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Merck
CN
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主要文件

安全信息

D2189

Sigma-Aldrich

Recombinant CRM197 expressed in Pseudomonas fluorescens, [Glu52]- Diphtheria toxin

lyophilized powder

别名:

[Glu52]-Diphtheria toxin from Corynebacterium diphtheriae, CRM 197

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About This Item

CAS号:
92092-36-9
UNSPSC代码:
12352202

表单

lyophilized powder

质量水平

200

储存温度

2-8°C

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包装

Package size based on protein content

外形

Lyophilized powder containing sodium phosphate, sucrose and polysorbate 80

储存分类代码

11 - Combustible Solids

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

个人防护装备

Eyeshields, Gloves, type N95 (US)

法规信息

新产品

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number
SLBW3541
SLBV9634
SLBV5814
SLBT2959
SLBT0771

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  1. Which document(s) contains shelf-life or expiration date information for a given product?

    If available for a given product, the recommended re-test date or the expiration date can be found on the Certificate of Analysis.

  2. How do I get lot-specific information or a Certificate of Analysis?

    The lot specific COA document can be found by entering the lot number above under the "Documents" section.

  3. How do I reconstitute Product D2189, [Glu52]-Diphtheria toxin from Corynebacterium diphtheriae?

    The vial can be reconstituted with 1.0 mL of sterile water. Each vial contains 1 mg of Diphtheria toxin CRM mutant, sodium phosphate buffer, and lactose. It can sometimes be hard to get the product into solution due to the lactose used as a stabilizer. The supplier suggests slight warming (to at least room temperature or 30 °C, but not more than 37 °C) followed by a brief vortex to break up the filaments.   

  4. What kind of mutant, is Product D2189, [Glu52]-Diphtheria toxin from Corynebacterium diphtheriae, and how is this product different from Product No. D0564?

    Product No. D0564 is the wild-type toxin and possesses enzymatic activity.  The Glu52 diptheria toxin, also known as CRM197, has a mutation in fragment A (a glycine to glutamic acid substitution at position 52) that results in the complete loss of enzymatic activity. More information on the mutant can be found in the following reference: Uchida, T., Pappenheimer, Jr., A.M. and Harper, A.A.,  J. Biol. Chem., 248, 3851-3854 (1973).

  5. What is the molecular weight of Product D2189, [Glu52]-Diphtheria toxin from Corynebacterium diphtheriae?

    On reducing SDS gels, this protein migrates as a single band of an approximate molecular weight of 63,000 Daltons.      

  6. What is the Department of Transportation shipping information for this product?

    Transportation information can be found in Section 14 of the product's (M)SDS.To access the shipping information for this material, use the link on the product detail page for the product. 

  7. My question is not addressed here, how can I contact Technical Service for assistance?

    Ask a Scientist here.

Lucia H Lee et al.
Clinical and vaccine immunology : CVI, 19(4), 551-556 (2012-02-18)
New multivalent CRM(197)-based conjugate vaccines are available for childhood immunization. Clinical studies were reviewed to assess meningococcal group C (MenC) antibody responses following MenC-CRM(197) coadministration with CRM(197)-based pneumococcal or Haemophilus influenzae type b conjugate vaccines. Infants receiving a total CRM(197)
Christina S Chu et al.
Cancer immunology, immunotherapy : CII, 61(5), 629-641 (2011-10-25)
In spite of increased rates of complete response to initial chemotherapy, most patients with advanced ovarian cancer relapse and succumb to progressive disease. Immunotherapy may have potential for consolidation therapy. This randomized open-label phase I/II trial evaluated responses of patients
Pierre van Damme et al.
PloS one, 6(9), e25398-e25398 (2011-10-08)
Typhoid fever causes more than 21 million cases of disease and 200,000 deaths yearly worldwide, with more than 90% of the disease burden being reported from Asia. Epidemiological data show high disease incidence in young children and suggest that immunization
Francesca Micoli et al.
PloS one, 7(11), e47039-e47039 (2012-11-13)
Enteric fevers remain a common and serious disease, affecting mainly children and adolescents in developing countries. Salmonella enterica serovar Typhi was believed to cause most enteric fever episodes, but several recent reports have shown an increasing incidence of S. Paratyphi
Dodi Safari et al.
Vaccine, 29(38), 6498-6504 (2011-07-20)
Memory formation to CRM-neoglycoconjugate, a synthetic branched tetrasaccharide of Streptococcus pneumoniae type 14 polysaccharide (Pn14PS) that is conjugated to a CRM197 protein, was investigated using mice models. Mice were first immunized with the CRM-neoglycoconjugate and then boosted with either the
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