所有图片(1)
About This Item
经验公式（希尔记法）:
C30H28N6O6S4
CAS号:
分子量:
696.84
MDL编号:
UNSPSC代码:
12352202
PubChem化学物质编号:
NACRES:
NA.77
质量水平
检测方案
≥95% (HPLC)
形式
powder
储存温度
2-8°C
SMILES字符串
CN1C(=O)C23CC4(C(Nc5ccccc45)N2C(=O)C1(CO)SS3)C67CC89SSC(CO)(N(C)C8=O)C(=O)N9C6Nc%10ccccc7%10
InChI
1S/C30H28N6O6S4/c1-33-21(39)27-11-25(15-7-3-5-9-17(15)31-19(25)35(27)23(41)29(33,13-37)45-43-27)26-12-28-22(40)34(2)30(14-38,46-44-28)24(42)36(28)20(26)32-18-10-6-4-8-16(18)26/h3-10,19-20,31-32,37-38H,11-14H2,1-2H3
InChI key
PZPPOCZWRGNKIR-UHFFFAOYSA-N
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一般描述
毛壳素是一种具有抗菌和细胞抑制活性的真菌代谢物。它属于3,6-附睾硫代二酮哌嗪类，与胶质瘤毒素、孢子虫素、蜘蛛素、米扎氯、黄萎病素A和榅桲杀菌素属同一类。毛壳素是由两个五元环顺式融合而成的分子二聚体。
应用
来自毛壳菌属的毛壳素已用于测定对各种细胞的敏化作用。它还用于策动OS诱导异染色质形成的生物学功能。
生化/生理作用
毛壳素是S-腺苷甲硫氨酸的竞争性抑制剂。毛壳素对SU(VAR)3-9的特异性使该化合物成为研究异染色质介导基因抑制的极好工具。
毛壳素是一种抗菌霉菌毒素。作为赖氨酸特异性组蛋白甲基转移酶的特异性抑制剂，该化合物适合用于研究异染色质介导基因抑制。毛壳素是硫氧还蛋白还原酶-1 (TrxR1)的选择性竞争抑制剂，是其抗癌活性的公认机制。
甲基转移酶，帮助化合物用于异染色质介导的基因抑制研究。
制备说明
溶于DMSO。 在1mg / ml时，溶液在2-8℃下稳定1周。
警示用语：
Warning
危险声明
危险分类
Acute Tox. 4 Oral
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
dust mask type N95 (US), Eyeshields, Gloves
法规信息
监管及禁止进口产品
Romains Joubert et al.
Journal of personalized medicine, 11(1) (2020-12-31)
Facioscapulohumeral dystrophy (FSHD, OMIM: 158900, 158901) is the most common dystrophy in adults and so far, there is no treatment. Different loci of the disease have been characterized and they all lead to the aberrant expression of the DUX4 protein
The molecular structure and absolute configuration of chaetocin
Weber H P
Acta Crystallographica Section B, Structural Crystallography and Crystal Chemistry, 28(10), 2945-2951 (1972)
Dorothea Greiner et al.
Nature chemical biology, 1(3), 143-145 (2006-01-13)
Histone methylation plays a key role in establishing and maintaining stable gene expression patterns during cellular differentiation and embryonic development. Here, we report the characterization of the fungal metabolite chaetocin as the first inhibitor of a lysine-specific histone methyltransferase. Chaetocin
Heterochromatin protects retinal pigment epithelium cells from oxidative damage by silencing p53 target genes
Gong L, et al.
Proceedings of the National Academy of Sciences of the USA, 115(17), E3987-E3995 (2018)
Sophie Bouchat et al.
AIDS (London, England), 26(12), 1473-1482 (2012-05-05)
Reactivation of HIV-1 expression in persistent reservoirs together with an efficient HAART has been proposed as an adjuvant therapy aimed at reaching a functional cure for HIV. Previously, H3K9 methylation was shown to play a major role in chromatin-mediated repression
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