一般描述
Novozymes Corp.的产品
葡聚糖酶由许多微生物产生，包括细菌、丝状真菌和酵母。
应用
来自毛壳菌的葡聚糖酶已被用于：
- 微载体溶解以产生药物发现用多细胞 3D 球体
- 细菌分离物中细胞外多糖（EPS）的体外消化
- 葡聚糖酶固定化的研究
- 研究交替糖酶促修饰工艺条件的优化
生化/生理作用
葡聚糖酶是一种水解葡聚糖中α-(1,6)-糖苷键的内葡聚糖酶。它具有许多工业和临床应用，例如食品加工、糖修饰和药物制备。葡聚糖酶广泛用于生产交替甜菜和异麦芽寡糖（IMO），这是一种益生功能食品。从葡聚糖酶获得的低分子量葡聚糖可用作合成血容量扩充剂。葡聚糖酶可与抗体偶联以检测肿瘤细胞。它通过使牙齿中的微生物葡聚糖沉积物解聚来防止牙菌斑的发生。因此，它被用于牙科护理产品。
制备说明
通过Chaetomium erraticum的深层发酵产生的一种真菌葡聚糖酶。
分析说明
在pH 3-7范围内以及最高约70 °C的温度下稳定。对于绝大多数应用，比较适合的条件是pH 5-6且 50-60 °C的温度。
其他说明
警示用语：
Danger
危险声明
预防措施声明
危险分类
Resp. Sens. 1
WGK
WGK 1
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
Eyeshields, Gloves, type N95 (US)
法规信息
常规特殊物品
F Abeille et al.
Lab on a chip, 14(18), 3510-3518 (2014-07-12)
Microfluidic bioreactors are expected to impact cell therapy and biopharmaceutical production due to their ability to control cellular microenvironments. This work presents a novel approach for continuous cell culture in a microfluidic system. Microcarriers (i.e., microbeads) are used as growth
Co-immobilization of dextransucrase and dextranase in epoxy-agarose-tailoring oligosaccharides synthesis
da Silva R, et al.
Process Biochemistry (Oxford, United Kingdom), 78, 71-81 (2019)
Laura Montani et al.
Methods in molecular biology (Clifton, N.J.), 827, 305-317 (2011-12-07)
In contrast to typical Rho GTPases the regulation of atypical Rho GTPases, such as the members of the RhoBTB subfamily, rarely depends on GEFs and/or GAPs. Instead, they are regulated at the level of their expression, by post-translational modifications, by
Kinetics and thermodynamic of the purified dextranase from Chaetomium erraticum
Virgen-Ortiz JJ, et al.
Journal of Molecular Catalysis. B, Enzymatic, 122, 80-86 (2015)
Frank Alwin Erhardt et al.
Journal of biotechnology, 131(4), 440-447 (2007-09-19)
In order to facilitate the Co-Immobilization of dextransucrase and dextranase, various techniques for the immobilization of industrial endo-dextranase from Chaetomium erraticum (Novozymes A/S) were researched. Adsorption isotherms at various pH-values have been determined for bentonite (Montmorillonite), hydroxyapatite and Streamline DEAE.
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