推荐产品
生物来源
mouse
质量水平
偶联物
unconjugated
抗体形式
purified immunoglobulin
抗体产品类型
primary antibodies
克隆
CD8, monoclonal
表单
buffered aqueous solution
种属反应性
guinea pig, human
技术
immunocytochemistry: suitable
immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:200-1:1,000 using ovenight incubation at 4 °C and sections that have been protease-digested or processed by high temperature antigen retrieval
indirect immunofluorescence: 1:500 using overnight incubation at 4 °C
同位素/亚型
IgG1
UniProt登记号
运输
dry ice
储存温度
−20°C
靶向翻译后修饰
unmodified
基因信息
human ... CALCA(796)
rat ... Calca(24241)
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一般描述
降钙素基因相关肽（CGRP）是一种血管舒张剂，属于降钙素肽家族。它由周围和中枢神经紧张系统的运动神经元产生。CGRP有两种形式，α和β，它们具有相似的功能。CGRP的作用是由降钙素受体样受体（CRLR）和受体活性修饰蛋白1（RAMP1）形成的G蛋白偶联受体异二聚体介导的。 CGRP在神经紧张、内分泌、免疫和心血管系统中具有多种生物学作用。 多项研究表明CGRP与偏头痛的病理生理有关，并且正在探索CGRP的拮抗剂作为治疗的选择。
单克隆抗降钙素基因相关肽（CGRP）可识别人和豚鼠CGRP。与大鼠CGRP无交叉反应。
单克隆抗降钙素基因相关肽（CGRP）可识别人和豚鼠CGRP。与大鼠CGRP无交叉反应。
免疫原
对应于大鼠α−降钙素基因相关肽（CGRP）C末端的肽。
应用
抗降钙素基因相关肽（CGRP）抗体适用于使用福尔马林固定、石蜡包埋切片或低温恒温器组织切片以1:200至1:1000的工作抗体稀释度进行免疫组化。该抗体可用于免疫荧光，其工作稀释度为1:500。
外形
含1%BSA和≤0.1%叠氮化钠的PBS溶液
免责声明
除非我们的产品目录或产品附带的其他公司文档另有说明，否则我们的产品仅供研究使用，不得用于任何其他目的，包括但不限于未经授权的商业用途、体外诊断用途、离体或体内治疗用途或任何类型的消费或应用于人类或动物。
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储存分类代码
10 - Combustible liquids
WGK
WGK 1
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
Eyeshields, Faceshields, Gloves, type ABEK (EN14387) respirator filter
法规信息
常规特殊物品
含少量动物源组分生物产品
C Juaneda et al.
Trends in pharmacological sciences, 21(11), 432-438 (2000-12-21)
Calcitonin gene-related peptides (alpha and beta isoforms), better known as CGRPalpha and CGRPbeta, were isolated twenty years ago. In fact, these were the first peptides to be characterized using a molecular cloning strategy, which is not the traditional approach of
Udayasankar Arulmani et al.
European journal of pharmacology, 500(1-3), 315-330 (2004-10-07)
Migraine is a common neurological disorder that is associated with an increase in plasma calcitonin gene-related peptide (CGRP) levels. CGRP, a neuropeptide released from activated trigeminal sensory nerves, dilates intracranial blood vessels and transmits vascular nociception. Therefore, it is propounded
T Esfandyari et al.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 14(10), 1439-1446 (2000-07-06)
The receptor responsible for CGRP-induced ion transport and permeability was examined in tissues from animals treated 7 days previously with trinitrobenzenesulfonic acid to induce colitis or in controls. CGRP caused a concentration-dependent increase in short circuit current (I(sc), EC(50) 21
P-C Fan et al.
Cephalalgia : an international journal of headache, 29(8), 883-890 (2009-02-25)
To investigate the role of plasma calcitonin gene-related peptide (CGRP) in paediatric migraine, we prospectively collected 134 blood samples during or between attacks from 66 migraine, 33 non-migraine headache (non-migraine) and 22 non-headache patients, aged 4-18 years. Plasma CGRP concentrations
Jochen K Lennerz et al.
The Journal of comparative neurology, 507(3), 1277-1299 (2008-01-11)
Calcitonin gene-related peptide (CGRP) is a key mediator in primary headaches including migraine. Animal models of meningeal nociception demonstrate both peripheral and central CGRP effects; however, the target structures remain unclear. To study the distribution of CGRP receptors in the
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