推荐产品
产品名称
氯法齐明,
表单
powder
质量水平
抗生素抗菌谱
mycobacteria
作用机制
protein synthesis | interferes
创始人
Novartis
SMILES字符串
CC(C)\N=C1/C=C2N(c3ccc(Cl)cc3)c4ccccc4N=C2C=C1Nc5ccc(Cl)cc5
InChI
1S/C27H22Cl2N4/c1-17(2)30-24-16-27-25(15-23(24)31-20-11-7-18(28)8-12-20)32-22-5-3-4-6-26(22)33(27)21-13-9-19(29)10-14-21/h3-17,31H,1-2H3/b30-24+
InChI key
WDQPAMHFFCXSNU-BGABXYSRSA-N
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一般描述
Clofazimine is a riminophenazine, which is used as an antileprosy drug. It is used to treat multidrug-resistant tuberculosis. Clofazimine prevents neutrophil motility and lymphocyte transformation. It has anti-inflammatory effect, which is used to treat discoid lupus erythematosus. Clofazimine has immunosuppressive property.
应用
Clofazimine has been used:
- for antimicrobial preparation
- to study its accumulation on macrophages to form crystal-like drug inclusions (CLDIs)
- to model drug-induced hepatic granulomatous inflammation
- to study the in vivo cargo storage capacity of macrophages
特点和优势
This compound was developed by Novartis. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.
储存及稳定性
This product is stored at room temperature.
储存分类代码
11 - Combustible Solids
WGK
WGK 3
个人防护装备
dust mask type N95 (US), Eyeshields, Gloves
法规信息
监管及禁止进口产品
从最新的版本中选择一种：
分析证书(COA)
Lot/Batch Number
Sarah Schmidt Grant et al.
Proceedings of the National Academy of Sciences of the United States of America, 109(30), 12147-12152 (2012-07-11)
During Mycobacterium tuberculosis infection, a population of bacteria likely becomes refractory to antibiotic killing in the absence of genotypic resistance, making treatment challenging. We describe an in vitro model capable of yielding a phenotypically antibiotic-tolerant subpopulation of cells, often called
Macrophage-mediated clofazimine sequestration is accompanied by a shift in host energy metabolism
Trexel J, et al.
Journal of Pharmaceutical Sciences, 106(4), 1162-1174 (2017)
Mode of action of clofazimine and combination therapy with benzothiazinones against Mycobacterium tuberculosis
Lechartier B and Cole ST
Antimicrobial Agents and Chemotherapy, 59(8), 4457-4463 (2015)
The Antimicrobial Drugs (2000)
An Expandable Mechanopharmaceutical Device (2): Drug Induced Granulomas Maximize the Cargo Sequestering Capacity of Macrophages in the Liver
Rzeczycki P, et al.
Pharmaceutical Research, 36(1), 3-3 (2019)
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