C8999
Calpeptin
≥98% (HPLC), calpain inhibitor, powder
别名:
N-苄氧羰基-L-亮氨酰基核, Z-Leu-Nle-CHO
登录 查看组织和合同定价。
选择尺寸
关于此项目
经验公式（希尔记法）:
C20H30N2O4
化学文摘社编号:
分子量:
362.46
UNSPSC Code:
12352200
PubChem Substance ID:
NACRES:
NA.77
MDL number:
产品名称
Calpeptin, ≥98% (HPLC)
SMILES string
CCCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)OCc1ccccc1)C=O
InChI
1S/C20H30N2O4/c1-4-5-11-17(13-23)21-19(24)18(12-15(2)3)22-20(25)26-14-16-9-7-6-8-10-16/h6-10,13,15,17-18H,4-5,11-12,14H2,1-3H3,(H,21,24)(H,22,25)/t17-,18-/m0/s1
InChI key
PGGUOGKHUUUWAF-ROUUACIJSA-N
assay
≥98% (HPLC)
form
powder
color
white to beige
solubility
DMSO: 15 mg/mL, clear
shipped in
wet ice
storage temp.
−20°C
Quality Level
正在寻找类似产品? 访问 产品对比指南
相关类别
General description
Calpeptin (Z-Leu-nLeu-H) 是一种具有细胞渗透性的肽醛抑制剂。与其他抑制剂，如 Z-Leu-Met-H 和 leupeptin 相比，它对钙蛋白酶 I 更敏感。Calpeptin 刺激分化的嗜铬细胞瘤 (PC12) 细胞的神经突延长。Calpeptin 减少实验性自身免疫性脑脊髓炎 (EAE) 脊髓的小胶质细胞增生、星形胶质细胞增生、轴突损伤以及神经元和少突胶质细胞死亡。因此，可以认为它是治疗 EAE 和多发性硬化 (MS) 的强效治疗药物。
Application
Calpeptin 已被用作钙蛋白酶抑制剂。
Biochem/physiol Actions
Calpeptin 是 rho 激酶激活剂和钙蛋白酶抑制剂，钙蛋白酶是钙依赖性半胱氨酸蛋白酶家族，参与细胞凋亡、神经元的长时程增强和细胞周期进程。
Calpeptin 是一种钙蛋白酶抑制剂和 rho 激酶激活剂。
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Heike Hardelauf et al.
Lab on a chip, 11(16), 2763-2771 (2011-06-29)
Spatially defined neuronal networks have great potential to be used in a wide spectrum of neurobiology assays. We present an original technique for the precise and reproducible formation of neuronal networks. A PDMS membrane comprising through-holes aligned with interconnecting microchannels
Calpeptin, a calpain inhibitor, promotes neurite elongation in differentiating PC12 cells.
Pinter M, et al.
Neuroscience Letters, 170(1), 91-93 (1994)
Calpeptin attenuated inflammation, cell death, and axonal damage in animal model of multiple sclerosis.
Guyton M K, et al.
Journal of Neuroscience Research, 88(11), 2398-2408 (2010)
Inhibition of histone deacetylase 3 (HDAC3) mediates ischemic preconditioning and protects cortical neurons against ischemia in rats.
Yang X, et al.
Frontiers in Molecular Neuroscience, 9, 131-131 (2016)
Hector N Aguilar et al.
PloS one, 6(6), e20903-e20903 (2011-06-23)
The 'phosphate-binding tag' (phos-tag) reagent enables separation of phospho-proteins during SDS-PAGE by impeding migration proportional to their phosphorylation stoichiometry. Western blotting can then be used to detect and quantify the bands corresponding to the phospho-states of a target protein. We
我们的科学家团队拥有各种研究领域经验，包括生命科学、材料科学、化学合成、色谱、分析及许多其他领域.
联系客户支持