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表单
lyophilized powder
质量水平
比活
≥250 units/mg protein (E1%/280)
分子量
~45 kDa
颜色
white
UniProt登记号
储存温度
−20°C
基因信息
human ... CTSD(1509)
1 of 4
此商品 | D8375 | D6134 | M9376 |
|---|---|---|---|
| biological source synthetic (organic) | biological source synthetic | biological source synthetic (organic) | biological source synthetic (organic) |
| assay ≥98% (GC) | assay ≥98% (GC) | assay ≥99% (GC) | assay ≥99% (GC) |
| Quality Level 200 | Quality Level 200 | Quality Level 200 | Quality Level 200 |
| solubility H2O: 1 M at 20 °C, clear, colorless | solubility H2O: 0.250 g/5mL | solubility H2O: soluble 330 mg/mL, clear, colorless | solubility water: 50 mg/mL, clear, colorless |
| form powder | form crystalline | form crystalline | form powder |
一般描述
组织蛋白酶D是一种天冬氨酸蛋白酶，位于溶酶体中。它可参与蛋白质分解代谢并维持激素和抗原的加工过程。组织蛋白酶D与肿瘤形成和神经退行性改变有关。它可调节溶酶体蛋白水解和内源性纤维蛋白溶解。[1]
生化/生理作用
内体溶酶体天冬氨酸蛋白酶与乳腺癌转移和阿尔茨海默病有关。在细胞凋亡的人包皮成纤维细胞中，发现组织蛋白酶D的溶酶体释放先于细胞色素c的释放和膜电位的丧失。
组织蛋白酶D是一种内体-溶酶体天冬氨酸蛋白酶，与乳腺癌转移和阿尔茨海默病有关。在细胞凋亡的人包皮成纤维细胞中，发现组织蛋白酶D的溶酶体释放先于细胞色素c的释放和膜电位的丧失。诱导凋亡后12至24小时，PC12细胞中的组织蛋白酶D水平升高。
其他说明
等电聚焦观察到含有α、β和γ同工酶。
单位定义
在pH3.3，37°C条件下，一单位可在30分钟内导致A280 增加1.0个单位，该活性利用酸变性血红蛋白作为底物，通过TCA可溶产物进行测定（1 cm光路）。
外形
含磷酸钠缓冲盐的粉末。
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
法规信息
常规特殊物品
历史批次信息供参考:
分析证书(COA)
Lot/Batch Number
Mengjie Ma et al.
Molecules (Basel, Switzerland), 28(13) (2023-07-14)
In this study, cathepsin D was oxidized in vitro with different concentrations of H2O2, and the activity, structure, and extent of myofibrillar protein degradation by oxidized cathepsin D were evaluated. The sulfhydryl content of cathepsin D decreased to 9.20% after
Aspartic Proteinases Physiology and Pathology (1995)
Jeane do Nascimento Moraes et al.
The journal of venomous animals and toxins including tropical diseases, 28, e20220002-e20220002 (2022-11-22)
Cathepsin D (CatD) is a lysosomal proteolytic enzyme expressed in almost all tissues and organs. This protease is a multifunctional enzyme responsible for essential biological processes such as cell cycle regulation, differentiation, migration, tissue remodeling, neuronal growth, ovulation, and apoptosis.
Platelet membrane beta-secretase activity in mild cognitive impairment and conversion to dementia: a longitudinal study
McGuinness B, et al.
Journal of Alzheimer'S Disease, 49(4), 1095-1103 (2016)
Andrea Gilg et al.
Journal of translational medicine, 19(1), 190-190 (2021-05-05)
Endogenous Peptide Inhibitor of CXCR4 (EPI-X4) is a natural antagonist of the CXC chemokine receptor 4 (CXCR4). EPI-X4 is a 16-mer peptide that is released from human serum albumin (HSA) by acidic aspartic proteases such as Cathepsin D and E.
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