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质量水平
方案
≥97% (HPLC)
表单
powder
颜色
white to beige
溶解性
DMSO: 10 mg/mL, clear
储存温度
2-8°C
SMILES字符串
CC1(C)C([C@@H](O)C[C@]2([H])C1=CC[C@]([C@@](C[C@@H](O)[C@]3([H])[C@@](C)(O)C(/C=C/C(C)(C)OC(C)=O)=O)(C)[C@]3(C)C4)([H])[C@@]2(C)C4=O)=O
InChI
1S/C32H46O8/c1-17(33)40-27(2,3)13-12-23(36)32(9,39)25-21(35)15-29(6)22-11-10-18-19(14-20(34)26(38)28(18,4)5)31(22,8)24(37)16-30(25,29)7/h10,12-13,19-22,25,34-35,39H,11,14-16H2,1-9H3/b13-12+/t19-,20+,21-,22+,25+,29+,30-,31+,32+/m1/s1
InChI key
IXQKXEUSCPEQRD-DKRGWESNSA-N
应用
葫芦素B水合物已被用于：
- 作为转录活化因子3 (stat3) 抑制剂的信号转导分子和激活剂，用于测定其对人溶酶体酸脂肪酶（hLAL）在骨髓来源的抑制性细胞 (MDSC) 中表达的影响。
- 作为脱皮素受体 (EcR) 拮抗剂注射液，用于降低蝴蝶中29-羟基脱皮素 (20E) 的信号传导水平
- 用于确定其对胰腺癌细胞系细胞活力的作用。
生化/生理作用
葫芦素B是STAT3途径的一种抑制剂。
葫芦素B是葫芦科植物物种的一种三萜类成分。葫芦素B可通过诱导细胞凋亡和在G2/M期诱导细胞周期停滞，从而抑制多种肿瘤细胞系（IC50 15-30nM）的增殖。尽管其作用机制尚不清楚，但葫芦素B可抑制STAT3的磷酸化和表达水平，并已显示出阻断JAK2的活性。葫芦素B也可抑制HIF1a和Nf-KB的转录活性。葫芦素B在结构上与JAK抑制剂Curcubitacin I类似。
葫芦素B通过抑制乳腺癌中的端粒酶和c-Myc而显示抗癌活性。它还具有很高的抗动脉粥样硬化活性。葫芦素B也具有消炎和抗微生物活性。
特点和优势
这种化合物是激酶磷酸酶生物学研究的特色产品。点击此处发现更多特色激酶磷酸酶生物产品。在sigma.com/discover-bsm可了解更多关于生物活性小分子的其他研究领域。
警示用语：
Danger
危险声明
危险分类
Acute Tox. 2 Oral
储存分类代码
6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
历史批次信息供参考:
分析证书(COA)
Lot/Batch Number
Meixia Zhang et al.
Pancreas, 39(6), 923-929 (2010-02-26)
Pancreatic cancer is a serious disease worldwide for its high mortality. Gemcitabine has become the frontline option for the treatment of this disease since its approval. However, resistance to the drug has been on the rise in recent years. Searching
Cytotoxic Effect of Bitter Melon (Momordica charantia L.) Ethanol Extract and Its Fractions on Pancreatic Cancer Cells in vitro
Richmond, et al.
Exploratory research and hypothesis in medicine, 2, 139-139 (2017)
Moltira Promkan et al.
PloS one, 8(2), e55732-e55732 (2013-02-09)
Cucurbitacin B (CuB) is one of the potential agents for long term anticancer chemoprevention. Cumulative evidences has shown that cucurbitacin B provides potent cellular biological activities such as hepatoprotective, anti-inflammatory and antimicrobial effects, but the precise mechanism of this agent
Wenyu Wang et al.
Drug delivery, 17(3), 114-122 (2010-02-13)
This study intended to prepare liver-targeting solid lipid nanoparticles (SLNs) with a hepatoprotective drug, cucurbitacin B (Cuc B), using a galactosylated lipid, N-hexadecyl lactobionamide (N-HLBA). The galactosyl-lipid N-HLBA was prepared via the lactone form intermediates of lactobionic acid and synthesized
Sumana Dakeng et al.
Journal of cellular biochemistry, 113(1), 49-60 (2011-08-26)
The cucurbitacins are tetracyclic triterpenes found in plants of the family Cucurbitaceae. Cucurbitacins have been shown to have anti-cancer and anti-inflamatory activities. We investigated the anti-cancer activity of cucurbitacin B extracted from Thai medicinal plant Trichosanthes cucumerina Linn. Cell viability
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