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Merck
CN

C9394

氯己定 二葡糖酸盐 溶液

20% in H2O

别名:

1,6-双（N5-[对氯苯基]-N1-双胍）己烷；1,1′-六亚甲基双（5-[对氯苯基]双胍）

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关于此项目

化学文摘社编号:
18472-51-0
NACRES:
NA.85
PubChem Substance ID:
329775206
UNSPSC Code:
51102829
MDL number:
MFCD00083599

主要文件

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产品名称

氯己定 二葡糖酸盐 溶液, 20% in H2O

InChI key

YZIYKJHYYHPJIB-UUPCJSQJSA-N

SMILES string

OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C(O)=O.OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C(O)=O.Clc1ccc(NC(=N)NC(=N)NCCCCCCNC(=N)NC(=N)Nc2ccc(Cl)cc2)cc1

InChI

1S/C22H30Cl2N10.2C6H12O7/c23-15-5-9-17(10-6-15)31-21(27)33-19(25)29-13-3-1-2-4-14-30-20(26)34-22(28)32-18-11-7-16(24)8-12-18;2*7-1-2(8)3(9)4(10)5(11)6(12)13/h5-12H,1-4,13-14H2,(H5,25,27,29,31,33)(H5,26,28,30,32,34);2*2-5,7-11H,1H2,(H,12,13)/t;2*2-,3-,4+,5-/m.11/s1

form

liquid

concentration

20% in H2O

solubility

water: soluble 50 % (w/v)

density

1.06 g/mL at 25 °C (lit.)

antibiotic activity spectrum

Gram-negative bacteria
Gram-positive bacteria

mode of action

cell membrane | interferes

storage temp.

2-8°C

Quality Level

200

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相关类别

Application

可用于研究双（双胍）分子破坏膜的作用机制。
氯己定已被用于研究精油与氯己定二葡糖酸盐联合使用时，如何改善皮肤消毒效果 ，并可用于皮肤渗透研究 。 用氯己定慢性冲洗已经证明可以降低NaCl的咸味和奎宁的苦味。

Biochem/physiol Actions

阳离子广谱抗菌剂属于双（双胍）家族。 其作用机制涉及破坏外部细菌膜稳定性。 它主要用作伤口愈合、导管插入部位、各种牙科应用和手术擦洗中的局部抗菌/消毒剂。

Other Notes

保持容器密闭，并置于干燥通风处。打开后的容器必须小心重新密封并保持直立以防止泄漏。光敏感。

pictograms

CorrosionEnvironment
GHS05,GHS09

signalword

Danger

hcodes

H318,H410

Hazard Classifications

Aquatic Acute 1 - Aquatic Chronic 2 - Eye Dam. 1

存储类别

12 - Non Combustible Liquids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Faceshields, Gloves, multi-purpose combination respirator cartridge (US)

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number
0000437087
0000437087
BCCM4197
BCCM4196
BCCL5662

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P A Breslin et al.
Chemical senses, 26(2), 105-116 (2001-03-10)
Chronic rinsing with chlorhexidine, an oral-antiseptic, has been shown to decrease the saltiness of NaCl and the bitterness of quinine. The effect of acute chlorhexidine on taste has not been investigated. The purpose of the present study was to examine
T J Karpanen et al.
Antimicrobial agents and chemotherapy, 52(10), 3633-3636 (2008-08-05)
This study evaluated a model of skin permeation to determine the depth of delivery of chlorhexidine into full-thickness excised human skin following topical application of 2% (wt/vol) aqueous chlorhexidine digluconate. Skin permeation studies were performed on full-thickness human skin using
T J Karpanen et al.
The Journal of antimicrobial chemotherapy, 62(5), 1031-1036 (2008-08-16)
Effective skin antisepsis and disinfection of medical devices are key factors in preventing many healthcare-acquired infections associated with skin microorganisms, particularly Staphylococcus epidermidis. The aim of this study was to investigate the antimicrobial efficacy of chlorhexidine digluconate (CHG), a widely
Chandra C Shenoy et al.
Endocrinology, 158(10), 3605-3619 (2017-09-25)
Progressive scarring is ubiquitous postoperatively and in an array of chronic systemic diseases. Recent studies indicate that such scarring has a high female propensity; females are also almost exclusively affected by endometriosis, a common sex steroid-dependent fibrotic disease. Endometriosis-related fibrosis
Henri Garrison-Desany et al.
Vaccine, 39(2), 423-430 (2020-12-02)
To examine whether anti-tetanus toxoid (anti-TT) immunoglobulin G (IgG) levels measured in oral fluid and adjusted for collection difficulties and specimen quality are associated with total IgG and anti-TTIgG in oral fluid and assess if statistical adjustment for them improves
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Product Information Sheet - C9394

Product Information Sheet

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