D1944
D4476
≥98% (HPLC), solid
别名:
4-(4-(2,3-Dihydrobenzo[1,4]dioxin-6-yl)-5-pyridin-2-yl-1H-imidazol-2-yl)benzamide
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选择尺寸
关于此项目
经验公式（希尔记法）:
C23H18N4O3
化学文摘社编号:
分子量:
398.41
MDL number:
UNSPSC Code:
12352200
PubChem Substance ID:
NACRES:
NA.77
SMILES string
NC(=O)c1ccc(cc1)-c2nc(-c3ccccn3)c([nH]2)-c4ccc5OCCOc5c4
InChI
1S/C23H18N4O3/c24-22(28)14-4-6-15(7-5-14)23-26-20(21(27-23)17-3-1-2-10-25-17)16-8-9-18-19(13-16)30-12-11-29-18/h1-10,13H,11-12H2,(H2,24,28)(H,26,27)
InChI key
DPDZHVCKYBCJHW-UHFFFAOYSA-N
assay
≥98% (HPLC)
form
solid
color
light yellow
solubility
DMSO: ~20 mg/mL, H2O: insoluble
Quality Level
storage temp.
2-8°C
Application
D4476 has been used as a casein kinase I inhibitor (CKI) in various experiments.
Biochem/physiol Actions
D4476 is a potent, selective ATP-competitive inhibitor of CK1 (casein kinase 1).
D4476 may prevent or enhance apoptosis. It triggers tumor suppressor p53 and impairs transcription factor E2F-1.
Features and Benefits
This compound was developed by GlaxoSmithKline. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
Yuliya V Katlinskaya et al.
Molecular and cellular biology, 36(7), 1124-1135 (2016-01-27)
Wnt pathway-driven proliferation and renewal of the intestinal epithelium must be tightly controlled to prevent development of cancer and barrier dysfunction. Although type I interferons (IFN) produced in the gut under the influence of microbiota are known for their antiproliferative
Serine 235 is the primary NS5A hyperphosphorylation site responsible for hepatitis C virus replication
Hsu SC, et al.
Journal of Virology, 91(14), e00194-e00117 (2017)
CK1alpha suppresses lung tumour growth by stabilizing PTEN and inducing autophagy
Cai J, et al.
Nature Cell Biology, 20(4), 465-465 (2018)
Wei Yang et al.
Cell research, 27(12), 1466-1484 (2017-10-24)
Planar cell polarity (PCP) is an evolutionarily conserved essential mechanism that provides directional information to control and coordinate polarized cellular and tissue behavior during embryonic development. Disruption of PCP leads to severe morphological defects in vertebrates and its dysregulation results
Debapriya Bhattacharya et al.
The Journal of biological chemistry, 289(23), 16508-16515 (2014-04-09)
Tuberculosis remains the biggest infectious threat to humanity with one-third of the population infected and 1.4 million deaths and 8.7 million new cases annually. Current tuberculosis therapy is lengthy and consists of multiple antimicrobials, which causes poor compliance and high
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