicrobial agents and chemotherapy, 30(3), 390-394 (1986-09-01)
Aryl-fluoroquinolone derivatives A-56619 (difloxacin) and A-56620 were found to inhibit human peripheral blood mononuclear cell (MNC) proliferation (measured by [3H]thymidine uptake) that was induced by concanavalin A or monoclonal antibody OKT3. These antimicrobial agents exert their maximum suppressive effect when
Jianbin Guo et al.
Waste management (New York, N.Y.), 32(1), 131-136 (2011-08-27)
Antibiotics of inorganic and organic origin in pig manure can inhibit the anaerobic process in biogas plants. The influence of three frequently used antibiotics, copper dosed as CuSO(4), sulfadiazine (SDZ), and difloxacin (DIF), on the anaerobic digestion process of pig
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