质量水平
检测方案
≥98% (HPLC)
形式
powder
储存条件
desiccated
颜色
white to off-white
溶解性
DMSO: >20 mg/mL
H2O: >20 mg/mL
创始人
Wyeth
储存温度
2-8°C
SMILES字符串
Cl.CN(C)CC(c1ccc(O)cc1)C2(O)CCCCC2
InChI
1S/C16H25NO2.ClH/c1-17(2)12-15(13-6-8-14(18)9-7-13)16(19)10-4-3-5-11-16;/h6-9,15,18-19H,3-5,10-12H2,1-2H3;1H
InChI key
IMWPSXHIEURNKZ-UHFFFAOYSA-N
应用
Desvenlafaxine hydrochloride has been used to evaluate if its occurrence in drinking water at environmental concentrations could induce neuronal gene expression.
生化/生理作用
Desvenlafaxine hydrochloride is a dual SERT/NET reuptake inhibitor. It is a major active metabolite of venlafaxine (#542); brain penetrant; Ki = 40 nM and 122 nM for hSERT and hNET, respectively (weak binding at the hDAT). Inhibition of [3H]5-HT or [3H]NE uptake for the hSERT or hNET produced IC50 values of 47 and 531 nM.
Desvenlafaxine hydrochloride is a psychoactive drug. Incidence of this drug in environmental samples might induce in vitro gene expression associated with neurological disorders.
特点和优势
This compound is featured on the Biogenic Amine Transporters page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
This compound was developed by Wyeth. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.
警示用语：
Warning
危险声明
危险分类
Eye Irrit. 2
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
dust mask type N95 (US), Eyeshields, Gloves
法规信息
新产品
Dysregulation of autism-associated synaptic proteins by psychoactive pharmaceuticals at environmental concentrations
Kaushik G, et al.
Neuroscience Letters, 661(3), 143-148 (2017)
Psychoactive pharmaceuticals at environmental concentrations induce in vitro gene expression associated with neurological disorders
Kaushik G, et al.
BMC Genomics, 17(3), 435-435 (2016)
Alessandro Atzei et al.
International journal of environmental research and public health, 18(13) (2021-07-03)
Humans are exposed daily to complex mixtures of chemical substances via food intake, inhalation, and dermal contact. Developmental neurotoxicity is an understudied area and entails one of the most complex areas in toxicology. Animal studies for developmental neurotoxicity (DNT) are
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