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安全信息

C9801

Sigma-Aldrich

酪蛋白,N,N-二甲基化 来源于牛奶

essentially salt-free, lyophilized powder

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别名:
N,N-dimethylcasein
CAS号:
MDL编号:
UNSPSC代码:
12352202
NACRES:
NA.61

生物来源

bovine milk

质量水平

检测方案

≥90% (colorimetric)

形式

essentially salt-free, lyophilized powder

技术

activity assay: suitable

UniProt登记号

储存温度

−20°C

InChI

1S/C81H125N22O39P/c1-36(2)31-50(76(132)94-43(15-24-57(87)108)71(127)101-52(34-64(120)121)78(134)98-49(81(137)138)11-7-8-30-82)99-72(128)47(19-28-61(114)115)95-77(133)51(33-63(118)119)100-73(129)48(20-29-62(116)117)97-80(136)65(37(3)104)103-75(131)44(16-25-58(88)109)92-68(124)42(14-23-56(86)107)90-67(123)41(13-22-55(85)106)91-69(125)45(17-26-59(110)111)93-70(126)46(18-27-60(112)113)96-79(135)53(35-142-143(139,140)141)102-74(130)40(12-21-54(84)105)89-66(122)39(83)32-38-9-5-4-6-10-38/h4-6,9-10,36-37,39-53,65,104H,7-8,11-35,82-83H2,1-3H3,(H2,84,105)(H2,85,106)(H2,86,107)(H2,87,108)(H2,88,109)(H,89,122)(H,90,123)(H,91,125)(H,92,124)(H,93,126)(H,94,132)(H,95,133)(H,96,135)(H,97,136)(H,98,134)(H,99,128)(H,100,129)(H,101,127)(H,102,130)(H,103,131)(H,110,111)(H,112,113)(H,114,115)(H,116,117)(H,118,119)(H,120,121)(H,137,138)(H2,139,140,141)

InChI key

BECPQYXYKAMYBN-UHFFFAOYSA-N

一般描述

酪蛋白是一种牛奶蛋白,平价无毒,高度稳定。牛乳中,这种磷蛋白占总蛋白的80%。分泌性钙结合磷蛋白家族众多,酪蛋白是其中一个较大家族的成员。

应用

从牛乳中提取的 N,N-二甲基酪蛋白,可用于:
  • 确定一般蛋白水解活性
  • 作为底物,研究去磷酸化对双股螺旋丝(PHF)II-τ钙激活中性蛋白酶(CANP)蛋白水解的影响
  • 转谷氨酰胺酶(TG)试验

牛乳中的酪蛋白、N,N-二甲基化可用于检测和帮助确定组织转谷氨酰胺酶 (tTG) 在疾病中的功能角色。特别是酪蛋白,N,N-二甲基化已经被用于蛋白质底物上 tTG 的力学和动力学分析,这可能与神经退行性疾病有关。

与非甲基化酪蛋白相比,该制剂与 2,4,6-三硝基苯磺酸 (TNBS) 的反应性低于 10%。

用于检测 basilase 的蛋白酶底物和通过定点突变产生的枯草杆菌蛋白酶类似物。

生化/生理作用

酪蛋白是药物递送载体的优选物质。具有抗氧化活性。

制备说明

通过 Cabacungan,J.C.等人的方法对 C5890 进行还原甲基化。Anal. Biochem,124,272 (1982)。

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

个人防护装备

Eyeshields, Gloves, type N95 (US)

法规信息

动植物源性产品

分析证书(COA)

输入产品批号来搜索 分析证书(COA) 。批号可以在产品标签上"批“ (Lot或Batch)字后找到。

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  1. How does the storage temperature relate to shipping conditions?

    The storage conditions that a Sigma-Aldrich catalog and label recommend for products are deliberately conservative. For many products, long-term storage at low temperatures will increase the time during which they are expected to remain in specification and therefore are labeled accordingly. Where short-term storage, shipping time frame, or exposure to conditions other than those recommended for long-term storage will not affect product quality, Sigma-Aldrich will ship at ambient temperature. The products sensitive to short-term exposure to conditions other than their recommended long-term storage are shipped on wet or dry ice. Ambient temperature shipping helps to control shipping costs for our customers. At any time, our customers can request wet- or dry-ice shipment, but the special handling is at customer expense if our product history indicates that the product is stable for regular shipment. See Shipping and Storage for more information.

  2. Which document(s) contains shelf-life or expiration date information for a given product?

    If available for a given product, the recommended re-test date or the expiration date can be found on the Certificate of Analysis.

  3. How do I get lot-specific information or a Certificate of Analysis?

    The lot specific COA document can be found by entering the lot number above under the "Documents" section.

  4. How do I find price and availability?

    There are several ways to find pricing and availability for our products. Once you log onto our website, you will find the price and availability displayed on the product detail page. You can contact any of our Customer Sales and Service offices to receive a quote.  USA customers:  1-800-325-3010 or view local office numbers.

  5. What is the Department of Transportation shipping information for this product?

    Transportation information can be found in Section 14 of the product's (M)SDS.To access the shipping information for this material, use the link on the product detail page for the product. 

  6. What is Product C9801, N,N-dimethylated casein, soluble in?

    The solubility has been tested at 10mg/mL in 0.1M Boric acid, resulting in a white haze.

  7. What is the molecular weight of Product C9801, N,N-dimethylated casein?

    Unfortunately, we have not determined the molecular weight. The molecular weight of casein is 26 kDa or less; the molecular weight of Product No. C9801 is expected to be a bit higher.

  8. What is the purity of Product No. C9801, N,N-dimethylated casein?

    This product is not sold by purity, but by the percent of N,N-methylation. It is required to be at least 90% methylated.

  9. My question is not addressed here, how can I contact Technical Service for assistance?

    Ask a Scientist here.

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