跳转至内容
Merck
CN
所有图片(1)

文件

安全信息

C8742

Sigma-Aldrich

CHIC-35

≥97% (chiral, HPLC)

别名:

(6S)-2-Chloro-5,6,7,8,9,10-hexahydro-cyclohept[b]indole-6-carboxamide, Compound (S)-35

登录查看公司和协议定价
所有图片(1)

About This Item

经验公式（希尔记法）:
C14H15ClN2O
CAS号:
848193-72-6
分子量:
262.73
MDL编号:
MFCD11045286
UNSPSC代码:
12352200
PubChem化学物质编号:
329775186
NACRES:
NA.77

质量水平

100

检测方案

≥97% (chiral, HPLC)

形式

solid

溶解性

DMSO: >10 mg/mL
H2O: <2 mg/mL

储存温度

2-8°C

SMILES字符串

ClC1=CC=C(NC2=C3CCCC[C@@H]2C(N)=O)C3=C1

InChI

1S/C14H15ClN2O/c15-8-5-6-12-11(7-8)9-3-1-2-4-10(14(16)18)13(9)17-12/h5-7,10,17H,1-4H2,(H2,16,18)/t10-/m0/s1

InChI key

ABIVOOWWGYJNLV-JTQLQIEISA-N

生化/生理作用

CHIC-35 is cell-permeable, metabolically stable, and very potent inhibitor of SIRT1; IC50 of S-isomer is 60 nM; IC50 of mixed isomers is 124 nM. There is no inhibition of SIRT3 or HDAC. The IC50 for SIRT2 is 2.77 μM. Sirtuins are protein deacetylases, which represent a new class of histone deacetylases (HDAC) involved in gene silencing. SIRT modulators are potential therapeutics for cancer, diabetes, muscle differentiation, heart failure, neurodegeneration, and aging.

特点和优势

This compound is a featured product for Gene Regulation research. Click here to discover more featured Gene Regulation products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

WGK

WGK 3

个人防护装备

dust mask type N95 (US), Eyeshields, Faceshields, Gloves

法规信息

新产品

分析证书(COA)

输入产品批号来搜索 分析证书(COA) 。批号可以在产品标签上"批“ （Lot或Batch）字后找到。

已有该产品？

在文件库中查找您最近购买产品的文档。

访问文档库

商品

Discover Bioactive Small Molecules for Gene Regulation

We offer a variety of small molecule research tools, such as transcription factor modulators, inhibitors of chromatin modifying enzymes, and agonists/antagonists for target identification and validation in gene regulation research; a selection of these research tools is shown below.

我们的科学家团队拥有各种研究领域经验，包括生命科学、材料科学、化学合成、色谱、分析及许多其他领域.

联系技术服务部门