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主要文件

安全信息

C9983

Sigma-Aldrich

肌酸激酶BB级分 人

≥90% (SDS-PAGE), liquid, recombinant, expressed in Pichia pastoris

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About This Item

MDL编号:
MFCD02677919
UNSPSC代码:
12352204
eCl@ss:
32160410
NACRES:
NA.54

重组

expressed in Pichia pastoris

质量水平

200

方案

≥90% (SDS-PAGE)

表单

liquid

分子量

35-50 kDa

浓度

≥1.0 mg/mL

UniProt登记号

P12277

储存温度

−70°C

基因信息

human ... CKB(1152)

一般描述

溶于50%甘油、Tris缓冲液（含10 mM Bis-Tris-HCl、0.5 mM DTT、0.5 mM EDTA）

应用

人肌酸激酶BB部分已被用于研究急性心肌梗死后晚期经皮冠状血管介入治疗对患者的生存益处。人肌酸激酶BB组分也已用于分析蛋白氧化和由此导致的功能损失的研究中。

生化/生理作用

本品用作ELISA法监测脑脊液水平的对照品。肌酸激酶（CK）BB是CK基因家族的成员，是大脑中存在的胞质CK同工型。实测分子量为35-50 kDa。CKs催化ATP和肌酸之间磷酸基的可逆转移。它在神经细胞ATP水平的调节中起重要作用。因此，CK BB活性的降低是与年龄相关的神经退行性疾病（例如阿尔茨海默氏病，皮克氏病和路易体痴呆）中CNS细胞损伤的生化标志之一。

单位定义

一个单位将在37℃下每分钟将1.0 μmole磷酸盐从磷酸肌酸转移至ADP（在340 nm处测量，以偶联反应产生1等摩尔量的NADH计）。

储存分类代码

10 - Combustible liquids

WGK

WGK 2

闪点(°F)

Not applicable

闪点(°C)

Not applicable

法规信息

常规特殊物品

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number
SLCF5894
SLCC8473
SLCC4136
SLBX6266
SLBV8655

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  1. Which document(s) contains shelf-life or expiration date information for a given product?

    If available for a given product, the recommended re-test date or the expiration date can be found on the Certificate of Analysis.

  2. How do I get lot-specific information or a Certificate of Analysis?

    The lot specific COA document can be found by entering the lot number above under the "Documents" section.

  3. How do I find price and availability?

    There are several ways to find pricing and availability for our products. Once you log onto our website, you will find the price and availability displayed on the product detail page. You can contact any of our Customer Sales and Service offices to receive a quote.  USA customers:  1-800-325-3010 or view local office numbers.

  4. What is the Department of Transportation shipping information for this product?

    Transportation information can be found in Section 14 of the product's (M)SDS.To access the shipping information for this material, use the link on the product detail page for the product. 

  5. What does the "BB" stand for in "Creatine Kinase BB Fraction Human", product C9983?

    Creatine Kinase is a dimer that exists as three isozymes:  MM (muscle), MB (hybrid) and BB (brain). Product C9983, Creatine Kinase BB Fraction Human, refers to the brain isozyme.

  6. My question is not addressed here, how can I contact Technical Service for assistance?

    Ask a Scientist here.

Loïc Dayon et al.
Analytical chemistry, 80(8), 2921-2931 (2008-03-04)
A new 6-plex isobaric mass tagging technology is presented, and proof of principle studies are carried out using standard protein mixtures and human cerebrospinal fluid (CSF) samples. The Tandem Mass Tags (TMT) comprise a set of structurally identical tags which
M Aksenov et al.
Journal of neurochemistry, 74(6), 2520-2527 (2000-05-23)
Creatine kinase (CK) BB, a member of the CK gene family, is a predominantly cytosolic CK isoform in the brain and plays a key role in regulation of the ATP level in neural cells. CK BB levels are reduced in
T Talvik et al.
Acta paediatrica (Oslo, Norway : 1992), 84(10), 1183-1187 (1995-10-01)
Creatine kinase isoenzyme BB was determined in cerebrospinal fluid (CSF) in 79 preterm neonates using an original enzyme-linked immunosorbent assay. The criterion for inclusion was an Apgar score of 7 or less at 5 min of life. Neurological examination was
Bozidarka Knezević et al.
Bosnian journal of basic medical sciences, 9(1), 54-58 (2009-03-17)
The impact of late percutaneous coronary intervention (PCI) in the patients after acute myocardial infarction (AMI) on long term mortality remains to be established. At currently, thrombolysis is accepted as standard therapy when PCI is not immediately available. However, PCI
Paul D Hamilton et al.
Biochemistry and biophysics reports, 22, 100748-100748 (2020-03-11)
Creatine kinase (CK) is an energy storage enzyme that plays an important role in energy metabolism. CK/phosphocreatine functions as an energy buffer and links ATP production sites with ATP utilization sites. Several key mutations in the αA-crystallin (cryaa) and αB-crystallin
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Chromatograms

application for HPLC

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