C9521
Z-Phe-Arg 7-酰氨基-4-甲基香豆素 盐酸盐
kallikrein substrate, ≥95% (HPLC), powder
别名:
Z-Phe-Arg-AMC
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关于此项目
经验公式（希尔记法）:
C33H36N6O6 · HCl
化学文摘社编号:
分子量:
649.14
UNSPSC Code:
12352204
PubChem Substance ID:
NACRES:
NA.32
MDL number:
产品名称
Z-Phe-Arg 7-酰氨基-4-甲基香豆素 盐酸盐, kallikrein substrate
Quality Level
assay
≥95% (HPLC)
form
powder
concentration
≥95%
solubility
methanol: 20 mg/mL, clear, colorless
storage temp.
−20°C
SMILES string
O=C(N[C@@H](CC1=CC=CC=C1)C(N[C@@H](CCCNC(N)=N)C(NC2=CC=C(C(C)=CC(O3)=O)C3=C2)=O)=O)OCC4=CC=CC=C4.[Cl]
InChI
1S/C33H36N6O6/c1-21-17-29(40)45-28-19-24(14-15-25(21)28)37-30(41)26(13-8-16-36-32(34)35)38-31(42)27(18-22-9-4-2-5-10-22)39-33(43)44-20-23-11-6-3-7-12-23/h2-7,9-12,14-15,17,19,26-27H,8,13,16,18,20H2,1H3,(H,37,41)(H,38,42)(H,39,43)(H4,34,35,36)
InChI key
ZZGDDBWFXDMARY-UHFFFAOYSA-N
General description
Z-苯丙氨酸-精氨酸 7-氨基-4-甲基香豆素(Z-FR-AMC）是一种拟肽类底物，可用于木瓜蛋白酶和其它酶，如组织蛋白酶K。它也是组织蛋白酶L和B的荧光合成肽。
一种用于血浆激肽释放酶的荧光底物。
Application
Z-苯丙氨酸-精氨酸7-氨基-4-甲基香豆盐酸盐已被用于：
- 作为猕猴桃碱抑制检测中的荧光底物
- 作为血管舒缓素底物
- 作为荧光检测的胰蛋白酶底物
- 作为组织蛋白酶-L底物
Biochem/physiol Actions
由蛋白酶引发的Z-苯丙氨酸-精氨酸7-氨基-4-甲基香豆素（Z-FR-AMC）的蛋白水解性裂解导致AMC的释放，结果使酶反应中的荧光增强。
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
H Ghoneim et al.
International journal for parasitology, 25(12), 1515-1519 (1995-12-01)
A previously described "major acidic proteinase" of adult Schistosoma mansoni, believed to play a key role in the parasite's metabolism, has been identified as a cathepsin B (Sm31). Purified Sm cathepsin B was not recognized by anti-Sm32 or anti-cathepsin L
C Illy et al.
The Journal of biological chemistry, 272(2), 1197-1202 (1997-01-10)
Within the lysosomal cysteine protease family, cathepsin B is unique due to its ability to act both as an endopeptidase and a peptidyldipeptidase. This latter capacity to remove C-terminal dipeptides has been attributed to the presence of a 20-residue insertion
R M C Deshapriya et al.
Journal of biochemistry, 147(3), 393-404 (2009-11-17)
To identify functionally essential sequences and residues of CTLA-2alpha, in vitro mutagenesis was carried out. The coefficient of inhibition (K(i)) was determined towards rabbit cathepsin L using Z-Phe-Arg-MCA as the substrate. Recombinant CTLA-2alpha inhibited the enzyme potently (K(i) = 15
全球贸易项目编号
| 货号 | GTIN |
|---|---|
| C9521-100MG | 04061832908281 |
| C9521-25MG | 04061833530801 |