D1415
4,6-二氧庚酸
powder
别名:
琥珀酰丙酮
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关于此项目
线性分子式:
CH3COCH2COCH2CH2CO2H
化学文摘社编号:
分子量:
158.15
NACRES:
NA.25
PubChem Substance ID:
UNSPSC Code:
12352211
MDL number:
InChI key
WYEPBHZLDUPIOD-UHFFFAOYSA-N
SMILES string
CC(=O)CC(=O)CCC(O)=O
InChI
1S/C7H10O4/c1-5(8)4-6(9)2-3-7(10)11/h2-4H2,1H3,(H,10,11)
form
powder
mp
66-67 °C (lit.)
lipid type
saturated FAs
storage temp.
2-8°C
Quality Level
Application
4,6-二氧庚酸已用于：
- 作为树突状细胞条件培养基组分并抑制树突状细胞中的ALA脱水酶(ALAD)(50)
- 作为人单个核细胞(51)和HeLa细胞(52)中的血红素的生物合成抑制剂
- 作为恶性疟原虫培养物中的琥珀酰丙酮的定量标准品(53)
Biochem/physiol Actions
4,6-二氧庚酸是一种血红素生物合成抑制剂。它是酪氨酸分解的代谢副产物，可抑制δ氨基酮戊酸(ALA)脱水酶。它是检测酪氨酸血症Ⅰ型的潜在标志物，是新生儿干血斑分析的检测目标。
血红素生物合成抑制剂
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
dust mask type N95 (US), Eyeshields, Gloves
lonp1-dependent Breakdown Of Mitochondrial 5-aminolevulinic Acid Synthase Protein By Heme In Human Liver Cells: 904
Tian Q, et al.
Hepatology, 54(4), 785A-785A (2011)
The effects of levulinic acid and 4, 6-dioxoheptanoic acid on the metabolism of etiolated and greening barley leaves
Meller E and Gassman ML
Plant Physiology, 67(4), 728-732 (1981)
Mark J Magera et al.
Molecular genetics and metabolism, 88(1), 16-21 (2006-02-02)
Tyrosinemia type I (TYR 1) is a severe disorder causing early death if left untreated. While tyrosine can be determined in dried blood spots (DBS), it is not a specific marker for TYR 1 and most often associated with benign
Amy Bergmann et al.
PLoS pathogens, 16(5), e1008499-e1008499 (2020-05-15)
Heme, an iron-containing organic ring, is essential for virtually all living organisms by serving as a prosthetic group in proteins that function in diverse cellular activities ranging from diatomic gas transport and sensing, to mitochondrial respiration, to detoxification. Cellular heme
Identification of a neonate with hepatorenal tyrosinemia by combined routine newborn screening for succinylacetone, acylcarnitines and amino acids.
Osama Y Al-Dirbashi et al.
Clinical biochemistry, 43(7-8), 691-693 (2009-10-20)
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