D1411
d-脱硫生物素
≥98% (TLC)
别名:
5-甲基-2-氧代-4-咪唑烷己酸
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关于此项目
经验公式（希尔记法）:
C10H18N2O3
化学文摘社编号:
分子量:
214.26
PubChem Substance ID:
eCl@ss:
34058011
UNSPSC Code:
12352200
NACRES:
NA.25
EC Number:
208-566-2
MDL number:
产品名称
d-脱硫生物素, ≥98% (TLC)
InChI key
AUTOLBMXDDTRRT-JGVFFNPUSA-N
InChI
1S/C10H18N2O3/c1-7-8(12-10(15)11-7)5-3-2-4-6-9(13)14/h7-8H,2-6H2,1H3,(H,13,14)(H2,11,12,15)/t7-,8+/m0/s1
SMILES string
C[C@@H]1NC(=O)N[C@@H]1CCCCCC(O)=O
assay
≥98% (TLC)
form
powder
storage temp.
2-8°C
Quality Level
Application
d-脱硫生物素已用作洗脱缓冲液组分：
- 在免疫共沉淀过程中从树脂上洗脱沉淀的蛋白质
- 在蛋白质层析纯化过程中洗脱人 Cdc45-MCM-GINS (CMG) 解旋酶
- 在层析纯化过程中，洗脱异二聚体驱动蛋白家族成员 3A/B (KIF3A/ B) 和驱动蛋白相关蛋白 3 (KAP3)-结合 APC armadillo (APCARM) 结构域
d-脱硫生物素已用于亲和层析和蛋白质层析。d-脱硫生物素可用于蛋白的标记、检测和分离。
Biochem/physiol Actions
脱硫生物素是一种不含硫的生物素衍生物，与生物素结合蛋白的结合强度较低，很容易被生物素移位。
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
Sudha Purushothaman et al.
PloS one, 3(5), e2320-e2320 (2008-05-30)
Fatty acids are indispensable constituents of mycolic acids that impart toughness & permeability barrier to the cell envelope of M. tuberculosis. Biotin is an essential co-factor for acetyl-CoA carboxylase (ACC) the enzyme involved in the synthesis of malonyl-CoA, a committed
M Sárdy et al.
Clinical chemistry, 45(12), 2142-2149 (1999-12-10)
Tissue transglutaminase (TGc) has recently been identified as the major, if not the sole, autoantigen of gluten-sensitive enteropathy (GSE). We developed and validated an ELISA based on the human recombinant antigen and compared it to existing serological tests for GSE
Rocio Rodriguez-Melendez et al.
The Journal of nutrition, 133(5), 1259-1264 (2003-05-06)
In mammals, biotin serves as a coenzyme for carboxylases such as propionyl-CoA carboxylase. The expression of genes encoding interleukin-2 (IL-2) and IL-2 receptor (IL-2R)gamma also depends on biotin. Biotin metabolites are structurally similar to biotin, and their concentrations in tissues
Bi-Huang Hu et al.
Analytical chemistry, 79(19), 7275-7285 (2007-08-24)
We describe a new method for encoded synthesis, efficient on-resin screening, and rapid unambiguous sequencing of combinatorial peptide libraries. An improved binary tag system for encoding peptide libraries during synthesis was designed to facilitate unequivocal assignment of isobaric residues by
S Voss et al.
Protein engineering, 10(8), 975-982 (1997-08-01)
The Strep-tag, an artificial peptide ligand of streptavidin, has gained use as an affinity handle for the purification and detection of recombinant fusion proteins. In an attempt to achieve tighter complexation of the peptide, streptavidin was engineered and the amino
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