D1285
2′,3′-脱氧腺苷
≥97% (HPLC)
别名:
Dideoxyadenosine, ddA
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关于此项目
经验公式（希尔记法）:
C10H13N5O2
化学文摘社编号:
分子量:
235.24
UNSPSC Code:
41106305
NACRES:
NA.51
PubChem Substance ID:
EC Number:
223-853-2
Beilstein/REAXYS Number:
619924
MDL number:
产品名称
2′,3′-脱氧腺苷, ≥97% (HPLC)
InChI
1S/C10H13N5O2/c11-9-8-10(13-4-12-9)15(5-14-8)7-2-1-6(3-16)17-7/h4-7,16H,1-3H2,(H2,11,12,13)/t6-,7+/m0/s1
InChI key
WVXRAFOPTSTNLL-NKWVEPMBSA-N
SMILES string
Nc1ncnc2n(cnc12)[C@H]3CC[C@@H](CO)O3
assay
≥97% (HPLC)
form
powder
optical activity
[α]/D -28.0±1.0
mp
181-184 °C (lit.)
solubility
water: 100 mg/mL, clear, colorless
storage temp.
2-8°C
Quality Level
Gene Information
human ... DCK(1633)
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Application
2′,3′-Dideoxyadenosine (ddA), a specific adenylyl cyclase inhibitor, is useful in biological process and pathway studies involving adenylyl cyclase activity and cAMP pool modulation.
General description
2′,3′-Dideoxyadenosine is a nucleoside analog of deoxyadenosine. On deamination, it is converted to dideoxyinosine. It inhibits adenylyl cyclase and may play a key role in the inhibition of tumor progression. It is a potent inhibitor of reverse transcriptase enzyme of human immunodeficiency virus.
存储类别
11 - Combustible Solids
wgk
WGK 2
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
Pharmacokinetics of 2′, 3′-dideoxyadenosine and 2′, 3′-dideoxyinosine in patients with severe human immunodeficiency virus infection
Hartman NR, et al.
Clinical Pharmacology and Therapeutics, 47(5), 647-654 (1990)
Christopher Tubbs et al.
Endocrinology, 150(1), 473-484 (2008-09-20)
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Elena Grossini et al.
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology, 23(1-3), 87-96 (2009-03-04)
Urocortin II has previously been shown in anesthetized pigs to increase coronary blood flow through activation of the endothelial nitric oxide synthase (eNOS) pathway and involvement of the subtype 2 of corticotropin releasing factor receptors (CRFR2). However, little information has
James N Wilson et al.
Chembiochem : a European journal of chemical biology, 9(2), 279-285 (2007-12-12)
Fluorescent nucleosides are widely used as probes of biomolecular structure and mechanism in the context of DNA, but they often exhibit low quantum yields because of quenching by neighboring DNA bases. Here we characterize the quenching by DNA of fluorescent
Mark Kwaaitaal et al.
The Biochemical journal, 440(3), 355-365 (2011-08-19)
Binding of specific microbial epitopes [MAMPs (microbe-associated molecular patterns)] to PRRs (pattern recognition receptors) and subsequent receptor kinase activation are key steps in plant innate immunity. One of the earliest detectable events after MAMP perception is a rapid and transient
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