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Merck
CN
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文件

安全信息

C9705

Sigma-Aldrich

刀豆素A

≥70% (HPLC)

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别名:
福霉素
经验公式（希尔记法）:
C46H75NO14
CAS号:
80890-47-7
分子量:
866.09
Beilstein:
3560277
MDL编号:
MFCD00210037
UNSPSC代码:
12352200
PubChem化学物质编号:
24893186
NACRES:
NA.77

质量水平

200

检测方案

≥70% (HPLC)

形式

solid film

抗生素抗菌谱

viruses

作用机制

enzyme | inhibits

储存温度

−20°C

SMILES字符串

CCC1C(O)C(C)C\C(C)=C\C=C\C(OC)C(OC(=O)\C(OC)=C\C(C)=C\C(C)C1O)C(C)C(O)C(C)[C@]2(O)C[C@@H](O[C@H]3C[C@@H](O)[C@H](OC(N)=O)[C@@H](C)O3)[C@H](C)C(O2)\C=C\C

InChI

1S/C46H75NO14/c1-13-16-34-28(7)37(58-38-22-33(48)43(31(10)57-38)60-45(47)53)23-46(54,61-34)30(9)41(51)29(8)42-35(55-11)18-15-17-24(3)19-26(5)39(49)32(14-2)40(50)27(6)20-25(4)21-36(56-12)44(52)59-42/h13,15-18,20-21,26-35,37-43,48-51,54H,14,19,22-23H2,1-12H3,(H2,47,53)/b16-13+,18-15+,24-17+,25-20+,36-21-/t26?,27?,28-,29?,30?,31-,32?,33-,34?,35?,37-,38+,39?,40?,41?,42?,43-,46+/m1/s1

InChI key

DJZCTUVALDDONK-LWLXYWDNSA-N

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相关类别

一般描述

刀豆素A属于plecomacrolide家族一员，由18元四烯大环内酯环构成。
化学结构：大环内酯

应用

刀豆素A已用于：
  • 作为新老成纤维细胞的溶酶体抑制剂
  • 作为突触前囊泡的液泡型H+-ATP酶抑制剂
  • 作为HepG2肝细胞的溶酶体酸化抑制剂

生化/生理作用

刀豆素A(ConA)抑制细胞器的酸化和穿孔素介导的细胞毒性。它是一种液泡型v-ATP酶抑制剂。刀豆素A具有抗原虫和抗肿瘤活性。它可介导对人类免疫缺陷病毒(HIV)负调控因子(Nef)的抑制。

象形图

Skull and crossbones
GHS06

警示用语：

Danger

危险分类

Acute Tox. 1 Inhalation - Acute Tox. 2 Dermal - Acute Tox. 2 Oral - Eye Irrit. 2

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

个人防护装备

Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges

法规信息

监管及禁止进口产品

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Stephen F Haydock et al.
Microbiology (Reading, England), 151(Pt 10), 3161-3169 (2005-10-07)
The macrolide antibiotic concanamycin A has been identified as an exceptionally potent inhibitor of the vacuolar (V-type) ATPase. Such compounds have been mooted as the basis of a potential drug treatment for osteoporosis, since the V-ATPase is involved in the
Hideaki Toda et al.
Developmental and comparative immunology, 35(1), 88-93 (2010-09-04)
T cell-mediated cytotoxicity occurs via pathways based on perforin or Fas mechanisms. Perforin is a protein present in the cytoplasmic granules of CD8(+) cytotoxic T lymphocytes and is secreted to form pores on target cell membranes. In fish, although the
Christiane Ott et al.
Redox biology, 10, 266-273 (2016-11-09)
The overall decrease in proteolytic activity in aging can promote and accelerate protein accumulation and metabolic disturbances. To specifically analyze changes in macroautophagy (MA) we quantified different autophagy-related proteins (ATGs) in young, adult and old murine tissue as well as
Mark M Painter et al.
Proceedings of the National Academy of Sciences of the United States of America, 117(38), 23835-23846 (2020-09-10)
Nef is an HIV-encoded accessory protein that enhances pathogenicity by down-regulating major histocompatibility class I (MHC-I) expression to evade killing by cytotoxic T lymphocytes (CTLs). A potent Nef inhibitor that restores MHC-I is needed to promote immune-mediated clearance of HIV-infected
Jörn Dengjel et al.
Molecular & cellular proteomics : MCP, 11(3), M111-M111 (2012-02-09)
Autophagy is one of the major intracellular catabolic pathways, but little is known about the composition of autophagosomes. To study the associated proteins, we isolated autophagosomes from human breast cancer cells using two different biochemical methods and three stimulus types:
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