所有图片(1)
About This Item
经验公式（希尔记法）:
C20H30N2O4
CAS号:
分子量:
362.46
MDL编号:
UNSPSC代码:
12352200
PubChem化学物质编号:
NACRES:
NA.77
推荐产品
质量水平
方案
≥98% (HPLC)
表单
powder
颜色
white to beige
溶解性
DMSO: 15 mg/mL, clear
运输
wet ice
储存温度
−20°C
SMILES字符串
CCCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)OCc1ccccc1)C=O
InChI
1S/C20H30N2O4/c1-4-5-11-17(13-23)21-19(24)18(12-15(2)3)22-20(25)26-14-16-9-7-6-8-10-16/h6-10,13,15,17-18H,4-5,11-12,14H2,1-3H3,(H,21,24)(H,22,25)/t17-,18-/m0/s1
InChI key
PGGUOGKHUUUWAF-ROUUACIJSA-N
一般描述
Calpeptin (Z-Leu-nLeu-H) 是一种具有细胞渗透性的肽醛抑制剂。与其他抑制剂，如 Z-Leu-Met-H 和 leupeptin 相比，它对钙蛋白酶 I 更敏感。Calpeptin 刺激分化的嗜铬细胞瘤 (PC12) 细胞的神经突延长。Calpeptin 减少实验性自身免疫性脑脊髓炎 (EAE) 脊髓的小胶质细胞增生、星形胶质细胞增生、轴突损伤以及神经元和少突胶质细胞死亡。因此，可以认为它是治疗 EAE 和多发性硬化 (MS) 的强效治疗药物。
应用
Calpeptin 已被用作钙蛋白酶抑制剂。
生化/生理作用
Calpeptin 是 rho 激酶激活剂和钙蛋白酶抑制剂，钙蛋白酶是钙依赖性半胱氨酸蛋白酶家族，参与细胞凋亡、神经元的长时程增强和细胞周期进程。
Calpeptin 是一种钙蛋白酶抑制剂和 rho 激酶激活剂。
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
历史批次信息供参考:
分析证书(COA)
Lot/Batch Number
Inhibition of histone deacetylase 3 (HDAC3) mediates ischemic preconditioning and protects cortical neurons against ischemia in rats.
Yang X, et al.
Frontiers in Molecular Neuroscience, 9, 131-131 (2016)
Grace Soong et al.
The Journal of infectious diseases, 205(10), 1571-1579 (2012-03-30)
The USA300 strains of Staphylococcus aureus are the major cause of skin and soft tissue infection in the United States. Invasive USA300 infection has been attributed to several virulence factors, including protein A and the α-hemolysin (Hla), which cause pathology
Hector N Aguilar et al.
PloS one, 6(6), e20903-e20903 (2011-06-23)
The 'phosphate-binding tag' (phos-tag) reagent enables separation of phospho-proteins during SDS-PAGE by impeding migration proportional to their phosphorylation stoichiometry. Western blotting can then be used to detect and quantify the bands corresponding to the phospho-states of a target protein. We
Calpeptin attenuated inflammation, cell death, and axonal damage in animal model of multiple sclerosis.
Guyton M K, et al.
Journal of Neuroscience Research, 88(11), 2398-2408 (2010)
Heike Hardelauf et al.
Lab on a chip, 11(16), 2763-2771 (2011-06-29)
Spatially defined neuronal networks have great potential to be used in a wide spectrum of neurobiology assays. We present an original technique for the precise and reproducible formation of neuronal networks. A PDMS membrane comprising through-holes aligned with interconnecting microchannels
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