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Merck
CN

C9396

Sigma-Aldrich

Z-Gly-Gly-Arg 7-amido-4-methylcoumarin hydrochloride

protease substrate

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About This Item

经验公式(希尔记法):
C28H33N7O7 · HCl
分子量:
616.07
MDL编号:
UNSPSC代码:
12352204
PubChem化学物质编号:

检测方案

≥98% (TLC)

形式

powder

溶解性

methanol: 50 mg/mL, clear, colorless

储存温度

−20°C

SMILES字符串

CC(C1=C(O2)C=C(NC([C@H](CCCNC(N)=N)NC(CNC(CNC(OCC3=CC=CC=C3)=O)=O)=O)=O)C=C1)=CC2=O.Cl

InChI

1S/C28H33N7O7.ClH/c1-17-12-25(38)42-22-13-19(9-10-20(17)22)34-26(39)21(8-5-11-31-27(29)30)35-24(37)15-32-23(36)14-33-28(40)41-16-18-6-3-2-4-7-18;/h2-4,6-7,9-10,12-13,21H,5,8,11,14-16H2,1H3,(H,32,36)(H,33,40)(H,34,39)(H,35,37)(H4,29,30,31);1H/t21-;/m0./s1

InChI key

AYMJBLVMUDFWTM-BOXHHOBZSA-N

包装

Bottomless glass bottle. Contents are inside inserted fused cone.

底物

Fluorogenic substrate for urokinase.

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

个人防护装备

Eyeshields, Gloves, type N95 (US)

法规信息

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M Zimmerman et al.
Proceedings of the National Academy of Sciences of the United States of America, 75(2), 750-753 (1978-02-01)
A direct rate assay for plasminogen activator has been developed using a synthetic fluorogenic peptide substrate, 7-(N-Cbz-glycylglycylargininamido)-4-methylcoumarin trifluoroacetate. The assay correlates well with the standard 125I-labeled fibrin plate assay using highly purified urokinase, culture fluids from WI-38, Chinese hamster vary
Sakthivel Vaiyapuri et al.
PloS one, 5(3), e9687-e9687 (2010-03-20)
Serine proteases are a major component of viper venoms and are thought to disrupt several distinct elements of the blood coagulation system of envenomed victims. A detailed understanding of the functions of these enzymes is important both for acquiring a
Sophie Laine et al.
Molecules (Basel, Switzerland), 26(8) (2021-05-01)
Two DO3A-type ligands conjugated to substrates of urokinase (L3) and caspase-3 (L4) via a propyl-amide linker were synthesized and their lanthanide(III) (Ln3+) complexes studied. A model compound without peptide substrate (L2) and an amine derivative ligand mimicking the state after
Gustavo Lemos Rocha et al.
Plant science : an international journal of experimental plant biology, 288, 110232-110232 (2019-09-16)
Seed coat is the tissue which establishes an interface between the seed inner tissues and external environment. Our group has shown that cowpea seed coat undergoes coordinated events of programmed cell death (PCD) during development. In relation to germinating seed

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