D1413
2′,3′-二脱氢-3′-脱氧胸苷
≥98% (TLC)
别名:
Stavudine
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关于此项目
经验公式（希尔记法）:
C10H12N2O4
化学文摘社编号:
分子量:
224.21
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352200
MDL number:
产品名称
2′,3′-二脱氢-3′-脱氧胸苷, ≥98% (TLC)
InChI
1S/C10H12N2O4/c1-6-4-12(10(15)11-9(6)14)8-3-2-7(5-13)16-8/h2-4,7-8,13H,5H2,1H3,(H,11,14,15)/t7-,8+/m0/s1
SMILES string
CC1=CN([C@@H]2O[C@H](CO)C=C2)C(=O)NC1=O
InChI key
XNKLLVCARDGLGL-JGVFFNPUSA-N
assay
≥98% (TLC)
form
powder
storage temp.
−20°C
Quality Level
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相关类别
Application
2′,3′-Didehydro-3′-deoxythymidine has been used in cell treatment. It has also been used as a drug in Caenorhabditis elegans to study drug induced mitochondrial toxicity. It has also been used in the preclinical evaluation of GS-9160.
Biochem/physiol Actions
2′,3′-Didehydro-3′-deoxythymidine is a nucleoside analog, which inhibits HIV replication in vitro. Stavudine has the ability to enter the cells by non-facilitated diffusion. It possesses inhibitory activity against moloney murine leukemia virus, friend murine leukemia virus and simian immunodeficiency virus.
General description
2′,3′-Didehydro-3′-deoxythymidine (d4T), a pyrimidine analogue is the inhibitor of reverse transcriptase.
存储类别
11 - Combustible Solids
wgk
WGK 2
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
Stephanie Shiau et al.
The Journal of pediatrics, 162(6), 1138-1145 (2013-01-15)
To describe the effects of age at antiretroviral therapy (ART) initiation on growth outcomes among children infected with HIV followed for 48 months after treatment initiation. This secondary analysis describes anthropometric changes in children infected with HIV in Johannesburg, South
2?, 3?-didehydro-3?-deoxythymidine (d4T) in patients with AIDS or AIDS-related complex: a phase I trial
Browne M J, et al.
The Journal of Infectious Diseases, 167(1), 21-29 (1993)
Caenorhabditis elegans as a model system for studying drug induced mitochondrial toxicity
de Boer R, et al.
PLoS ONE, 10(5), e0126220-e0126220 (2015)
Preclinical evaluation of GS-9160, a novel inhibitor of human immunodeficiency virus type 1 integrase
Jones G S, et al.
Antimicrobial Agents and Chemotherapy, 53(3), 1194-1203 (2009)
Nittaya Phanuphak et al.
Antiviral therapy, 17(8), 1521-1531 (2012-12-12)
Due to superior long-term toxicity profiles, zidovudine (AZT) and tenofovir disoproxil fumarate (TDF) are preferred over stavudine (d4T) for first-line antiretroviral regimens. However, short-term d4T use could be beneficial in avoiding AZT-induced anaemia. We randomized (1:1:1) 150 treatment-naive Thai HIV-infected
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