所有图片(3)
About This Item
经验公式（希尔记法）:
C12H12IN
CAS号:
分子量:
297.13
MDL编号:
UNSPSC代码:
12352200
PubChem化学物质编号:
NACRES:
NA.77
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质量水平
方案
≥98% (HPLC)
表单
powder
储存条件
desiccated
颜色
white to beige
溶解性
H2O: 10 mg/mL, clear
SMILES字符串
[I-].C[n+]1ccc(cc1)-c2ccccc2
InChI
1S/C12H12N.HI/c1-13-9-7-12(8-10-13)11-5-3-2-4-6-11;/h2-10H,1H3;1H/q+1;/p-1
InChI key
RFDFRDXIIKROAI-UHFFFAOYSA-M
一般描述
1-甲基-4-苯基吡啶离子(MPP+)是一种选择性ERα拮抗剂。可通过抑制纹状体突触体中的线粒体氧化还原功能而诱发神经毒性。它是一种强效的神经毒素并可诱导动物帕金森症模型。它可通过在小脑颗粒神经元和神经母细胞瘤细胞中产生活性氧来介导细胞凋亡。MPP+可调控多巴胺的分布。它可通过激活神经元一氧化氮合酶（nNOS）而引起神经毒性，产生过量的一氧化氮。
应用
MPP+碘化物已用于：
- 在斑马鱼胚胎中诱导氧化应激
- 抑制星形胶质细胞线粒体中谷氨酸的摄入
- 在小胶质细胞（BV2）中使用MTT（3（4,5-二甲基噻唑）-2-基-2,5-二苯基四唑溴化物）检测细胞活力
生化/生理作用
MPP+碘化物是多巴胺能神经毒素MPTP的一种活性代谢物。
多巴胺能神经毒素MPTP的活性代谢物
注意
光敏感的。
制备说明
溶液应新鲜制备。
警示用语：
Danger
危险分类
Acute Tox. 3 Dermal - Acute Tox. 3 Inhalation - Acute Tox. 3 Oral - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
靶器官
Respiratory system
储存分类代码
6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges
历史批次信息供参考:
分析证书(COA)
Lot/Batch Number
JNK-mediated microglial DICER degradation potentiates inflammatory responses to induce dopaminergic neuron loss
Wang Q, et al.
Journal of Neuroinflammation, 15(1), 184-184 (2018)
1-Methyl-4-phenylpyridinium (MPP+)-induced apoptosis and mitochondrial oxidant generation: role of transferrin-receptor-dependent iron and hydrogen peroxide
Kalivendi SV, et al.
The Biochemical Journal, 371(1), 151-164 (2003)
Agnieszka Nikiforuk et al.
Frontiers in behavioral neuroscience, 11, 222-222 (2017-12-13)
Reduced cognitive abilities are often characterized by an impairment of flexibility, i.e., the ability to switch from learned rules or categories that were important in certain contexts to different new modalities that rule the task. Drugs targeting the dopamine transporter
Lack of PINK1 alters glia innate immune responses and enhances inflammation-induced, nitric oxide-mediated neuron death
Sun L, et al.
Scientific Reports, 8(1), 383-383 (2018)
Xi Yang et al.
Antimicrobial agents and chemotherapy, 60(10), 6260-6270 (2016-08-10)
Entecavir (ETV) is a first-line antiviral agent for the treatment of chronic hepatitis B virus infection. Renal excretion is the major elimination path of ETV, in which tubular secretion plays the key role. However, the secretion mechanism has not been
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