D2696
去氢木香内酯
≥98% (HPLC)
别名:
(−)-脱氢肋内酯；脱氢肋内酯;环氧丙烷脱氢肋内酯, Guaia-4（15），10（14），11（13）-三烯-12-油酸，6α-羟基-，γ-内酯, [3aS-(3aα,6aα,9aα,9bβ)]-十氢-3,6,9-三（亚甲基）-薁并[4,5-b ]呋喃-2（3H）-酮, 脱氢肋内酯（6CI，7CI）, 脱氢肋骨内酯, （3aS，6aR，9aR，9bS）-十氢-3,6,9-三（亚甲基）-薁并[4,5-b]呋喃-2（3H）-酮
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所有图片(1)
About This Item
经验公式（希尔记法）:
C15H18O2
CAS号:
分子量:
230.30
MDL编号:
UNSPSC代码:
12352200
PubChem化学物质编号:
NACRES:
NA.77
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方案
≥98% (HPLC)
表单
powder
颜色
white to off-white
溶解性
DMSO: ≥20 mg/mL
储存温度
room temp
SMILES字符串
C=C1CC[C@@]2([H])C(CC[C@@H]3[C@H](OC(C3=C)=O)[C@]21[H])=C
InChI
1S/C15H18O2/c1-8-4-7-12-10(3)15(16)17-14(12)13-9(2)5-6-11(8)13/h11-14H,1-7H2/t11-,12-,13-,14-/m0/s1
InChI key
NETSQGRTUNRXEO-XUXIUFHCSA-N
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生化/生理作用
细胞因子信号传导（SOCS）蛋白的抑制因子负调节细胞因子受体信号传导。SOCS 系列包括 8 个成员，即 SOCS-1 至 SOCS-7 和 CIS。去氢木香内酯（DHE）是从雪莲和木香中提取的倍半萜内酯。该化合物具有抗真菌和抗分枝杆菌活性，并显示出对 HepG2、OVCAR-3 和 HeLa 细胞系的细胞毒性作用。DHE 不仅可以抑制早期乳腺癌 MCF-7 中的细胞增殖，还可以抑制更晚期 MDA-MB-231 癌细胞中的细胞增殖，而对 H184B5F5/M10 正常乳腺上皮细胞没有明显影响。对乳腺癌细胞增殖的抑制是通过细胞周期阻滞和凋亡发生的。 DHE 通过 SOCS-1 和 SOCS-3 抑制细胞周期进程和细胞死亡。
警示用语：
Warning
危险声明
危险分类
Skin Sens. 1
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
法规信息
新产品
Dan Wang et al.
Journal of Asian natural products research, 11(12), 991-996 (2010-02-26)
Aspergillus versicolor D-1 was employed to convert dehydrocostuslactone (1) and 3-hydroxy-1(10),3,11(13)-guaiatriene-12,6-olide-2-one (5) stereoselectively. The reactions occurring were specific hydrogenation on the exocyclic alpha,beta-double bond of sesquiterpene lactones with excellent conversion. Products were identified by the analysis of their spectra such
Jen-Yu Hung et al.
Lung cancer (Amsterdam, Netherlands), 68(3), 355-365 (2009-08-25)
This study investigates the anticancer effect of dehydrocostuslactone (DHE), a medicinal plant-derived sesquiterpene lactone, on human non-small cell lung cancer cell lines, A549, NCI-H460 and NCI-H520. Our results show that DHE inhibits the proliferation of A549, NCI-H460 and NCI-H520 cells.
Chih-Ya Wang et al.
PloS one, 7(2), e31195-e31195 (2012-02-24)
The traditional Chinese medicine component dehydrocostuslactone (DHC) isolated from Saussurea costus (Falc.) Lipschitz, has been shown to have anti-cancer activity. Angiogenesis is an essential process in the growth and progression of cancer. In this study, we demonstrated, for the first
Eun Mi Choi et al.
Toxicology in vitro : an international journal published in association with BIBRA, 23(5), 862-867 (2009-05-22)
Oxidative stress regulates cellular functions in multiple pathological conditions, including bone formation by osteoblasic cells. To elucidate the protective effects of dehydrocostus lactone on the response of osteoblast to oxidative stress, osteoblastic MC3T3-E1 cells were incubated with 0.3mM hydrogen peroxide
Ji Young Choi et al.
Molecules (Basel, Switzerland), 14(1), 266-272 (2009-01-13)
Activity-guided fractionation of a MeOH extract of the roots of Saussurea lappa C.B.Clarke (Compositae), using an in vitro protein tyrosine phosphatase 1B (PTP1B) inhibition assay, led to the isolation of four active constituents: betulinic acid (1), betulinic acid methyl ester
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