推荐产品
表单
powder
颜色
white
溶解性
H2O: 3 mg/mL
SMILES字符串
[I-].C[N+]1(C)CCC(CC1)OC(=O)C(c2ccccc2)c3ccccc3
基因信息
human ... CHRM3(1131) , CHRM5(1133)
生化/生理作用
Muscarinic acetylcholine receptor antagonist with selectivity for the M3 amd M5 subtypes.
注意
Photosensitive
储存分类代码
13 - Non Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
Eyeshields, Gloves, type N95 (US)
法规信息
新产品
N Watson et al.
British journal of pharmacology, 127(2), 590-596 (1999-06-29)
1. Affinity estimates were obtained for several muscarinic antagonists against carbachol-stimulated [3H]-inositol phosphates accumulation in Chinese hamster ovary (CHO-KI) cells stably expressing either human muscarinic M3 or M5 receptor subtypes. The rationale for these studies was to generate a functional
H Moriya et al.
Life sciences, 64(25), 2351-2358 (1999-06-22)
A family of five subtypes of muscarinic acetylcholine receptors (mAChR) has been identified based on their molecular structures and second signal transduction pathways. In the present study, we examined the antagonist binding profiles of 9 muscarinic antagonists (atropine, 4-DAMP, pirenzepine
Yiming Zhang et al.
Cellular signalling, 23(6), 1057-1067 (2011-02-19)
Cobrotoxin (CbT), a short-chain postsynaptic α-neurotoxin, has been reported to play a role in analgesia. However, to date, the detailed mechanisms still remain unknown. In the present study, we identify a novel functional role of CbT in modulating T-type Ca(2+)
T M Cembala et al.
British journal of pharmacology, 125(5), 1088-1094 (1998-12-10)
1. Neuromuscular blocking drugs (NMBD's) are known to produce cardiovascular side effects manifesting as brady/tachycardias. In this study we have examined the interaction of a range of steroidal NMBD's with recombinant human m1-m5 muscarinic receptors expressed in Chinese hamster ovary
Jing Hu et al.
Journal of ethnopharmacology, 139(1), 136-141 (2011-11-24)
Crotonis Fructus is the mature fruit of Croton tiglium L. (Euphorbiaceae), which has been used in traditional Chinese medicine for the treatment of gastrointestinal (GI) diseases, such as constipation, abdominal pain, peptic ulcer, and intestinal inflammation for thousands of years.
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