D104
4-Diphenylacetoxy-N-methylpiperidine methiodide
powder
别名:
4-DAMP methiodide
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关于此项目
经验公式（希尔记法）:
C21H26INO2
化学文摘社编号:
分子量:
451.34
UNSPSC Code:
12352200
PubChem Substance ID:
MDL number:
SMILES string
[I-].C[N+]1(C)CCC(CC1)OC(=O)C(c2ccccc2)c3ccccc3
form
powder
color
white
solubility
H2O: 3 mg/mL
Gene Information
human ... CHRM3(1131), CHRM5(1133)
Biochem/physiol Actions
Muscarinic acetylcholine receptor antagonist with selectivity for the M3 amd M5 subtypes.
Disclaimer
Photosensitive
存储类别
13 - Non Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
法规信息
新产品
此项目有
H Moriya et al.
Life sciences, 64(25), 2351-2358 (1999-06-22)
A family of five subtypes of muscarinic acetylcholine receptors (mAChR) has been identified based on their molecular structures and second signal transduction pathways. In the present study, we examined the antagonist binding profiles of 9 muscarinic antagonists (atropine, 4-DAMP, pirenzepine
N Watson et al.
British journal of pharmacology, 127(2), 590-596 (1999-06-29)
1. Affinity estimates were obtained for several muscarinic antagonists against carbachol-stimulated [3H]-inositol phosphates accumulation in Chinese hamster ovary (CHO-KI) cells stably expressing either human muscarinic M3 or M5 receptor subtypes. The rationale for these studies was to generate a functional
A Koarai et al.
The European respiratory journal, 39(3), 698-704 (2011-09-03)
Macrophages increase in number and are highly activated in chronic obstructive pulmonary disease (COPD). Muscarinic receptor antagonists inhibit acetylcholine-stimulated release of neutrophilic chemoattractants, suggesting that acetylcholine may regulate macrophage responses. Therefore, expression and function of components of the non-neuronal cholinergic
Jing Hu et al.
Journal of ethnopharmacology, 139(1), 136-141 (2011-11-24)
Crotonis Fructus is the mature fruit of Croton tiglium L. (Euphorbiaceae), which has been used in traditional Chinese medicine for the treatment of gastrointestinal (GI) diseases, such as constipation, abdominal pain, peptic ulcer, and intestinal inflammation for thousands of years.
Christian Moro et al.
Urology, 78(6), 1442-1442 (2011-10-18)
To investigate the effects of tissue stretch and muscarinic receptor stimulation on the spontaneous activity of the urothelium/lamina propria and identify the specific receptor subtype mediating these responses. Isolated strips of porcine urothelium with lamina propria were set up for
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