C9396
Z-Gly-Gly-Arg 7-amido-4-methylcoumarin hydrochloride
protease substrate
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关于此项目
经验公式（希尔记法）:
C28H33N7O7 · HCl
化学文摘社编号:
分子量:
616.07
UNSPSC Code:
12352204
PubChem Substance ID:
MDL number:
InChI
1S/C28H33N7O7.ClH/c1-17-12-25(38)42-22-13-19(9-10-20(17)22)34-26(39)21(8-5-11-31-27(29)30)35-24(37)15-32-23(36)14-33-28(40)41-16-18-6-3-2-4-7-18;/h2-4,6-7,9-10,12-13,21H,5,8,11,14-16H2,1H3,(H,32,36)(H,33,40)(H,34,39)(H,35,37)(H4,29,30,31);1H/t21-;/m0./s1
SMILES string
CC(C1=C(O2)C=C(NC([C@H](CCCNC(N)=N)NC(CNC(CNC(OCC3=CC=CC=C3)=O)=O)=O)=O)C=C1)=CC2=O.Cl
InChI key
AYMJBLVMUDFWTM-BOXHHOBZSA-N
assay
≥98% (TLC)
form
powder
solubility
methanol: 50 mg/mL, clear, colorless
storage temp.
−20°C
General description
Fluorogenic substrate for urokinase.
Packaging
Bottomless glass bottle. Contents are inside inserted fused cone.
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
法规信息
新产品
此项目有
M Zimmerman et al.
Proceedings of the National Academy of Sciences of the United States of America, 75(2), 750-753 (1978-02-01)
A direct rate assay for plasminogen activator has been developed using a synthetic fluorogenic peptide substrate, 7-(N-Cbz-glycylglycylargininamido)-4-methylcoumarin trifluoroacetate. The assay correlates well with the standard 125I-labeled fibrin plate assay using highly purified urokinase, culture fluids from WI-38, Chinese hamster vary
Sophie Laine et al.
Molecules (Basel, Switzerland), 26(8) (2021-05-01)
Two DO3A-type ligands conjugated to substrates of urokinase (L3) and caspase-3 (L4) via a propyl-amide linker were synthesized and their lanthanide(III) (Ln3+) complexes studied. A model compound without peptide substrate (L2) and an amine derivative ligand mimicking the state after
Sakthivel Vaiyapuri et al.
PloS one, 5(3), e9687-e9687 (2010-03-20)
Serine proteases are a major component of viper venoms and are thought to disrupt several distinct elements of the blood coagulation system of envenomed victims. A detailed understanding of the functions of these enzymes is important both for acquiring a
Gustavo Lemos Rocha et al.
Plant science : an international journal of experimental plant biology, 288, 110232-110232 (2019-09-16)
Seed coat is the tissue which establishes an interface between the seed inner tissues and external environment. Our group has shown that cowpea seed coat undergoes coordinated events of programmed cell death (PCD) during development. In relation to germinating seed
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