D002
(±)-2-Amino-6,7-dihydroxy-1,2,3,4-tetrahydronaphthalene hydrobromide
solid
别名:
6,7-ADTN hydrobromide
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关于此项目
经验公式（希尔记法）:
C10H13NO2 · HBr
化学文摘社编号:
分子量:
260.13
UNSPSC Code:
12352200
PubChem Substance ID:
MDL number:
SMILES string
Br[H].NC1CCc2cc(O)c(O)cc2C1
form
solid
storage condition
protect from light
solubility
H2O: >10 mg/mL (Dissolve in oxygen-free water containing 0.1% sodium metabisulfite or other antioxidants.), aqueous base: unstable
storage temp.
2-8°C
Gene Information
human ... DRD1(1812), DRD2(1813), DRD3(1814), DRD4(1815), DRD5(1816)
Biochem/physiol Actions
Dopamine receptor agonist.
Disclaimer
Air- and light-sensitive
signalword
Warning
hcodes
Hazard Classifications
Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
target_organs
Respiratory system
存储类别
13 - Non Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
dust mask type N95 (US), Eyeshields, Gloves
法规信息
新产品
此项目有
Regan Ashby et al.
Experimental eye research, 85(1), 15-22 (2007-05-15)
Increases in the expression of the immediate early gene ZENK in the retina, measured by changes in the levels of mRNA and protein immunoreactivity, are amongst the most rapid responses so far measured to conditions that decrease the rate of
K S Sugamori et al.
FEBS letters, 362(2), 131-138 (1995-04-03)
We report here the isolation from Drosophila melanogaster of a 2.0 kb cDNA clone encoding a 385 amino acid protein (dDA1) displaying, within putative transmembrane domains, highest amino acid sequence homology (49-53%) to members of the vertebrate dopamine D1-like receptor
B H Rohde et al.
Current eye research, 8(12), 1225-1231 (1989-12-01)
A binding site for tritiated 2-amino-6, 7-dihydroxy-1, 2,3,4-tetrahydronaphthalene (ADTN) has been partially characterized in the rabbit iris root-ciliary body. Binding of ADTN is proportional to protein content and requires at least 60 minutes to reach equilibrium. Binding is saturable, with
U Sreenivasan et al.
Journal of medicinal chemistry, 36(2), 256-263 (1993-01-22)
A series of analogues of the potent analogue of Pro-Leu-Gly-NH2 (PLG), 2-oxo-3(R)-[(2(S)-pyrrolidinylcarbonyl)amino]-1-pyrrolidineacet amide (2) were synthesized in which the (R)-gamma-lactam residue of 2 was replaced with a (R)-beta-lactam, (R)-aminosuccinimide, (R)-cycloseryl, (R)-delta-lactam, (R)-epsilon-lactam, or (S)-epsilon-lactam residue to give analogues 3-8, respectively.
G M Ross et al.
Journal of molecular neuroscience : MN, 4(3), 141-148 (1993-01-01)
Several pharmacologically active catecholamines have been shown to react covalently with CNS proteins, namely species of 47, 40, 22, and 20 kDa. Of these, the 47-kDa protein showed the greatest incorporation of tritium following treatment with [3H]dopamine, [3H]ADTN, or [3H]N-propyl-norapomorphine.
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