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Merck
CN
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文件

安全信息

D2043

Sigma-Aldrich

人防御素HNP-1

≥80% (HPLC)

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别名:
中性粒细胞肽1
经验公式（希尔记法）:
C150H222N44O38S6
CAS号:
99287-08-8
分子量:
3442.03
MDL编号:
MFCD00214572
UNSPSC代码:
12352202
PubChem化学物质编号:
329798727
NACRES:
NA.32

质量水平

200

检测方案

≥80% (HPLC)

形式

powder

组成

Peptide content, ~70%

溶解性

water: 1 mg/mL, clear, colorless

UniProt登记号

P59665

抗生素抗菌谱

fungi
mycobacteria
viruses

作用机制

cell membrane | interferes

储存温度

−20°C

SMILES字符串

CC[C@H](C)[C@@H]1NC(=O)[C@@H]2CSSC[C@@H]3NC(=O)[C@H](Cc4ccccc4)NC(=O)[C@H](C)NC(=O)[C@H](Cc5c[nH]c6ccccc56)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCNC(N)=N)NC(=O)CNC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](Cc7ccc(O)cc7)NC(=O)[C@@H](NC(=O)[C@H](CSSC[C@H](NC(=O)[C@H](Cc8ccc(O)cc8)NC(=O)[C@H](CSSC[C@H](NC3=O)C(O)=O)NC(=O)[C@H](C)N)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N9CCC[C@H]9C(=O)N[C@@H](C)C(=O)N2)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](Cc%10ccc(O)cc%10)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CCC(O)=O)NC(=O)CNC(=O)[C@H](C)NC1=O)[C@@H](C)O)[C@@H](C)CC

InChI

1S/C150H222N44O38S6/c1-14-74(6)116-142(227)171-78(10)121(206)166-64-112(200)173-97(49-51-115(203)204)129(214)175-93(32-23-53-162-148(155)156)127(212)174-94(33-24-54-163-149(157)158)128(213)180-99(59-83-36-42-87(196)43-37-83)125(210)168-66-114(202)190-119(81(13)195)144(229)188-108-71-236-233-68-105-136(221)176-95(34-25-55-164-150(159)160)130(215)193-118(76(8)16-3)145(230)194-56-26-35-110(194)141(226)170-80(12)123(208)185-107(139(224)191-116)70-235-234-69-106(138(223)189-109(146(231)232)72-238-237-67-104(184-120(205)77(9)151)137(222)181-101(135(220)186-105)60-84-38-44-88(197)45-39-84)187-134(219)100(58-82-27-18-17-19-28-82)178-122(207)79(11)169-131(216)103(62-86-63-165-91-30-21-20-29-90(86)91)182-132(217)98(57-73(4)5)179-126(211)92(31-22-52-161-147(153)154)172-113(201)65-167-124(209)96(48-50-111(152)199)177-133(218)102(61-85-40-46-89(198)47-41-85)183-143(228)117(75(7)15-2)192-140(108)225/h17-21,27-30,36-47,63,73-81,92-110,116-119,165,195-198H,14-16,22-26,31-35,48-62,64-72,151H2,1-13H3,(H2,152,199)(H,166,206)(H,167,209)(H,168,210)(H,169,216)(H,170,226)(H,171,227)(H,172,201)(H,173,200)(H,174,212)(H,175,214)(H,176,221)(H,177,218)(H,178,207)(H,179,211)(H,180,213)(H,181,222)(H,182,217)(H,183,228)(H,184,205)(H,185,208)(H,186,220)(H,187,219)(H,188,229)(H,189,223)(H,190,202)(H,191,224)(H,192,225)(H,193,215)(H,203,204)(H,231,232)(H4,153,154,161)(H4,155,156,162)(H4,157,158,163)(H4,159,160,164)/t74-,75-,76-,77-,78-,79-,80-,81+,92-,93-,94-,95-,96-,97-,98-,99-,100-,101-,102-,103-,104-,105-,106-,107-,108-,109-,110-,116-,117-,118-,119-/m0/s1

InChI key

KRJOFJHOZZPBKI-KSWODRSDSA-N

基因信息

human ... DEFA1(1667)

Amino Acid Sequence

Ala-Cys-Tyr-Cys-Arg-Ile-Pro-Ala-Cys-Ile-Ala-Gly-Glu-Arg-Arg-Tyr-Gly-Thr-Cys-Ile-Tyr-Gln-Gly-Arg-Leu-Trp-Ala-Phe-Cys-Cys [Disulfide bridges: 2−30; 4−19; 9−29]

一般描述

α-防御素基因，如DEFA1（防御素alpha 1）和DEFA3（防御素α 3），编码HNP-1、2和3（人中性粒细胞肽）。该基因定位于人染色体8p23.1上。
化学结构：肽

生化/生理作用

人中性粒细胞肽 (HNP) 参与动脉粥样硬化早期发展中的内皮损伤。HNP 1−3可调节动脉粥样硬化的生长。败血症和急性冠心病等炎症性疾病中的HNP 1−3浓度通常较高。
这是由人嗜中性粒细胞产生的内源性抗生素肽和单核细胞趋化肽。防御素是在哺乳动物吞噬细胞颗粒中发现的3-4kDa（29-34个氨基酸）肽家族。该家族成员富含精氨酸，它们均具有六个保守的半胱氨酸残基，参与形成分子内二硫键。

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

个人防护装备

Eyeshields, Gloves, type N95 (US)

法规信息

监管及禁止进口产品

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A J Ouellette
The American journal of physiology, 277(2 Pt 1), G257-G261 (1999-08-13)
The hypothesis that epithelial cells release preformed antibiotic peptides as components of mucosal innate immunity has gained experimental support in recent years. In the mammalian small intestine, Paneth cells secrete granules that are rich in alpha-defensins and additional antimicrobial peptides
Ryan J Blower et al.
PLoS neglected tropical diseases, 9(7), e0003862-e0003862 (2015-07-22)
Burkholderia thailandensis is a Gram-negative soil bacterium used as a model organism for B. pseudomallei, the causative agent of melioidosis and an organism classified category B priority pathogen and a Tier 1 select agent for its potential use as a
Copy number polymorphism and expression level variation of the human alpha-defensin genes DEFA1 and DEFA3
Aldred P M R, et al.
Human Molecular Genetics, 14(14), 2045-2052 (2005)
Lingli Tang et al.
Microbes and infection, 17(6), 402-408 (2015-03-11)
Chlamydia trachomatis infection in the lower genital tract, if untreated, can ascend to the upper genital tract, potentially leading to complications such as tubal factor infertility. The ascension involves cell-to-cell spreading, which may require C. trachomatis organisms to overcome mucosal
P S Hiemstra et al.
The European respiratory journal, 12(5), 1200-1208 (1998-12-24)
Neutrophils have the capacity to accumulate in high numbers in the lung during infection and inflammation. Because they play an important role in host defence against infection, but may also cause tissue injury, these cells are thought to be involved
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