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Merck
CN
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文件

D1415

Sigma-Aldrich

4,6-二氧庚酸

powder

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别名:
琥珀酰丙酮
线性分子式:
CH3COCH2COCH2CH2CO2H
CAS号:
51568-18-4
分子量:
158.15
MDL编号:
MFCD00002797
UNSPSC代码:
12352211
PubChem化学物质编号:
24893433
NACRES:
NA.25

形式

powder

质量水平

200

mp

66-67 °C (lit.)

脂质类型

saturated FAs

储存温度

2-8°C

SMILES字符串

CC(=O)CC(=O)CCC(O)=O

InChI

1S/C7H10O4/c1-5(8)4-6(9)2-3-7(10)11/h2-4H2,1H3,(H,10,11)

InChI key

WYEPBHZLDUPIOD-UHFFFAOYSA-N

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应用

4,6-二氧庚酸已用于：
  • 作为树突状细胞条件培养基组分并抑制树突状细胞中的ALA脱水酶(ALAD)(50)
  • 作为人单个核细胞(51)和HeLa细胞(52)中的血红素的生物合成抑制剂
  • 作为恶性疟原虫培养物中的琥珀酰丙酮的定量标准品(53)

生化/生理作用

4,6-二氧庚酸是一种血红素生物合成抑制剂。它是酪氨酸分解的代谢副产物，可抑制δ氨基酮戊酸(ALA)脱水酶。它是检测酪氨酸血症Ⅰ型的潜在标志物，是新生儿干血斑分析的检测目标。
血红素生物合成抑制剂

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WGK 3

闪点(°F)

Not applicable

闪点(°C)

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dust mask type N95 (US), Eyeshields, Gloves

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