D2069
Desvenlafaxine Hydrochloride
≥98% (HPLC), powder
别名:
4-[2-(Dimethylamino)-1-(1-Hydroxycyclohexyl)Ethyl]-Phenol Hydrochloride
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关于此项目
经验公式（希尔记法）:
C16H25NO2 · HCl
化学文摘社编号:
分子量:
299.84
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352200
MDL number:
产品名称
Desvenlafaxine Hydrochloride, ≥98% (HPLC), powder
InChI
1S/C16H25NO2.ClH/c1-17(2)12-15(13-6-8-14(18)9-7-13)16(19)10-4-3-5-11-16;/h6-9,15,18-19H,3-5,10-12H2,1-2H3;1H
SMILES string
Cl.CN(C)CC(c1ccc(O)cc1)C2(O)CCCCC2
InChI key
IMWPSXHIEURNKZ-UHFFFAOYSA-N
assay
≥98% (HPLC)
form
powder
storage condition
desiccated
color
white to off-white
solubility
DMSO: >20 mg/mL
H2O: >20 mg/mL
originator
Wyeth
storage temp.
2-8°C
Quality Level
Application
Desvenlafaxine hydrochloride has been used to evaluate if its occurrence in drinking water at environmental concentrations could induce neuronal gene expression.
Biochem/physiol Actions
Desvenlafaxine hydrochloride is a dual SERT/NET reuptake inhibitor.
Desvenlafaxine hydrochloride is a dual SERT/NET reuptake inhibitor. It is a major active metabolite of venlafaxine (#542); brain penetrant; Ki = 40 nM and 122 nM for hSERT and hNET, respectively (weak binding at the hDAT). Inhibition of [3H]5-HT or [3H]NE uptake for the hSERT or hNET produced IC50 values of 47 and 531 nM.
Desvenlafaxine hydrochloride is a psychoactive drug. Incidence of this drug in environmental samples might induce in vitro gene expression associated with neurological disorders.
Features and Benefits
This compound is featured on the Biogenic Amine Transporters page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
This compound was developed by Wyeth. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.
signalword
Warning
hcodes
Hazard Classifications
Eye Irrit. 2
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
dust mask type N95 (US), Eyeshields, Gloves
法规信息
新产品
此项目有
Psychoactive pharmaceuticals at environmental concentrations induce in vitro gene expression associated with neurological disorders
Kaushik G, et al.
BMC Genomics, 17(3), 435-435 (2016)
Dysregulation of autism-associated synaptic proteins by psychoactive pharmaceuticals at environmental concentrations
Kaushik G, et al.
Neuroscience Letters, 661(3), 143-148 (2017)
Alessandro Atzei et al.
International journal of environmental research and public health, 18(13) (2021-07-03)
Humans are exposed daily to complex mixtures of chemical substances via food intake, inhalation, and dermal contact. Developmental neurotoxicity is an understudied area and entails one of the most complex areas in toxicology. Animal studies for developmental neurotoxicity (DNT) are
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