所有图片(4)
别名:
甲基 L -多巴 盐酸盐
经验公式（希尔记法）:
C10H13NO4 · HCl
CAS号:
分子量:
247.68
MDL编号:
UNSPSC代码:
12352209
eCl@ss:
32160406
PubChem化学物质编号:
NACRES:
NA.77
推荐产品
形式
solid
质量水平
颜色
white to off-white
储存温度
−20°C
SMILES字符串
Cl[H].COC(=O)[C@@H](N)Cc1ccc(O)c(O)c1
InChI
1S/C10H13NO4.ClH/c1-15-10(14)7(11)4-6-2-3-8(12)9(13)5-6;/h2-3,5,7,12-13H,4,11H2,1H3;1H/t7-;/m0./s1
InChI key
WFGNJLMSYIJWII-FJXQXJEOSA-N
应用
L-3,4-二羟基苯丙氨酸甲酯盐酸盐用于：
- 治疗6-羟基多巴胺诱导的小鼠5-羟色胺神经元损伤
- 研究 B16F10 皮肤黑色素瘤细胞中酪氨酸酶活性
- 研究其对中脑神经元的神经保护作用
生化/生理作用
L-3,4-二羟基苯丙氨酸甲酯是 L-DOPA 的前体，可穿过血脑屏障。抗帕金森氏病药物 L-DOPA 甲酯在白血病和黑色素瘤中引发抗肿瘤功能。
注意
光敏性
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
L-Dopa methyl ester as a new antitumour agent
Wick MM
Nature, 269(5628), 512-513 (1977)
Muriel Geurts et al.
Neuroscience letters, 333(2), 146-150 (2002-11-07)
The role of dopaminergic transmission on striatal mRNA levels of regulators of G protein signalling proteins RGS 2-12 was evaluated by quantitative in situ hybridisation. A single injection of L-dopa (50 mg/kg i.p.) significantly increased the RGS2 mRNA level (by
Kevin W McCairn et al.
Journal of neurophysiology, 101(4), 1941-1960 (2009-01-24)
Competing theories seek to account for the therapeutic effects of high-frequency deep brain stimulation (DBS) of the internal globus pallidus (GPi) for medically intractable Parkinson's disease. To investigate this question, we studied the spontaneous activity of 102 pallidal neurons during
Xinxin Yang et al.
International journal of nanomedicine, 7, 2077-2086 (2012-05-24)
Levodopa remains the most effective drug in the treatment of Parkinson's disease. However, long-term administration of levodopa induces motor complications, such as levodopa-induced dyskinesia. The mechanisms underlying levodopa-induced dyskinesia are not fully understood. In this study, we prepared levodopa methyl
Intranasal administration of the dopaminergic agonists L-DOPA, amphetamine, and cocaine increases dopamine activity in the neostriatum: a microdialysis study in the rat
De Souza Silva MA, et al.
Journal of Neurochemistry, 68(1), 233-239 (1997)
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