D048
MPP+碘化物
≥98% (HPLC), ERα antagonist, powder
别名:
1-甲基-4-苯基吡啶碘化物
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选择尺寸
关于此项目
经验公式（希尔记法）:
C12H12IN
化学文摘社编号:
分子量:
297.13
UNSPSC Code:
12352200
PubChem Substance ID:
NACRES:
NA.77
MDL number:
产品名称
MPP+碘化物, ≥98% (HPLC), powder
SMILES string
[I-].C[n+]1ccc(cc1)-c2ccccc2
InChI
1S/C12H12N.HI/c1-13-9-7-12(8-10-13)11-5-3-2-4-6-11;/h2-10H,1H3;1H/q+1;/p-1
InChI key
RFDFRDXIIKROAI-UHFFFAOYSA-M
assay
≥98% (HPLC)
form
powder
storage condition
desiccated
color
white to beige
solubility
H2O: 10 mg/mL, clear
Quality Level
相关类别
Application
MPP+碘化物已用于：
- 在斑马鱼胚胎中诱导氧化应激
- 抑制星形胶质细胞线粒体中谷氨酸的摄入
- 在小胶质细胞（BV2）中使用MTT（3（4,5-二甲基噻唑）-2-基-2,5-二苯基四唑溴化物）检测细胞活力
Biochem/physiol Actions
MPP+碘化物是多巴胺能神经毒素MPTP的一种活性代谢物。
多巴胺能神经毒素MPTP的活性代谢物
Disclaimer
光敏感的。
General description
1-甲基-4-苯基吡啶离子(MPP+)是一种选择性ERα拮抗剂。可通过抑制纹状体突触体中的线粒体氧化还原功能而诱发神经毒性。它是一种强效的神经毒素并可诱导动物帕金森症模型。它可通过在小脑颗粒神经元和神经母细胞瘤细胞中产生活性氧来介导细胞凋亡。MPP+可调控多巴胺的分布。它可通过激活神经元一氧化氮合酶（nNOS）而引起神经毒性，产生过量的一氧化氮。
Other Notes
Preparation Note
溶液应新鲜制备。
signalword
Danger
Hazard Classifications
Acute Tox. 3 Dermal - Acute Tox. 3 Inhalation - Acute Tox. 3 Oral - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
target_organs
Respiratory system
存储类别
6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges
Agnieszka Nikiforuk et al.
Frontiers in behavioral neuroscience, 11, 222-222 (2017-12-13)
Reduced cognitive abilities are often characterized by an impairment of flexibility, i.e., the ability to switch from learned rules or categories that were important in certain contexts to different new modalities that rule the task. Drugs targeting the dopamine transporter
JNK-mediated microglial DICER degradation potentiates inflammatory responses to induce dopaminergic neuron loss
Wang Q, et al.
Journal of Neuroinflammation, 15(1), 184-184 (2018)
1-Methyl-4-phenylpyridinium (MPP+)-induced apoptosis and mitochondrial oxidant generation: role of transferrin-receptor-dependent iron and hydrogen peroxide
Kalivendi SV, et al.
The Biochemical Journal, 371(1), 151-164 (2003)
Bart de Nijs et al.
Nature communications, 8(1), 994-994 (2017-10-24)
Nanoparticles attached just above a flat metallic surface can trap optical fields in the nanoscale gap. This enables local spectroscopy of a few molecules within each coupled plasmonic hotspot, with near thousand-fold enhancement of the incident fields. As a result
1-Methyl-4-phenylpyridinium (MPP+) decreases mitochondrial oxidation-reduction (REDOX) activity and membrane potential (DeltaPsim) in rat striatum
Nakai M, et al.
Experimental Neurology, 179(1), 103-110 (2003)
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