C8874
CGP-37157
≥98% (HPLC), SERCA antagonist , powder
别名:
7-氯-5-（2-氯苯基）-1,5-二氢-4,1-苯并噻唑-2-2（3H）-酮
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关于此项目
经验公式（希尔记法）:
C15H11Cl2NOS
化学文摘社编号:
分子量:
324.22
MDL编号:
UNSPSC代码:
12352200
PubChem化学物质编号:
NACRES:
NA.25
一般描述
CGP-37157 是苯并噻氮平化合物，衍生自氯硝西泮。它可作为肌浆网/内质网 Ca2+ ATPase（SERCA）拮抗剂和兰尼碱受体通道（RyR）激动剂。CGP-37157 调节平滑肌、心脏和骨骼肌细胞以及非肌肉系统中钙的胞内信号传导。
应用
CGP-37157 作为线粒体钠钙交换剂（mNCX）抑制剂，用于研究正常线粒体钙动力学在维持树突棘生成中的作用。
生化/生理作用
线粒体 Na+/Ca2+ 交换以及肌质网钙刺激的 ATPase 和其他钙通道的特异性抑制剂。
储存分类代码
11 - Combustible Solids
WGK
WGK 3
Michael Patterson et al.
The Journal of general physiology, 129(1), 29-56 (2006-12-28)
Many models have been developed to account for stimulus-evoked [Ca(2+)] responses, but few address how responses elicited in specific cell types are defined by the Ca(2+) transport and buffering systems that operate in the same cells. In this study, we
Cyclophilin D regulates neuronal activity-induced filopodiagenesis by fine-tuning dendritic mitochondrial calcium dynamics
Sui S, et al.
Journal of Neurochemistry (2018)
CGP-37157 inhibits the sarcoplasmic reticulum Ca2+ ATPase and activates ryanodine receptor channels in striated muscle
Neumann JT, et al.
Molecular Pharmacology, 79(1), 141-147 (2011)
Cheng Wei Lu et al.
Neurochemistry international, 140, 104845-104845 (2020-09-11)
Indole-3-carbinol (I3C), found in cruciferous vegetables, has been proposed to exhibit neuroprotective effects. This study aimed to investigate the effect of the I3C derivative [1(4-chloro-3-nitrobenzenesulfonyl)-1H-indol-3-yl]-methanol (CIM), which has superior pharmacokinetic properties to I3C, on glutamate release in rat cerebrocortical nerve
S L Colegrove et al.
The Journal of general physiology, 115(3), 351-370 (2000-02-29)
We studied how mitochondrial Ca2+ transport influences [Ca2+](i) dynamics in sympathetic neurons. Cells were treated with thapsigargin to inhibit Ca2+ accumulation by SERCA pumps and depolarized to elevate [Ca2+(i); the recovery that followed repolarization was then examined. The total Ca2+
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