CNSBR003
新生霉素 钠盐
≥850 μg/mg dry basis, powder
别名:
Albamycin, Albamycin sodium, Cathomycin sodium
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关于此项目
经验公式（希尔记法）:
C31H35N2NaO11
化学文摘社编号:
分子量:
634.61
UNSPSC Code:
51101500
Beilstein/REAXYS Number:
3892910
InChI key
AXOUUAINTJNFRS-UHFFFAOYSA-N
InChI
1S/C31H35N2O11.Na/c1-14(2)7-8-16-13-17(9-11-19(16)34)27(37)33-21-22(35)18-10-12-20(15(3)24(18)42-28(21)38)41-29-23(36)25(43-30(32)39)26(40-6)31(4,5)44-29;/h7,9-13,23,25-26,29,34,36H,8H2,1-6H3,(H2,32,39)(H,33,37);/q-1;+1
SMILES string
[Na+].CO[C@@H]1[C@@H](OC(N)=O)[C@@H](O)[C@H](Oc2ccc3C([O-])=C(NC(=O)c4ccc(O)c(C\C=C(\C)C)c4)C(=O)Oc3c2C)OC1(C)C
assay
≥850 μg/mg dry basis
form
powder
color
white to off-white
antibiotic activity spectrum
Gram-positive bacteria
mode of action
DNA synthesis | interferes, enzyme | inhibits
storage temp.
2-8°C
Quality Level
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General description
Novobiocin sodium salt is an antibiotic derived from soil bacteria. Novobiocin inhibits the action of bacterial DNA gyrase and belongs to a class of compounds called coumarin antibiotics. Coumarins are heterocyclic compounds with a wide range of biological activity, including antibacterial, anticoagulant, antioxidant, anti-inflammatory, antiviral, antitumor, and enzyme inhibitory effects.
Application
For the production of positively supercoiled plasmid DNA. Inhibitor of bacterial DNA gyrase and eukaryotic DNA topoisomerase. Inhibitor of retrovirus RNA-dependent DNA-polymerase.
Novobiocin Sodium Salt, an inhibitor of Hsp90, can be used: in the research heat shock protein inhibition and to produce positively supercoiled plasmid DNA.
Biochem/physiol Actions
Mode of Action: Inhibits DNA synthesis by inhibiting the enzyme Topoisomerase II.
Antimicrobial spectrum: Gram-positive bacterial.
Antimicrobial spectrum: Gram-positive bacterial.
Novobiocin inhibits DNA synthesis by inhibiting the GyrB subunit of the Topoisomerase enzyme involved in energy transduction.
Features and Benefits
High quality antibiotic suitable for mulitple research applications.
signalword
Warning
hcodes
Hazard Classifications
Acute Tox. 4 Oral - Eye Irrit. 2 - Skin Sens. 1
存储类别
11 - Combustible Solids
wgk
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
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